메뉴 건너뛰기




Volumn 15, Issue 11, 2014, Pages 1128-1138

Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human

Author keywords

Hematopoiesis; Human pluripotent stem cells; Leukemia; Notch

Indexed keywords

ALPHA SECRETASE INHIBITOR; ANTILEUKEMIC AGENT; BORTEZOMIB; GAMMA SECRETASE INHIBITOR; GLUCOCORTICOID; JAGGED1; NOTCH RECEPTOR; NOTCH RECEPTOR ANTIBODY; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; UNCLASSIFIED DRUG;

EID: 84910153374     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201438842     Document Type: Review
Times cited : (32)

References (104)
  • 1
    • 84910123300 scopus 로고
    • Mechanism of the origin of x-ray induced notch deficiencies in Drosophila melanogaster
    • Demerec M, Fano U (1941) Mechanism of the origin of x-ray induced notch deficiencies in Drosophila melanogaster. Proc Natl Acad Sci USA 27: 24-31
    • (1941) Proc Natl Acad Sci USA , vol.27 , pp. 24-31
    • Demerec, M.1    Fano, U.2
  • 2
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-661
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3    Soreng, A.L.4    Reynolds, T.C.5    Smith, S.D.6    Sklar, J.7
  • 4
    • 24944501849 scopus 로고    scopus 로고
    • The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
    • Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, Boulter J, Sun YE, Kintner C, Weinmaster (2005) The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol 170: 983-992
    • (2005) J Cell Biol , vol.170 , pp. 983-992
    • Ladi, E.1    Nichols, J.T.2    Ge, W.3    Miyamoto, A.4    Yao, C.5    Yang, L.T.6    Boulter, J.7    Sun, Y.E.8    Kintner, C.9    Weinmaster10
  • 5
    • 0034021393 scopus 로고    scopus 로고
    • Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis
    • Singh N, Phillips RA, Iscove NN, Egan SE (2000) Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis. Exp Hematol 28: 527-534
    • (2000) Exp Hematol , vol.28 , pp. 527-534
    • Singh, N.1    Phillips, R.A.2    Iscove, N.N.3    Egan, S.E.4
  • 7
    • 84859608557 scopus 로고    scopus 로고
    • Hematopoietic stem cells: To be or Notch to be
    • Bigas A, Espinosa L (2012) Hematopoietic stem cells: to be or Notch to be. Blood 119: 3226-3235
    • (2012) Blood , vol.119 , pp. 3226-3235
    • Bigas, A.1    Espinosa, L.2
  • 8
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284: 770-776
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 10
    • 0036778127 scopus 로고    scopus 로고
    • CSL-independent Notch signalling: A checkpoint in cell fate decisions during development?
    • Martinez Arias A, Zecchini V, Brennan K (2002) CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? Curr Opin Genet Dev 12: 524-533
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 524-533
    • Martinez Arias, A.1    Zecchini, V.2    Brennan, K.3
  • 12
    • 84865241459 scopus 로고    scopus 로고
    • The Notch signalling system: Recent insights into the complexity of a conserved pathway
    • Guruharsha KG, Kankel MW, Artavanis-Tsakonas S (2012) The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet 13: 654-666
    • (2012) Nat Rev Genet , vol.13 , pp. 654-666
    • Guruharsha, K.G.1    Kankel, M.W.2    Artavanis-Tsakonas, S.3
  • 20
    • 78650335900 scopus 로고    scopus 로고
    • Deletion-based mechanisms of Notch1 activation in T-ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1
    • Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC (2010) Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 116: 5455-5464
    • (2010) Blood , vol.116 , pp. 5455-5464
    • Ashworth, T.D.1    Pear, W.S.2    Chiang, M.Y.3    Blacklow, S.C.4    Mastio, J.5    Xu, L.6    Kelliher, M.7    Kastner, P.8    Chan, S.9    Aster, J.C.10
  • 21
    • 84880074423 scopus 로고    scopus 로고
    • Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation
    • Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J (2013) Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem 288: 18219-18227
    • (2013) J Biol Chem , vol.288 , pp. 18219-18227
    • Kong, G.1    Du, J.2    Liu, Y.3    Meline, B.4    Chang, Y.I.5    Ranheim, E.A.6    Wang, J.7    Zhang, J.8
  • 22
    • 84882602512 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment
    • Hallek M (2013) Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment. Am J Hematol 88: 803-816
    • (2013) Am J Hematol , vol.88 , pp. 803-816
    • Hallek, M.1
  • 30
    • 0036884062 scopus 로고    scopus 로고
    • Molecular mechanisms of novel therapeutic approaches for multiple myeloma
    • Hideshima T, Anderson KC (2002) Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer 2: 927-937
    • (2002) Nat Rev Cancer , vol.2 , pp. 927-937
    • Hideshima, T.1    Anderson, K.C.2
  • 33
    • 84055213189 scopus 로고    scopus 로고
    • Notch signaling in acute lymphoblastic leukemia: Any role for stromal microenvironment?
    • Nwabo Kamdje AH, Krampera M (2011) Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment? Blood 118: 6506-6514
    • (2011) Blood , vol.118 , pp. 6506-6514
    • Nwabo Kamdje, A.H.1    Krampera, M.2
  • 35
    • 0035672773 scopus 로고    scopus 로고
    • Enhanced T-lineage acute lymphoblastic leukaemia cell survival on bone marrow stroma requires involvement of LFA-1 and ICAM-1
    • Winter SS, Sweatman JJ, Lawrence MB, Rhoades TH, Hart AL, Larson RS (2001) Enhanced T-lineage acute lymphoblastic leukaemia cell survival on bone marrow stroma requires involvement of LFA-1 and ICAM-1. Br J Haematol 115: 862-871
    • (2001) Br J Haematol , vol.115 , pp. 862-871
    • Winter, S.S.1    Sweatman, J.J.2    Lawrence, M.B.3    Rhoades, T.H.4    Hart, A.L.5    Larson, R.S.6
  • 36
    • 84874771894 scopus 로고    scopus 로고
    • Cross - Talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway
    • Zhang J, Ye J, Ma D, Liu N, Wu H, Yu S, Sun X, Tse W, Ji C (2013) Cross - talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway. Carcinogenesis 34: 667-677
    • (2013) Carcinogenesis , vol.34 , pp. 667-677
    • Zhang, J.1    Ye, J.2    Ma, D.3    Liu, N.4    Wu, H.5    Yu, S.6    Sun, X.7    Tse, W.8    Ji, C.9
  • 41
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J et al (2010) NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 28: 5-16
    • (2010) Stem Cells , vol.28 , pp. 5-16
    • Fan, X.1    Khaki, L.2    Zhu, T.S.3    Soules, M.E.4    Talsma, C.E.5    Gul, N.6    Koh, C.7    Zhang, J.8    Li, Y.M.9    Maciaczyk, J.10
  • 42
    • 84890718769 scopus 로고    scopus 로고
    • Roles of PINK1, mTORC 2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
    • Lee KS, Wu Z, Song Y, Mitra SS, Feroze AH, Cheshier SH, Lu B (2013) Roles of PINK1, mTORC 2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes Dev 27: 2642-2647
    • (2013) Genes Dev , vol.27 , pp. 2642-2647
    • Lee, K.S.1    Wu, Z.2    Song, Y.3    Mitra, S.S.4    Feroze, A.H.5    Cheshier, S.H.6    Lu, B.7
  • 43
    • 79953870540 scopus 로고    scopus 로고
    • Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies
    • Wang Y, Liu Y, Malek SN, Zheng P (2011) Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8: 399-411
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1    Liu, Y.2    Malek, S.N.3    Zheng, P.4
  • 47
    • 84873986676 scopus 로고    scopus 로고
    • gamma-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation
    • Rosati E, Sabatini R, De Falco F, Del Papa B, Falzetti F, Di Ianni M, Cavalli L, Fettucciari K, Bartoli A, Screpanti I et al (2013) gamma-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation. Int J Cancer 132: 1940-1953
    • (2013) Int J Cancer , vol.132 , pp. 1940-1953
    • Rosati, E.1    Sabatini, R.2    De Falco, F.3    Del Papa, B.4    Falzetti, F.5    Di Ianni, M.6    Cavalli, L.7    Fettucciari, K.8    Bartoli, A.9    Screpanti, I.10
  • 49
  • 54
    • 43149113910 scopus 로고    scopus 로고
    • Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
    • Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, Scoggin S, Fu T, Vien L, Histen G et al (2008) Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem 283: 8046-8054
    • (2008) J Biol Chem , vol.283 , pp. 8046-8054
    • Li, K.1    Li, Y.2    Wu, W.3    Gordon, W.R.4    Chang, D.W.5    Lu, M.6    Scoggin, S.7    Fu, T.8    Vien, L.9    Histen, G.10
  • 55
    • 79952240423 scopus 로고    scopus 로고
    • Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations
    • Fischer M, Yen WC, Kapoun AM, Wang M, O'Young G, Lewicki J, Gurney A, Hoey T (2011) Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Res 71: 1520-1525
    • (2011) Cancer Res , vol.71 , pp. 1520-1525
    • Fischer, M.1    Yen, W.C.2    Kapoun, A.M.3    Wang, M.4    O'Young, G.5    Lewicki, J.6    Gurney, A.7    Hoey, T.8
  • 57
    • 0035895087 scopus 로고    scopus 로고
    • A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer
    • Yan XQ, Sarmiento U, Sun Y, Huang G, Guo J, Juan T, Van G, Qi MY, Scully S, Senaldi G et al (2001) A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. Blood 98: 3793-3799
    • (2001) Blood , vol.98 , pp. 3793-3799
    • Yan, X.Q.1    Sarmiento, U.2    Sun, Y.3    Huang, G.4    Guo, J.5    Juan, T.6    Van, G.7    Qi, M.Y.8    Scully, S.9    Senaldi, G.10
  • 58
    • 84900809617 scopus 로고    scopus 로고
    • Brief overview of selected approaches in targeting pancreatic adenocarcinoma
    • Samore WR, Gondi CS (2014) Brief overview of selected approaches in targeting pancreatic adenocarcinoma. Expert Opin Investig Drugs 23: 793-807
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 793-807
    • Samore, W.R.1    Gondi, C.S.2
  • 60
    • 80054045386 scopus 로고    scopus 로고
    • Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL
    • Sulis ML, Saftig P, Ferrando AA (2011) Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL. Leukemia 25: 1564-1569
    • (2011) Leukemia , vol.25 , pp. 1564-1569
    • Sulis, M.L.1    Saftig, P.2    Ferrando, A.A.3
  • 61
    • 84902103433 scopus 로고    scopus 로고
    • Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia
    • Koyama D, Kikuchi J, Hiraoka N, Wada T, Kurosawa H, Chiba S, Furukawa Y (2014) Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia. Leukemia 28: 1216-1226
    • (2014) Leukemia , vol.28 , pp. 1216-1226
    • Koyama, D.1    Kikuchi, J.2    Hiraoka, N.3    Wada, T.4    Kurosawa, H.5    Chiba, S.6    Furukawa, Y.7
  • 67
    • 27144518462 scopus 로고    scopus 로고
    • Dose-dependent effects of the Notch ligand Delta 1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
    • Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID (2005) Dose-dependent effects of the Notch ligand Delta 1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood 106: 2693-2699
    • (2005) Blood , vol.106 , pp. 2693-2699
    • Delaney, C.1    Varnum-Finney, B.2    Aoyama, K.3    Brashem-Stein, C.4    Bernstein, I.D.5
  • 68
    • 16444377124 scopus 로고    scopus 로고
    • Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential
    • Lauret E, Catelain C, Titeux M, Poirault S, Dando JS, Dorsch M, Villeval JL, Groseil A, Vainchenker W, Sainteny F et al (2004) Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential. Leukemia 18: 788-797
    • (2004) Leukemia , vol.18 , pp. 788-797
    • Lauret, E.1    Catelain, C.2    Titeux, M.3    Poirault, S.4    Dando, J.S.5    Dorsch, M.6    Villeval, J.L.7    Groseil, A.8    Vainchenker, W.9    Sainteny, F.10
  • 69
    • 4944262287 scopus 로고    scopus 로고
    • Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo
    • Vercauteren SM, Sutherland HJ (2004) Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo. Blood 104: 2315-2322
    • (2004) Blood , vol.104 , pp. 2315-2322
    • Vercauteren, S.M.1    Sutherland, H.J.2
  • 70
    • 34548160939 scopus 로고    scopus 로고
    • Notch ligand Delta -1 differentially modulates the effects of gp130 activation on interleukin-6 receptor alpha-positive and-negative human hematopoietic progenitors
    • Yamamura K, Ohishi K, Katayama N, Kato K, Shibasaki T, Sugimoto Y, Miyata E, Shiku H, Masuya M, Nishioka J et al (2007) Notch ligand Delta -1 differentially modulates the effects of gp130 activation on interleukin-6 receptor alpha-positive and-negative human hematopoietic progenitors. Cancer Sci 98: 1597-1603
    • (2007) Cancer Sci , vol.98 , pp. 1597-1603
    • Yamamura, K.1    Ohishi, K.2    Katayama, N.3    Kato, K.4    Shibasaki, T.5    Sugimoto, Y.6    Miyata, E.7    Shiku, H.8    Masuya, M.9    Nishioka, J.10
  • 73
    • 33751551619 scopus 로고    scopus 로고
    • Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells
    • Lefort N, Benne C, Lelievre JD, Dorival C, Balbo M, Sakano S, Coulombel L, Levy Y (2006) Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells. Exp Hematol 34: 1720-1729
    • (2006) Exp Hematol , vol.34 , pp. 1720-1729
    • Lefort, N.1    Benne, C.2    Lelievre, J.D.3    Dorival, C.4    Balbo, M.5    Sakano, S.6    Coulombel, L.7    Levy, Y.8
  • 75
    • 2442522357 scopus 로고    scopus 로고
    • Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    • Tanigaki K, Tsuji M, Yamamoto N, Han H, Tsukada J, Inoue H, Kubo M, Honjo T (2004) Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20: 611-622
    • (2004) Immunity , vol.20 , pp. 611-622
    • Tanigaki, K.1    Tsuji, M.2    Yamamoto, N.3    Han, H.4    Tsukada, J.5    Inoue, H.6    Kubo, M.7    Honjo, T.8
  • 79
    • 0032904239 scopus 로고    scopus 로고
    • Notch 1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics
    • Carlesso N, Aster JC, Sklar J, Scadden DT (1999) Notch 1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood 93: 838-848
    • (1999) Blood , vol.93 , pp. 838-848
    • Carlesso, N.1    Aster, J.C.2    Sklar, J.3    Scadden, D.T.4
  • 80
    • 33846003463 scopus 로고    scopus 로고
    • Notch signaling induces apoptosis in primary human CD34+ hematopoietic progenitor cells
    • Chadwick N, Nostro MC, Baron M, Mottram R, Brady G, Buckle AM (2007) Notch signaling induces apoptosis in primary human CD34+ hematopoietic progenitor cells. Stem Cells 25: 203-210
    • (2007) Stem Cells , vol.25 , pp. 203-210
    • Chadwick, N.1    Nostro, M.C.2    Baron, M.3    Mottram, R.4    Brady, G.5    Buckle, A.M.6
  • 83
    • 84897904676 scopus 로고    scopus 로고
    • Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors
    • Benveniste P, Serra P, Dervovic D, Herer E, Knowles G, Mohtashami M, Zuniga-Pflucker JC (2014) Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. Blood 123: 1167-1177
    • (2014) Blood , vol.123 , pp. 1167-1177
    • Benveniste, P.1    Serra, P.2    Dervovic, D.3    Herer, E.4    Knowles, G.5    Mohtashami, M.6    Zuniga-Pflucker, J.C.7
  • 84
    • 76349113345 scopus 로고    scopus 로고
    • Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
    • Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID (2010) Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16: 232-236
    • (2010) Nat Med , vol.16 , pp. 232-236
    • Delaney, C.1    Heimfeld, S.2    Brashem-Stein, C.3    Voorhies, H.4    Manger, R.L.5    Bernstein, I.D.6
  • 86
    • 33744491522 scopus 로고    scopus 로고
    • C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation
    • Suh HC, Gooya J, Renn K, Friedman AD, Johnson PF, Keller JR (2006) C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation. Blood 107: 4308-4316
    • (2006) Blood , vol.107 , pp. 4308-4316
    • Suh, H.C.1    Gooya, J.2    Renn, K.3    Friedman, A.D.4    Johnson, P.F.5    Keller, J.R.6
  • 87
    • 0034613734 scopus 로고    scopus 로고
    • The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
    • Karanu FN, Murdoch B, Gallacher L, Wu DM, Koremoto M, Sakano S, Bhatia M (2000) The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med 192: 1365-1372
    • (2000) J Exp Med , vol.192 , pp. 1365-1372
    • Karanu, F.N.1    Murdoch, B.2    Gallacher, L.3    Wu, D.M.4    Koremoto, M.5    Sakano, S.6    Bhatia, M.7
  • 88
    • 0038528309 scopus 로고    scopus 로고
    • Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression
    • Schroeder T, Kohlhof H, Rieber N, Just U (2003) Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression. J Immunol 170: 5538-5548
    • (2003) J Immunol , vol.170 , pp. 5538-5548
    • Schroeder, T.1    Kohlhof, H.2    Rieber, N.3    Just, U.4
  • 90
    • 84861513958 scopus 로고    scopus 로고
    • Hemogenic endothelium during development and beyond
    • Hirschi KK (2012) Hemogenic endothelium during development and beyond. Blood 119: 4823-4827
    • (2012) Blood , vol.119 , pp. 4823-4827
    • Hirschi, K.K.1
  • 91
    • 42649104782 scopus 로고    scopus 로고
    • Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment
    • Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N et al (2008) Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Cell Stem Cell 2: 461-471
    • (2008) Cell Stem Cell , vol.2 , pp. 461-471
    • Yu, X.1    Zou, J.2    Ye, Z.3    Hammond, H.4    Chen, G.5    Tokunaga, A.6    Mali, P.7    Li, Y.M.8    Civin, C.9    Gaiano, N.10
  • 92
    • 58149235681 scopus 로고    scopus 로고
    • Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast
    • Cheng X, Huber TL, Chen VC, Gadue P, Keller GM (2008) Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development 135: 3447-3458
    • (2008) Development , vol.135 , pp. 3447-3458
    • Cheng, X.1    Huber, T.L.2    Chen, V.C.3    Gadue, P.4    Keller, G.M.5
  • 93
    • 33750566665 scopus 로고    scopus 로고
    • Notch signaling in stem cell systems
    • Chiba S (2006) Notch signaling in stem cell systems. Stem Cells 24: 2437-2447
    • (2006) Stem Cells , vol.24 , pp. 2437-2447
    • Chiba, S.1
  • 95
    • 84866534137 scopus 로고    scopus 로고
    • Cell signalling pathways that mediate haematopoietic stem cell specification
    • Marks-Bluth J, Pimanda JE (2012) Cell signalling pathways that mediate haematopoietic stem cell specification. Int J Biochem Cell Biol 44: 2175-2184
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 2175-2184
    • Marks-Bluth, J.1    Pimanda, J.E.2
  • 96
    • 37549020639 scopus 로고    scopus 로고
    • Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood
    • Nostro MC, Cheng X, Keller GM, Gadue P (2008) Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell 2: 60-71
    • (2008) Cell Stem Cell , vol.2 , pp. 60-71
    • Nostro, M.C.1    Cheng, X.2    Keller, G.M.3    Gadue, P.4
  • 99
    • 0031671642 scopus 로고    scopus 로고
    • A newly discovered class of human hematopoietic cells with SCID-repopulating activity
    • Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick JE (1998) A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med 4: 1038-1045
    • (1998) Nat Med , vol.4 , pp. 1038-1045
    • Bhatia, M.1    Bonnet, D.2    Murdoch, B.3    Gan, O.I.4    Dick, J.E.5
  • 101
    • 84871698997 scopus 로고    scopus 로고
    • T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures
    • Kennedy M, Awong G, Sturgeon CM, Ditadi A, LaMotte-Mohs R, Zuniga-Pflucker JC, Keller G (2012) T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Rep 2: 1722-1735
    • (2012) Cell Rep , vol.2 , pp. 1722-1735
    • Kennedy, M.1    Awong, G.2    Sturgeon, C.M.3    Ditadi, A.4    LaMotte-Mohs, R.5    Zuniga-Pflucker, J.C.6    Keller, G.7
  • 102
    • 84885612102 scopus 로고    scopus 로고
    • Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
    • Themeli M, Kloss CC, Ciriello G, Fedorov VD, Perna F, Gonen M, Sadelain M (2013) Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nat Biotechnol 31: 928-933
    • (2013) Nat Biotechnol , vol.31 , pp. 928-933
    • Themeli, M.1    Kloss, C.C.2    Ciriello, G.3    Fedorov, V.D.4    Perna, F.5    Gonen, M.6    Sadelain, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.