-
2
-
-
79951516547
-
Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
-
Paganin M, Ferrando A. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev 2011; 25: 83-90.
-
(2011)
Blood Rev
, vol.25
, pp. 83-90
-
-
Paganin, M.1
Ferrando, A.2
-
3
-
-
78649991073
-
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
-
Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol 2011; 223: 262-273.
-
(2011)
J Pathol
, vol.223
, pp. 262-273
-
-
Aster, J.C.1
Blacklow, S.C.2
Pear, W.S.3
-
5
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
DOI 10.1038/nrm2009, PII NRM2009
-
Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006; 7: 678-689. (Pubitemid 44268213)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.9
, pp. 678-689
-
-
Bray, S.J.1
-
6
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
DOI 10.1126/science.1102160
-
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269-271. (Pubitemid 39336870)
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, I.V.J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
7
-
-
33745045658
-
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
-
DOI 10.1128/MCB.01655-05
-
Malecki MJ, Sanchez-Irizarry C, Mitchell JL, Histen G, Xu ML, Aster JC et al. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol 2006; 26: 4642-4651. (Pubitemid 43877581)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.12
, pp. 4642-4651
-
-
Malecki, M.J.1
Sanchez-Irizarry, C.2
Mitchell, J.L.3
Histen, G.4
Xu, M.L.5
Aster, J.C.6
Blacklow, S.C.7
-
8
-
-
50949118936
-
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL
-
Sulis ML, Williams O, Palomero T, Tosello V, Pallikuppam S, Real PJ et al. NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL. Blood 2008; 112: 733-740.
-
(2008)
Blood
, vol.112
, pp. 733-740
-
-
Sulis, M.L.1
Williams, O.2
Palomero, T.3
Tosello, V.4
Pallikuppam, S.5
Real, P.J.6
-
9
-
-
53049085101
-
Oncogenic NOTCH1 control of MYC and PI3K: Challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas
-
Palomero T, Ferrando A. Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. Clin Cancer Res 2008; 14: 5314-5317.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5314-5317
-
-
Palomero, T.1
Ferrando, A.2
-
10
-
-
0343196671
-
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
-
DOI 10.1016/S0092-8674(00)80335-9
-
Pan D, Rubin GM. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997; 90: 271-280. (Pubitemid 27329712)
-
(1997)
Cell
, vol.90
, Issue.2
, pp. 271-280
-
-
Duojia, P.1
Rubin, G.M.2
-
11
-
-
0031457037
-
The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
-
Sotillos S, Roch F, Campuzano S. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 1997; 124: 4769-4779. (Pubitemid 28014380)
-
(1997)
Development
, vol.124
, Issue.23
, pp. 4769-4779
-
-
Sotillos, S.1
Roch, F.2
Campuzano, S.3
-
12
-
-
0031470904
-
SUP-17, a caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
-
Wen C, Metzstein MM, Greenwald I. SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling. Development 1997; 124: 4759-4767. (Pubitemid 28014379)
-
(1997)
Development
, vol.124
, Issue.23
, pp. 4759-4767
-
-
Wen, C.1
Metzstein, M.M.2
Greenwald, I.3
-
13
-
-
0033868818
-
A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
-
Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 2000; 5: 207-216. (Pubitemid 30628080)
-
(2000)
Molecular Cell
, vol.5
, Issue.2
, pp. 207-216
-
-
Brou, C.1
Logeat, F.2
Gupta, N.3
Bessia, C.4
Lebail, O.5
Doedens, J.R.6
Cumano, A.7
Roux, P.8
Black, R.A.9
Israel, A.10
-
14
-
-
0033867521
-
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
-
Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian X, Pan DJ et al. A ligand-induced extracellular cleavage regulates gammasecretase-like proteolytic activation of Notch1. Mol Cell 2000; 5: 197-206. (Pubitemid 30628079)
-
(2000)
Molecular Cell
, vol.5
, Issue.2
, pp. 197-206
-
-
Mumm, J.S.1
Schroeter, E.H.2
Saxena, M.T.3
Griesemer, A.4
Tian, X.5
Pan, D.J.6
Ray, W.J.7
Kopan, R.8
-
15
-
-
0036796421
-
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts
-
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W et al. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 2002; 11: 2615-2624. (Pubitemid 35174691)
-
(2002)
Human Molecular Genetics
, vol.11
, Issue.21
, pp. 2615-2624
-
-
Hartmann, D.1
De Strooper, B.2
Serneels, L.3
Craessaerts, K.4
Herreman, A.5
Annaert, W.6
Umans, L.7
Lubke, T.8
Illert, A.L.9
Von Figura, K.10
Saftig, P.11
-
16
-
-
18944406380
-
Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, Delta-1
-
Manilay JO, Anderson AC, Kang C, Robey EA. Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1. J Immunol 2005; 174: 6732-6741. (Pubitemid 40705635)
-
(2005)
Journal of Immunology
, vol.174
, Issue.11
, pp. 6732-6741
-
-
Manilay, J.O.1
Anderson, A.C.2
Kang, C.3
Robey, E.A.4
-
17
-
-
53749096966
-
ADAM10 is essential for proteolytic activation of Notch during thymocyte development
-
Tian L, Wu X, Chi C, Han M, Xu T, Zhuang Y. ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol 2008; 20: 1181-1187.
-
(2008)
Int Immunol
, vol.20
, pp. 1181-1187
-
-
Tian, L.1
Wu, X.2
Chi, C.3
Han, M.4
Xu, T.5
Zhuang, Y.6
-
18
-
-
71449113533
-
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
-
van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M. Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem 2009; 284: 31018-31027.
-
(2009)
J Biol Chem
, vol.284
, pp. 31018-31027
-
-
Van Tetering, G.1
Van Diest, P.2
Verlaan, I.3
Van Der Wall, E.4
Kopan, R.5
Vooijs, M.6
-
19
-
-
70350536784
-
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
-
Bozkulak EC, Weinmaster G. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol 2009; 29: 5679-5695.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5679-5695
-
-
Bozkulak, E.C.1
Weinmaster, G.2
-
20
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 2006; 124: 1283-1298.
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
Grueneberg, D.A.2
Yang, X.3
Kim, S.Y.4
Kloepfer, A.M.5
Hinkle, G.6
-
21
-
-
40749150603
-
Acute lymphoblastic leukaemia
-
DOI 10.1016/S0140-6736(08)60457-2, PII S0140673608604572
-
Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008; 371: 1030-1043. (Pubitemid 351389536)
-
(2008)
The Lancet
, vol.371
, Issue.9617
, pp. 1030-1043
-
-
Pui, C.-H.1
Robison, L.L.2
Look, A.T.3
-
22
-
-
58149336788
-
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
-
Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E et al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 2009; 15: 50-58.
-
(2009)
Nat Med
, vol.15
, pp. 50-58
-
-
Real, P.J.1
Tosello, V.2
Palomero, T.3
Castillo, M.4
Hernando, E.5
De Stanchina, E.6
-
23
-
-
33745203104
-
CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to γ-secretase inhibitors
-
DOI 10.1038/sj.leu.2404258, PII 2404258
-
Palomero T, Barnes KC, Real PJ, Glade Bender JL, Sulis ML, Murty VV et al. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. Leukemia 2006; 20: 1279-1287. (Pubitemid 43905832)
-
(2006)
Leukemia
, vol.20
, Issue.7
, pp. 1279-1287
-
-
Palomero, T.1
Barnes, K.C.2
Real, P.J.3
Glade Bender, J.L.4
Sulis, M.L.5
Murty, V.V.6
Colovai, A.I.7
Balbin, M.8
Ferrando, A.A.9
-
24
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y et al. Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464: 1052-1057.
-
(2010)
Nature
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
Cain-Hom, C.2
Choy, L.3
Hagenbeek, T.J.4
De Leon, G.P.5
Chen, Y.6
-
25
-
-
77949395629
-
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors
-
Aste-Amezaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M et al. Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS ONE 2010; 5: e9094.
-
(2010)
PLoS ONE
, vol.5
-
-
Aste-Amezaga, M.1
Zhang, N.2
Lineberger, J.E.3
Arnold, B.A.4
Toner, T.J.5
Gu, M.6
-
26
-
-
56749133149
-
The ADAMs: Signalling scissors in the tumour microenvironment
-
Murphy G. The ADAMs: signalling scissors in the tumour microenvironment. Nat Rev Cancer 2008; 8: 929-941.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 929-941
-
-
Murphy, G.1
-
27
-
-
11244261160
-
ADAMs: Key components in egfr signalling and development
-
DOI 10.1038/nrm1548
-
Blobel CP. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 2005; 6: 32-43. (Pubitemid 40064897)
-
(2005)
Nature Reviews Molecular Cell Biology
, vol.6
, Issue.1
, pp. 32-43
-
-
Blobel, C.P.1
-
28
-
-
33847718214
-
The EGF receptor family: Spearheading a merger of signaling and therapeutics
-
DOI 10.1016/j.ceb.2007.02.008, PII S0955067407000221
-
Bublil EM, Yarden Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol 2007; 19: 124-134. (Pubitemid 46386405)
-
(2007)
Current Opinion in Cell Biology
, vol.19
, Issue.2
, pp. 124-134
-
-
Bublil, E.M.1
Yarden, Y.2
-
29
-
-
33745791118
-
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
-
DOI 10.1016/j.ccr.2006.05.024, PII S1535610806001802
-
Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell 2006; 10: 39-50. (Pubitemid 44018087)
-
(2006)
Cancer Cell
, vol.10
, Issue.1
, pp. 39-50
-
-
Zhou, B.-B.S.1
Peyton, M.2
He, B.3
Liu, C.4
Girard, L.5
Caudler, E.6
Lo, Y.7
Baribaud, F.8
Mikami, I.9
Reguart, N.10
Yang, G.11
Li, Y.12
Yao, W.13
Vaddi, K.14
Gazdar, A.F.15
Friedman, S.M.16
Jablons, D.M.17
Newton, R.C.18
Fridman, J.S.19
Minna, J.D.20
Scherle, P.A.21
more..
-
30
-
-
33846817495
-
Targeting TACE-dependent EGFR ligand shedding in breast cancer
-
DOI 10.1172/JCI29518
-
Kenny PA, Bissell MJ. Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 2007; 117: 337-345. (Pubitemid 46203962)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.2
, pp. 337-345
-
-
Kenny, P.A.1
Bissell, M.J.2
|