Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17190-17201

  Taouji, Saïd ^a,b   Higa, Arisa ^a,b   Delom, Frédéric ^c   Palcy, Sandrine ^c   Mahon, François Xavier ^a,c   Pasquet, Jean Max ^a,c   Bossé, Roger ^d   Ségui, Bruno ^e   Chevet, Eric ^a,b,c  

^a Laboratoire de Bactériologie   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c MCGILL UNIVERSITY   (Canada)

^d INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^e CANCER RESEARCH CENTER OF TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURVIVAL; ENDOPLASMIC RETICULUM; HUMAN PROTEINS; SERINE PALMITOYLTRANSFERASES; SPHINGOLIPID METABOLISM; SPHINGOLIPIDS; THERAPEUTIC STRATEGY; TYROSINE KINASE;

BIOCHEMISTRY; BIOSYNTHESIS; CELL DEATH; CELL MEMBRANES; ENZYMES; PHOSPHORYLATION;

AMINO ACIDS;

BCR ABL PROTEIN; CERAMIDE; IMATINIB; SERINE PALMITOYLTRANSFERASE; SERINE PALMITOYLTRANSFERASE LONG CHAIN 1; SHORT HAIRPIN RNA; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; COMPUTER MODEL; CONTROLLED STUDY; DRUG SENSITIVITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GOLGI COMPLEX; IN VITRO STUDY; MICROSOME; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEOMICS;

APOPTOSIS; ENDOPLASMIC RETICULUM (ER); IMATINIB; PROTEIN KINASES; PROTEIN PHOSPHORYLATION; SPHINGOLIPID; SPTLC1;

AMINO ACID SUBSTITUTION; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZAMIDES; CELL NUCLEUS; CELL SURVIVAL; CERAMIDES; DOGS; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; FUSION PROTEINS, BCR-ABL; GENE KNOCKDOWN TECHNIQUES; GOLGI APPARATUS; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICROSOMES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PHOSPHOTYROSINE; PIPERAZINES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTEOME; PYRIMIDINES; RNA, SMALL INTERFERING; SERINE C-PALMITOYLTRANSFERASE; TRANSCRIPTION, GENETIC;

EID: 84879042650     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.409185     Document Type: Article

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