The zymogen of plasmepsin v from Plasmodium falciparum is enzymatically active

Molecular and Biochemical Parasitology

Volumn 197, Issue 1-2, 2014, Pages 56-63

  Xiao, Huogen ^a   Bryksa, Brian C ^a   Bhaumik, Prasenjit ^b   Gustchina, Alla ^c   Kiso, Yoshiaki ^d   Yao, Shao Q ^e   Wlodawer, Alexander ^c   Yada, Rickey Y ^a,f  

^a UNIVERSITY OF GUELPH   (Canada)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Plasmepsin; Plasmodium falciparum; Prosegment; Protease inhibitor; Refolding; Zymogen

Indexed keywords

ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; ENZYME PRECURSOR; HYBRID PROTEIN; PLASMEPSIN V; THIOREDOXIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PLASMEPSIN; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; NONHUMAN; PH; PLASMODIUM FALCIPARUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN REFOLDING; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM;

PLASMODIUM FALCIPARUM;

ASPARTIC ACID ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME PRECURSORS; PLASMODIUM FALCIPARUM; PROTEIN REFOLDING; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84911873011     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2014.10.004     Document Type: Article

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