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Volumn 21, Issue 9, 2014, Pages 1185-1195

Chemical biology tools for regulating RAS signaling complexity in space and time

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN; MOLECULAR LIBRARY;

EID: 84910051149     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.08.001     Document Type: Review
Times cited : (24)

References (80)
  • 2
    • 0034905234 scopus 로고    scopus 로고
    • Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines
    • A.A. Adjei, J.N. Davis, L.M. Bruzek, C. Erlichman, and S.H. Kaufmann Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines Clin. Cancer Res. 7 2001 1438 1445
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1438-1445
    • Adjei, A.A.1    Davis, J.N.2    Bruzek, L.M.3    Erlichman, C.4    Kaufmann, S.H.5
  • 4
    • 0034642495 scopus 로고    scopus 로고
    • Bioorganic synthesis of lipid-modified proteins for the study of signal transduction
    • B. Bader, K. Kuhn, D.J. Owen, H. Waldmann, A. Wittinghofer, and J. Kuhlmann Bioorganic synthesis of lipid-modified proteins for the study of signal transduction Nature 403 2000 223 226
    • (2000) Nature , vol.403 , pp. 223-226
    • Bader, B.1    Kuhn, K.2    Owen, D.J.3    Waldmann, H.4    Wittinghofer, A.5    Kuhlmann, J.6
  • 6
    • 0034625181 scopus 로고    scopus 로고
    • Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells
    • M.O. Bergo, G.K. Leung, P. Ambroziak, J.C. Otto, P.J. Casey, and S.G. Young Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells J. Biol. Chem. 275 2000 17605 17610
    • (2000) J. Biol. Chem. , vol.275 , pp. 17605-17610
    • Bergo, M.O.1    Leung, G.K.2    Ambroziak, P.3    Otto, J.C.4    Casey, P.J.5    Young, S.G.6
  • 7
    • 80054866000 scopus 로고    scopus 로고
    • Targeting protein prenylation for cancer therapy
    • N. Berndt, A.D. Hamilton, and S.M. Sebti Targeting protein prenylation for cancer therapy Nat. Rev. Cancer 11 2011 775 791
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 775-791
    • Berndt, N.1    Hamilton, A.D.2    Sebti, S.M.3
  • 8
    • 0030909336 scopus 로고    scopus 로고
    • Modulation of Ras and a-factor function by carboxyl-terminal proteolysis
    • V.L. Boyartchuk, M.N. Ashby, and J. Rine Modulation of Ras and a-factor function by carboxyl-terminal proteolysis Science 275 1997 1796 1800
    • (1997) Science , vol.275 , pp. 1796-1800
    • Boyartchuk, V.L.1    Ashby, M.N.2    Rine, J.3
  • 10
    • 0028857006 scopus 로고
    • Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos
    • L. Buday, P.H. Warne, and J. Downward Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos Oncogene 11 1995 1327 1331
    • (1995) Oncogene , vol.11 , pp. 1327-1331
    • Buday, L.1    Warne, P.H.2    Downward, J.3
  • 12
    • 77958527538 scopus 로고    scopus 로고
    • TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
    • P.M. Campbell, N. Boufaied, J.J. Fiordalisi, A.D. Cox, P. Falardeau, C.J. Der, and H. Gourdeau TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling J. Mol. Signal. 5 2010 18
    • (2010) J. Mol. Signal. , vol.5 , pp. 18
    • Campbell, P.M.1    Boufaied, N.2    Fiordalisi, J.J.3    Cox, A.D.4    Falardeau, P.5    Der, C.J.6    Gourdeau, H.7
  • 13
    • 84864012288 scopus 로고    scopus 로고
    • Negative feedback and adaptive resistance to the targeted therapy of cancer
    • S. Chandarlapaty Negative feedback and adaptive resistance to the targeted therapy of cancer Cancer Discov 2 2012 311 319
    • (2012) Cancer Discov , vol.2 , pp. 311-319
    • Chandarlapaty, S.1
  • 16
    • 17744415288 scopus 로고    scopus 로고
    • Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element
    • S. Chong, F.B. Mersha, D.G. Comb, M.E. Scott, D. Landry, L.M. Vence, F.B. Perler, J. Benner, R.B. Kucera, and C.A. Hirvonen Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element Gene 192 1997 271 281
    • (1997) Gene , vol.192 , pp. 271-281
    • Chong, S.1    Mersha, F.B.2    Comb, D.G.3    Scott, M.E.4    Landry, D.5    Vence, L.M.6    Perler, F.B.7    Benner, J.8    Kucera, R.B.9    Hirvonen, C.A.10
  • 17
    • 85015517666 scopus 로고    scopus 로고
    • COSMIC database. (2014). http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/.
    • (2014) COSMIC Database
  • 21
    • 0029939164 scopus 로고    scopus 로고
    • SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways
    • Dong Chen, S.B. Waters, K.H. Holt, and J.E. Pessin SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways J. Biol. Chem. 271 1996 6328 6332
    • (1996) J. Biol. Chem. , vol.271 , pp. 6328-6332
    • Chen, D.1    Waters, S.B.2    Holt, K.H.3    Pessin, J.E.4
  • 22
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • J. Downward Targeting RAS signalling pathways in cancer therapy Nat. Rev. Cancer 3 2003 11 22
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 23
    • 4544295231 scopus 로고    scopus 로고
    • Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity
    • G. Elad-Sfadia, R. Haklai, E. Balan, and Y. Kloog Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity J. Biol. Chem. 279 2004 34922 34930
    • (2004) J. Biol. Chem. , vol.279 , pp. 34922-34930
    • Elad-Sfadia, G.1    Haklai, R.2    Balan, E.3    Kloog, Y.4
  • 24
    • 84906938439 scopus 로고    scopus 로고
    • Oncogenic KRAS signalling in pancreatic cancer
    • Published online April 22, 2014
    • S. Eser, A. Schnieke, G. Schneider, and D. Saur Oncogenic KRAS signalling in pancreatic cancer Br. J. Cancer 2014 10.1038/bjc.2014.215 Published online April 22, 2014
    • (2014) Br. J. Cancer
    • Eser, S.1    Schnieke, A.2    Schneider, G.3    Saur, D.4
  • 29
    • 84870505131 scopus 로고    scopus 로고
    • Is there a future for prenyltransferase inhibitors in cancer therapy?
    • S.A. Holstein, and R.J. Hohl Is there a future for prenyltransferase inhibitors in cancer therapy? Curr. Opin. Pharmacol. 12 2012 704 709
    • (2012) Curr. Opin. Pharmacol. , vol.12 , pp. 704-709
    • Holstein, S.A.1    Hohl, R.J.2
  • 30
    • 0025764049 scopus 로고
    • The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins
    • C.A. Hrycyna, S.K. Sapperstein, S. Clarke, and S. Michaelis The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins EMBO J. 10 1991 1699 1709
    • (1991) EMBO J. , vol.10 , pp. 1699-1709
    • Hrycyna, C.A.1    Sapperstein, S.K.2    Clarke, S.3    Michaelis, S.4
  • 31
    • 85015521615 scopus 로고    scopus 로고
    • Kirax Corporation. (2014). http://kiraxcorp.com/ggti2418.html.
    • (2014) Kirax Corporation
  • 34
    • 54949147613 scopus 로고    scopus 로고
    • Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis
    • S.R. Jada, C. Matthews, M.S. Saad, A.S. Hamzah, N.H. Lajis, M.F. Stevens, and J. Stanslas Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis Br. J. Pharmacol. 155 2008 641 654
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 641-654
    • Jada, S.R.1    Matthews, C.2    Saad, M.S.3    Hamzah, A.S.4    Lajis, N.H.5    Stevens, M.F.6    Stanslas, J.7
  • 35
    • 0037945026 scopus 로고    scopus 로고
    • Use of synthetic isoprenoid analogues for understanding protein prenyltransferase mechanism and structure
    • T.A. Kale, S.A. Hsieh, M.W. Rose, and M.D. Distefano Use of synthetic isoprenoid analogues for understanding protein prenyltransferase mechanism and structure Curr. Top. Med. Chem. 3 2003 1043 1074
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 1043-1074
    • Kale, T.A.1    Hsieh, S.A.2    Rose, M.W.3    Distefano, M.D.4
  • 36
    • 0034969995 scopus 로고    scopus 로고
    • Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins
    • A. Kalinin, N.H. Thomä, A. Iakovenko, I. Heinemann, E. Rostkova, A.T. Constantinescu, and K. Alexandrov Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins Protein Expr. Purif. 22 2001 84 91
    • (2001) Protein Expr. Purif. , vol.22 , pp. 84-91
    • Kalinin, A.1    Thomä, N.H.2    Iakovenko, A.3    Heinemann, I.4    Rostkova, E.5    Constantinescu, A.T.6    Alexandrov, K.7
  • 37
    • 64649106561 scopus 로고    scopus 로고
    • Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: Implications for breast cancer therapy
    • A. Kazi, A. Carie, M.A. Blaskovich, C. Bucher, V. Thai, S. Moulder, H. Peng, D. Carrico, E. Pusateri, and W.J. Pledger Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy Mol. Cell. Biol. 29 2009 2254 2263
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2254-2263
    • Kazi, A.1    Carie, A.2    Blaskovich, M.A.3    Bucher, C.4    Thai, V.5    Moulder, S.6    Peng, H.7    Carrico, D.8    Pusateri, E.9    Pledger, W.J.10
  • 40
    • 84887478023 scopus 로고    scopus 로고
    • Tumor adaptation and resistance to RAF inhibitors
    • P. Lito, N. Rosen, and D.B. Solit Tumor adaptation and resistance to RAF inhibitors Nat. Med. 19 2013 1401 1409
    • (2013) Nat. Med. , vol.19 , pp. 1401-1409
    • Lito, P.1    Rosen, N.2    Solit, D.B.3
  • 41
    • 18844469801 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I
    • R.B. Lobell, D. Liu, C.A. Buser, J.P. Davide, E. DePuy, K. Hamilton, K.S. Koblan, Y. Lee, S. Mosser, and S.L. Motzel Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I Mol. Cancer Ther. 1 2002 747 758
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 747-758
    • Lobell, R.B.1    Liu, D.2    Buser, C.A.3    Davide, J.P.4    Depuy, E.5    Hamilton, K.6    Koblan, K.S.7    Lee, Y.8    Mosser, S.9    Motzel, S.L.10
  • 46
    • 0028848171 scopus 로고
    • The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase
    • P. McGeady, S. Kuroda, K. Shimizu, Y. Takai, and M.H. Gelb The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase J. Biol. Chem. 270 1995 26347 26351
    • (1995) J. Biol. Chem. , vol.270 , pp. 26347-26351
    • McGeady, P.1    Kuroda, S.2    Shimizu, K.3    Takai, Y.4    Gelb, M.H.5
  • 47
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • J. Mendelsohn, and J. Baselga The EGF receptor family as targets for cancer therapy Oncogene 19 2000 6550 6565
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 48
    • 84887114555 scopus 로고    scopus 로고
    • The HER2 receptor in breast cancer: Pathophysiology, clinical use, and new advances in therapy
    • Z. Mitri, T. Constantine, and R. O'Regan The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy Chemother. Res. Pract. 2012 2012 743193
    • (2012) Chemother. Res. Pract. , vol.2012 , pp. 743193
    • Mitri, Z.1    Constantine, T.2    O'Regan, R.3
  • 49
    • 0025913902 scopus 로고
    • Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins
    • T. Noonan, N. Brown, L. Dudycz, and G. Wright Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins J. Med. Chem. 34 1991 1302 1307
    • (1991) J. Med. Chem. , vol.34 , pp. 1302-1307
    • Noonan, T.1    Brown, N.2    Dudycz, L.3    Wright, G.4
  • 52
    • 84888639050 scopus 로고    scopus 로고
    • K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
    • J.M. Ostrem, U. Peters, M.L. Sos, J.A. Wells, and K.M. Shokat K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions Nature 503 2013 548 551
    • (2013) Nature , vol.503 , pp. 548-551
    • Ostrem, J.M.1    Peters, U.2    Sos, M.L.3    Wells, J.A.4    Shokat, K.M.5
  • 53
    • 0033605743 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian prenyl protein-specific protease
    • J.C. Otto, E. Kim, S.G. Young, and P.J. Casey Cloning and characterization of a mammalian prenyl protein-specific protease J. Biol. Chem. 274 1999 8379 8382
    • (1999) J. Biol. Chem. , vol.274 , pp. 8379-8382
    • Otto, J.C.1    Kim, E.2    Young, S.G.3    Casey, P.J.4
  • 55
    • 0035829731 scopus 로고    scopus 로고
    • Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation
    • A. Paz, R. Haklai, G. Elad-Sfadia, E. Ballan, and Y. Kloog Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation Oncogene 20 2001 7486 7493
    • (2001) Oncogene , vol.20 , pp. 7486-7493
    • Paz, A.1    Haklai, R.2    Elad-Sfadia, G.3    Ballan, E.4    Kloog, Y.5
  • 56
    • 0029935183 scopus 로고    scopus 로고
    • Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1
    • E. Porfiri, and F. McCormick Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1 J. Biol. Chem. 271 1996 5871 5877
    • (1996) J. Biol. Chem. , vol.271 , pp. 5871-5877
    • Porfiri, E.1    McCormick, F.2
  • 58
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of Ras mutations in cancer
    • I.A. Prior, P.D. Lewis, and C. Mattos A comprehensive survey of Ras mutations in cancer Cancer Res. 72 2012 2457 2467
    • (2012) Cancer Res. , vol.72 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 60
    • 33745745892 scopus 로고    scopus 로고
    • Spatio-temporal segregation of Ras signals: One ship, three anchors, many harbors
    • O. Rocks, A. Peyker, and P.I. Bastiaens Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors Curr. Opin. Cell Biol. 18 2006 351 357
    • (2006) Curr. Opin. Cell Biol. , vol.18 , pp. 351-357
    • Rocks, O.1    Peyker, A.2    Bastiaens, P.I.3
  • 64
    • 84898606304 scopus 로고    scopus 로고
    • KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport
    • M. Schmick, N. Vartak, B. Papke, M. Kovacevic, D.C. Truxius, L. Rossmannek, and P.I. Bastiaens KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport Cell 157 2014 459 471
    • (2014) Cell , vol.157 , pp. 459-471
    • Schmick, M.1    Vartak, N.2    Papke, B.3    Kovacevic, M.4    Truxius, D.C.5    Rossmannek, L.6    Bastiaens, P.I.7
  • 66
    • 0035835824 scopus 로고    scopus 로고
    • PTEN: Life as a tumor suppressor
    • L. Simpson, and R. Parsons PTEN: life as a tumor suppressor Exp. Cell Res. 264 2001 29 41
    • (2001) Exp. Cell Res. , vol.264 , pp. 29-41
    • Simpson, L.1    Parsons, R.2
  • 67
    • 0037400975 scopus 로고    scopus 로고
    • A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
    • K.S. Smalley A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int. J. Cancer 104 2003 527 532
    • (2003) Int. J. Cancer , vol.104 , pp. 527-532
    • Smalley, K.S.1
  • 68
    • 84904721890 scopus 로고    scopus 로고
    • Small molecule modulation of Ras signaling - The Holy Grail in anti-cancer drug discovery?
    • J. Spiegel, P.M. Cromm, G. Zimmermann, T.N. Grossmann, and H. Waldmann Small molecule modulation of Ras signaling - The Holy Grail in anti-cancer drug discovery? Nat. Chem. Biol. 10 2014 613 622
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 613-622
    • Spiegel, J.1    Cromm, P.M.2    Zimmermann, G.3    Grossmann, T.N.4    Waldmann, H.5
  • 73
    • 84865463399 scopus 로고    scopus 로고
    • Ras inhibition via direct Ras binding - Is there a path forward?
    • W. Wang, G. Fang, and J. Rudolph Ras inhibition via direct Ras binding - is there a path forward? Bioorg. Med. Chem. Lett. 22 2012 5766 5776
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 5766-5776
    • Wang, W.1    Fang, G.2    Rudolph, J.3
  • 74
    • 0033605482 scopus 로고    scopus 로고
    • Hyperactive Ras as a therapeutic target in neurofibromatosis type 1
    • B. Weiss, G. Bollag, and K. Shannon Hyperactive Ras as a therapeutic target in neurofibromatosis type 1 Am. J. Med. Genet. 89 1999 14 22
    • (1999) Am. J. Med. Genet. , vol.89 , pp. 14-22
    • Weiss, B.1    Bollag, G.2    Shannon, K.3
  • 75
    • 84872853570 scopus 로고    scopus 로고
    • Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
    • A. Young, D. Lou, and F. McCormick Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling Cancer Discov 3 2013 112 123
    • (2013) Cancer Discov , vol.3 , pp. 112-123
    • Young, A.1    Lou, D.2    McCormick, F.3
  • 76
    • 34547480479 scopus 로고    scopus 로고
    • Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments
    • H. Zhang, S. Li, T. Doan, F. Rieke, P.B. Detwiler, J.M. Frederick, and W. Baehr Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments Proc. Natl. Acad. Sci. USA 104 2007 8857 8862
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 8857-8862
    • Zhang, H.1    Li, S.2    Doan, T.3    Rieke, F.4    Detwiler, P.B.5    Frederick, J.M.6    Baehr, W.7
  • 77
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • S. Zimmermann, and K. Moelling Phosphorylation and regulation of Raf by Akt (protein kinase B) Science 286 1999 1741 1744
    • (1999) Science , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2


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