Therapeutic targeting of oncogenic K-ras by a covalent catalytic site inhibitor

Angewandte Chemie - International Edition

Volumn 53, Issue 1, 2014, Pages 199-204

  Lim, Sang Min ^a,b,e   Westover, Kenneth D ^c   Ficarro, Scott B ^a   Harrison, Rane A ^d   Choi, Hwan Geun ^a,b   Pacold, Michael E ^a,f   Carrasco, Martin ^c   Hunter, John ^c   Kim, Nam Doo ^g   Xie, Ting ^a,b,e   Sim, Taebo ^h   Jänne, Pasi A ^a   Meyerson, Matthew ^a,b,i   Marto, Jarrod A ^a   Engen, John R ^d   Gray, Nathanael S ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

^e HARVARD UNIVERSITY   (United States)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^g Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

^h Korea Institute of Science and Technology   (South Korea)

ⁱ BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

cancer; covalent inhibitors; drug design; K Ras

Indexed keywords

CANCER; CATALYTIC SITES; DRUG DESIGN; K-RAS; K-RAS INHIBITORS; PRODRUGS; THERAPEUTIC STRATEGY; WILD TYPES;

NUCLEOTIDES; POSITIVE IONS; PROTEINS;

BINDING SITES;

RAS PROTEIN;

ARTICLE; CHEMISTRY; COVALENT INHIBITORS; DRUG DESIGN; ENZYME ACTIVE SITE; GENETICS; K-RAS; METABOLISM; NEOPLASM; SIGNAL TRANSDUCTION;

CANCER; COVALENT INHIBITORS; DRUG DESIGN; K-RAS;

CATALYTIC DOMAIN; DRUG DESIGN; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 84890947640     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201307387     Document Type: Article

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