Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes

Biochemical Journal

Volumn 373, Issue 1, 2003, Pages 231-239

  Basak, Ajoy ^a   Lazure, Claude ^b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Enzyme inhibitor; Prodomain peptide; Subtilase

Indexed keywords

AMINO ACIDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HYDROPHILICITY;

PROPROTEIN CONVERTASES (PC);

ENZYMES;

ENZYME INHIBITOR; FURIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 3; PROTEIN PRECURSOR; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ARTICLE; COMPETITIVE INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROPHILICITY; IN VITRO STUDY; KINETICS; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ALIGNMENT; SOLID;

AMINO ACID SEQUENCE; AUTOMATION; CARBOXYPEPTIDASE H; CARBOXYPEPTIDASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FURIN; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROPROTEIN CONVERTASE 5; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; SERINE ENDOPEPTIDASES; SUBTILISINS;

EID: 0037668063     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030120     Document Type: Article

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