Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Pepin, Emilie ^a   Higa, Arisa ^b   Schuster Klein, Carole ^d   Bernard, Catherine ^d   Sulpice, Thierry ^a,c   Guardiola, Beatrice ^d   Chevet, Eric ^b   Alquier, Thierry ^e  

^a Betagenex Inc   (Canada)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c Physiogenex SAS   (France)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE; CYTOKINE; GLUCOSE; INSULIN; LIPOPOLYSACCHARIDE; PALMITIC ACID; SHORT HAIRPIN RNA; MAP3K5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CYTOKINE RESPONSE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENDOTOXEMIA; ENZYME ACTIVATION; GENE DELETION; GENE SILENCING; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INFLAMMATION; INSULIN RELEASE; INSULIN SENSITIVITY; LIPOTOXICITY; MALE; MIN6 CELL LINE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET DISEASE; WILD TYPE; ANIMAL; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; PHYSIOLOGICAL STRESS; SECRETION (PROCESS);

ANIMALS; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; INFLAMMATION; INSULIN; INSULIN-SECRETING CELLS; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASE 5; MICE; MICE, KNOCKOUT; PALMITIC ACID; STRESS, PHYSIOLOGICAL;

EID: 84911385616     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112714     Document Type: Article

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