-
1
-
-
0034523818
-
Pro-Apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
-
Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Pro-Apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 2000; 7: 1166-1173.
-
(2000)
Cell Death Differ
, vol.7
, pp. 1166-1173
-
-
Korsmeyer, S.J.1
Wei, M.C.2
Saito, M.3
Weiler, S.4
Oh, K.J.5
Schlesinger, P.H.6
-
2
-
-
0035876483
-
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
-
Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 2001; 15: 1481-1486.
-
(2001)
Genes Dev
, vol.15
, pp. 1481-1486
-
-
Zong, W.X.1
Lindsten, T.2
Ross, A.J.3
MacGregor, G.R.4
Thompson, C.B.5
-
3
-
-
0033596980
-
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
Zou H, Li Y, Liu X, Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999; 274: 11549-11556.
-
(1999)
J Biol Chem
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
-
4
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
-
5
-
-
0033790715
-
TRAIL receptor-2 signals apoptosis through FADD and caspase-8
-
Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell biol 2000; 2: 241-243.
-
(2000)
Nat Cell biol
, vol.2
, pp. 241-243
-
-
Bodmer, J.L.1
Holler, N.2
Reynard, S.3
Vinciguerra, P.4
Schneider, P.5
Juo, P.6
-
6
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi A, Dixit VM. Death receptors: Signaling and modulation. Science 1998; 281 1308.
-
(1998)
Science
, vol.281
, pp. 1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
7
-
-
0032505127
-
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
-
Juo P, Kuo CJ, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol 1998; 8: 1001-1008.
-
(1998)
Curr Biol
, vol.8
, pp. 1001-1008
-
-
Juo, P.1
Kuo, C.J.2
Yuan, J.3
Blenis, J.4
-
8
-
-
34548031870
-
The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
-
Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W et al. The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 2007; 14: 1590-1604.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1590-1604
-
-
Fernandes-Alnemri, T.1
Wu, J.2
Yu, J.W.3
Datta, P.4
Miller, B.5
Jankowski, W.6
-
9
-
-
84878245034
-
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
-
Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N et al. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol 2013; 14: 543-553.
-
(2013)
Nat Immunol
, vol.14
, pp. 543-553
-
-
Sokolovska, A.1
Becker, C.E.2
Ip, W.K.3
Rathinam, V.A.4
Brudner, M.5
Paquette, N.6
-
10
-
-
84857404572
-
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
-
Vince JE, Wong WW, Gentle I, Lawlor KE, Allam R, O'Reilly L et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 2012; 36: 215-227.
-
(2012)
Immunity
, vol.36
, pp. 215-227
-
-
Vince, J.E.1
Wong, W.W.2
Gentle, I.3
Lawlor, K.E.4
Allam, R.5
O'Reilly, L.6
-
11
-
-
0041666539
-
Q-VD-OPh a broad spectrum caspase inhibitor with potent antiapoptotic properties
-
Caserta TM, Smith AN, Gultice AD, Reedy MA, Brown TL. Q-VD-OPh a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 2003; 8: 345-352.
-
(2003)
Apoptosis
, vol.8
, pp. 345-352
-
-
Caserta, T.M.1
Smith, A.N.2
Gultice, A.D.3
Reedy, M.A.4
Brown, T.L.5
-
12
-
-
33644840693
-
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
-
Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112-119.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 112-119
-
-
Degterev, A.1
Huang, Z.2
Boyce, M.3
Li, Y.4
Jagtap, P.5
Mizushima, N.6
-
13
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008; 4: 313-321.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'en, I.L.4
Korkina, O.5
Teng, X.6
-
14
-
-
84862907788
-
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
-
Sun L, Wang H, Wang Z, He S, Chen S, Liao D et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012; 148: 213-227.
-
(2012)
Cell
, vol.148
, pp. 213-227
-
-
Sun, L.1
Wang, H.2
Wang, Z.3
He, S.4
Chen, S.5
Liao, D.6
-
15
-
-
84862909353
-
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
-
Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012; 148 243.
-
(2012)
Cell
, vol.148
, pp. 243
-
-
Wang, Z.1
Jiang, H.2
Chen, S.3
Du, F.4
Wang, X.5
-
16
-
-
84878964122
-
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
-
Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE et al. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis 2013; 4: E465.
-
(2013)
Cell Death Dis
, vol.4
-
-
Moujalled, D.M.1
Cook, W.D.2
Okamoto, T.3
Murphy, J.4
Lawlor, K.E.5
Vince, J.E.6
-
17
-
-
0030298294
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
-
Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996; 87: 565-576.
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
Karin, M.4
-
18
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
19
-
-
1342285692
-
Tumor necrosis factor: An apoptosis JuNKie?
-
Varfolomeev EE, Ashkenazi A. Tumor necrosis factor: An apoptosis JuNKie? Cell 2004 491-497.
-
(2004)
Cell
, pp. 491-497
-
-
Varfolomeev, E.E.1
Ashkenazi, A.2
-
20
-
-
84896789534
-
RIPK1 and RIPK3-induced cell death mode is determined by substrate availability
-
(in revision
-
Cook WD, Moujalled DM, Ralph T, Lock P, Young SN, Murphy JM et al. RIPK1 and RIPK3-induced cell death mode is determined by substrate availability. Cell Death Diff (in revision).
-
Cell Death Diff
-
-
Cook, W.D.1
Moujalled, D.M.2
Ralph, T.3
Lock, P.4
Young, S.N.5
Murphy, J.M.6
-
21
-
-
0029807304
-
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
-
Farrar MA, Alberol-Ila J, Perlmutter RM. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature 1996; 383: 178-181.
-
(1996)
Nature
, vol.383
, pp. 178-181
-
-
Farrar, M.A.1
Alberol-Ila, J.2
Perlmutter, R.M.3
-
22
-
-
70349944660
-
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
-
Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW et al. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol 2009; 186: 805-816.
-
(2009)
J Cell Biol
, vol.186
, pp. 805-816
-
-
Wakabayashi, J.1
Zhang, Z.2
Wakabayashi, N.3
Tamura, Y.4
Fukaya, M.5
Kensler, T.W.6
-
23
-
-
68249087424
-
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
-
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K et al. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 2009; 11: 958-966.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 958-966
-
-
Ishihara, N.1
Nomura, M.2
Jofuku, A.3
Kato, H.4
Suzuki, S.O.5
Masuda, K.6
-
24
-
-
84884308522
-
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
-
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013; 39: 443-453.
-
(2013)
Immunity
, vol.39
, pp. 443-453
-
-
Murphy, J.M.1
Czabotar, P.E.2
Hildebrand, J.M.3
Lucet, I.S.4
Zhang, J.G.5
Alvarez-Diaz, S.6
-
26
-
-
0035487808
-
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
-
Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001; 1: 515-525.
-
(2001)
Dev Cell
, vol.1
, pp. 515-525
-
-
Frank, S.1
Gaume, B.2
Bergmann-Leitner, E.S.3
Leitner, W.W.4
Robert, E.G.5
Catez, F.6
-
27
-
-
33749623421
-
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis
-
Parone PA, James DI, Da Cruz S, Mattenberger Y, Donze O, Barja F et al. Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol 2006; 26: 7397-7408.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7397-7408
-
-
Parone, P.A.1
James, D.I.2
Da Cruz, S.3
Mattenberger, Y.4
Donze, O.5
Barja, F.6
-
28
-
-
35148832011
-
Drp1 mediates caspaseindependent type III cell death in normal and leukemic cells
-
Bras M, Yuste VJ, Roue G, Barbier S, Sancho P, Virely C et al. Drp1 mediates caspaseindependent type III cell death in normal and leukemic cells. Mol Cell Biol 2007; 27 7088.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7088
-
-
Bras, M.1
Yuste, V.J.2
Roue, G.3
Barbier, S.4
Sancho, P.5
Virely, C.6
-
29
-
-
34249019899
-
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis
-
Estaquier J, Arnoult D. Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis. Cell Death Diff 2007; 14 1094.
-
(2007)
Cell Death Diff
, vol.14
, pp. 1094
-
-
Estaquier, J.1
Arnoult, D.2
-
30
-
-
28444487509
-
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death
-
Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J et al. Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol 2005; 15: 2112-2118.
-
(2005)
Curr Biol
, vol.15
, pp. 2112-2118
-
-
Arnoult, D.1
Rismanchi, N.2
Grodet, A.3
Roberts, R.G.4
Seeburg, D.P.5
Estaquier, J.6
-
31
-
-
38849099158
-
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
-
Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 2008; 14: 193-204.
-
(2008)
Dev Cell
, vol.14
, pp. 193-204
-
-
Cassidy-Stone, A.1
Chipuk, J.E.2
Ingerman, E.3
Song, C.4
Yoo, C.5
Kuwana, T.6
-
32
-
-
39549092425
-
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis
-
Tanaka A, Youle RJ. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell 2008; 29: 409-410.
-
(2008)
Mol Cell
, vol.29
, pp. 409-410
-
-
Tanaka, A.1
Youle, R.J.2
-
33
-
-
66349112329
-
Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: The key role of the F-Actin cytoskeleton
-
Barbier S, Chatre L, Bras M, Sancho P, Roue G, Virely C et al. Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: The key role of the F-Actin cytoskeleton. Haematologica 2009; 94: 507-517.
-
(2009)
Haematologica
, vol.94
, pp. 507-517
-
-
Barbier, S.1
Chatre, L.2
Bras, M.3
Sancho, P.4
Roue, G.5
Virely, C.6
-
34
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
Feltham, R.4
Chau, D.5
Ahmed, A.U.6
-
35
-
-
37349131080
-
Cytoplasmic p53 is not required for PUMA-induced apoptosis
-
Callus BA, Ekert PG, Heraud JE, Jabbour AM, Kotevski A, Vince JE et al. Cytoplasmic p53 is not required for PUMA-induced apoptosis. Cell Death Diff 2008; 15 215.
-
(2008)
Cell Death Diff
, vol.15
, pp. 215
-
-
Callus, B.A.1
Ekert, P.G.2
Heraud, J.E.3
Jabbour, A.M.4
Kotevski, A.5
Vince, J.E.6
|