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Volumn 104, Issue 5, 2003, Pages 527-532

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 0037400975     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10978     Document Type: Short Survey
Times cited : (305)

References (120)
  • 1
    • 0032947058 scopus 로고    scopus 로고
    • MAP kinase pathways
    • Cobb MH. MAP kinase pathways. Prog Biophys Mol Biol 1999;71:479-500.
    • (1999) Prog Biophys Mol Biol , vol.71 , pp. 479-500
    • Cobb, M.H.1
  • 2
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000;351:289-305.
    • (2000) Biochem J , vol.351 , pp. 289-305
    • Kolch, W.1
  • 4
    • 0026641090 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro
    • 192
    • Dent P, Haser W, Haystead TA, Vincent LA, Roberts TM, Sturgill TW. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science 192;257:1404-7.
    • Science , vol.257 , pp. 1404-1407
    • Dent, P.1    Haser, W.2    Haystead, T.A.3    Vincent, L.A.4    Roberts, T.M.5    Sturgill, T.W.6
  • 5
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 1992;258:478-80.
    • (1992) Science , vol.258 , pp. 478-480
    • Crews, C.M.1    Alessandrini, A.2    Erikson, R.L.3
  • 7
    • 0027283659 scopus 로고
    • Growth factors induce nuclear translocation of MAP kinase (p42MAPK and p44MAPK) but not their activator MAP kinase kinase (p45MAPKK) in fibroblasts
    • Lenormand P, Sardet C, Pages G, L'allemain G, Brunet A, Pouyssegur J. Growth factors induce nuclear translocation of MAP kinase (p42MAPK and p44MAPK) but not their activator MAP kinase kinase (p45MAPKK) in fibroblasts. J Cell Biol 1993;122:1079-88.
    • (1993) J Cell Biol , vol.122 , pp. 1079-1088
    • Lenormand, P.1    Sardet, C.2    Pages, G.3    L'allemain, G.4    Brunet, A.5    Pouyssegur, J.6
  • 8
    • 0028084337 scopus 로고
    • Ternary comples factors: Growth factor regulated transcriptional activators
    • Treisman R. Ternary comples factors: growth factor regulated transcriptional activators. Curr Opin Genet Dev 1994;4:96-101.
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 96-101
    • Treisman, R.1
  • 9
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley S, Paterson H, Kemp P, Marshall CJ. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994;77:841-52.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 11
    • 0034617367 scopus 로고    scopus 로고
    • The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alphaMSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells
    • Smalley K, Eisen T. The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alphaMSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells. FEBS Lett 2000;476:198-202.
    • (2000) FEBS Lett , vol.476 , pp. 198-202
    • Smalley, K.1    Eisen, T.2
  • 12
    • 0035999075 scopus 로고    scopus 로고
    • Differentiation of human melanoma cells through p38 MAP kinase is associated with decreased retinoblastoma protein phosphorylation and cell cycle arrest
    • Smalley KSM, Eisen T. Differentiation of human melanoma cells through p38 MAP kinase is associated with decreased retinoblastoma protein phosphorylation and cell cycle arrest. Melanoma Res 2002;12:187-92.
    • (2002) Melanoma Res , vol.12 , pp. 187-192
    • Smalley, K.S.M.1    Eisen, T.2
  • 13
  • 14
    • 0037188432 scopus 로고    scopus 로고
    • U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells
    • Ge X, Fu YM, Meadows GG. U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells. Cancer Lett 2002;179:133-40.
    • (2002) Cancer Lett , vol.179 , pp. 133-140
    • Ge, X.1    Fu, Y.M.2    Meadows, G.G.3
  • 16
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 17
    • 0029199911 scopus 로고
    • Analysis of N-Ras mutations in human cutaneous melanoma: Tumour heterogeneity detected by polymerase chain reaction/single-stranded conformation polymerism analysis
    • van Elsas A, Zerp S, van der Flier S, Kruse-Wolters M, Vacca A, Ruiter DJ, Schrier P. Analysis of N-Ras mutations in human cutaneous melanoma: tumour heterogeneity detected by polymerase chain reaction/single-stranded conformation polymerism analysis. Rec Results Cancer Res 1995;139:57-67.
    • (1995) Rec Results Cancer Res , vol.139 , pp. 57-67
    • Van Elsas, A.1    Zerp, S.2    Van der Flier, S.3    Kruse-Wolters, M.4    Vacca, A.5    Ruiter, D.J.6    Schrier, P.7
  • 18
    • 0034085811 scopus 로고    scopus 로고
    • Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
    • Tsao H, Zhang X, Fowlkes K, Haluska FG. Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res 2000;60:1800-4.
    • (2000) Cancer Res , vol.60 , pp. 1800-1804
    • Tsao, H.1    Zhang, X.2    Fowlkes, K.3    Haluska, F.G.4
  • 19
    • 0028086086 scopus 로고
    • Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi
    • Carr J, MacKie RM. Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi. Br J Dermatol 1994;131:72-7.
    • (1994) Br J Dermatol , vol.131 , pp. 72-77
    • Carr, J.1    MacKie, R.M.2
  • 21
    • 0021228230 scopus 로고
    • A novel transforming gene in a human malignant melanoma cell line
    • Padua RA, Barrass N, Currie GA. A novel transforming gene in a human malignant melanoma cell line. Nature 1984;311:671-3.
    • (1984) Nature , vol.311 , pp. 671-673
    • Padua, R.A.1    Barrass, N.2    Currie, G.A.3
  • 22
    • 0027457349 scopus 로고
    • Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors
    • Storm SM, Rapp UR. Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors. Toxicol Lett 1993;67:201-10.
    • (1993) Toxicol Lett , vol.67 , pp. 201-210
    • Storm, S.M.1    Rapp, U.R.2
  • 26
    • 0026487199 scopus 로고
    • Malignant transformation of human melanocytes: Induction of a complete melanoma phenotype and genotype
    • Albino AP, Sozzi G, Nanus DM, Jhanwar SC, Houghton AN. Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype. Oncogene 1992;7:2315-21.
    • (1992) Oncogene , vol.7 , pp. 2315-2321
    • Albino, A.P.1    Sozzi, G.2    Nanus, D.M.3    Jhanwar, S.C.4    Houghton, A.N.5
  • 27
    • 0029889370 scopus 로고    scopus 로고
    • Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene
    • Donatien PD, Diment SL, Boissy RE, Orlow SJ. Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene. Int J Cancer 1996;66:557-63.
    • (1996) Int J Cancer , vol.66 , pp. 557-563
    • Donatien, P.D.1    Diment, S.L.2    Boissy, R.E.3    Orlow, S.J.4
  • 28
    • 0028951685 scopus 로고
    • Hyperpigmentation of and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-Ras gene regulated by a mouse tyrosinase promoter
    • Powell MB, Hyman P, Bell OD, Balmain A, Brown K, Alberts D, Bowden GT. Hyperpigmentation of and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-Ras gene regulated by a mouse tyrosinase promoter. Mol Carcinogen 1995;12:82-90.
    • (1995) Mol Carcinogen , vol.12 , pp. 82-90
    • Powell, M.B.1    Hyman, P.2    Bell, O.D.3    Balmain, A.4    Brown, K.5    Alberts, D.6    Bowden, G.T.7
  • 31
    • 0028324596 scopus 로고
    • Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes
    • Mattei S, Colombo MP, Melani C, Silvani A, Parmiani G, Herlyn M. Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes. Int J Cancer 1994;56:853-7.
    • (1994) Int J Cancer , vol.56 , pp. 853-857
    • Mattei, S.1    Colombo, M.P.2    Melani, C.3    Silvani, A.4    Parmiani, G.5    Herlyn, M.6
  • 32
    • 0342646934 scopus 로고    scopus 로고
    • Autocrine and paracrine regulation by cytokines and growth factors in melanoma
    • Lazar-Molnar E, Hegyesi H, Toth S, Falus A. Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine 2000;12:547-54.
    • (2000) Cytokine , vol.12 , pp. 547-554
    • Lazar-Molnar, E.1    Hegyesi, H.2    Toth, S.3    Falus, A.4
  • 34
    • 0035477424 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways
    • Satyamoorthy K, Li G, Vaidya B, Patel D. Herlyn M. Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways. Cancer Res 2001;61:7318-24.
    • (2001) Cancer Res , vol.61 , pp. 7318-7324
    • Satyamoorthy, K.1    Li, G.2    Vaidya, B.3    Patel, D.4    Herlyn, M.5
  • 35
    • 0028846891 scopus 로고
    • Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells
    • Englaro W, Rezzonico R, Durand-Clement M, Lallemand D, Ortonne JP, Ballotti R. Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells. J Biol Chem 1995;270:24315-20.
    • (1995) J Biol Chem , vol.270 , pp. 24315-24320
    • Englaro, W.1    Rezzonico, R.2    Durand-Clement, M.3    Lallemand, D.4    Ortonne, J.P.5    Ballotti, R.6
  • 36
    • 0029083694 scopus 로고
    • Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells
    • Erhardt P, Troppmeir J, Rapp UR, Cooper GM. Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells. Mol Cell Biol 1995;15:5524-30.
    • (1995) Mol Cell Biol , vol.15 , pp. 5524-5530
    • Erhardt, P.1    Troppmeir, J.2    Rapp, U.R.3    Cooper, G.M.4
  • 38
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995;9:1149-63.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 39
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994;78:59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 40
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ. G1 phase progression: cycling on cue. Cell 1994;79:551-5.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 41
    • 0021719520 scopus 로고
    • Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells
    • Feramisco JR, Gross M, Kamata T, Rosenberg M, Sweet RW. Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells. Cell 1984;38:109-17.
    • (1984) Cell , vol.38 , pp. 109-117
    • Feramisco, J.R.1    Gross, M.2    Kamata, T.3    Rosenberg, M.4    Sweet, R.W.5
  • 44
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK41
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK41. Cell 1997;88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 45
    • 0024026804 scopus 로고    scopus 로고
    • Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation
    • Ridley AJ, Paterson HF, Noble M, Land H. Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation. EMBO J 1998:7:1635-45.
    • (1998) EMBO J , vol.7 , pp. 1635-1645
    • Ridley, A.J.1    Paterson, H.F.2    Noble, M.3    Land, H.4
  • 46
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip
    • Sewing A, Wiseman B, Lloyd AC, Land H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip. Mol Cell Biol 1997;17:5588-97.
    • (1997) Mol Cell Biol , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 47
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation of cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
    • Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M. Raf-induced proliferation of cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 1997;17:5598-611.
    • (1997) Mol Cell Biol , vol.17 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 48
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998;12:3008-19.
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    Van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 50
    • 0029833974 scopus 로고    scopus 로고
    • Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesions
    • Papp T, Jafari M, Schiffmann D. Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesions. J Cancer Res Clin Oncol 1996;122:541-8.
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 541-548
    • Papp, T.1    Jafari, M.2    Schiffmann, D.3
  • 53
    • 0030240165 scopus 로고    scopus 로고
    • Activated Ras: Yet another player in melanoma?
    • Herlyn M, Satyamoorthy K. Activated Ras: yet another player in melanoma? Am J Pathol 1996;149:739-44.
    • (1996) Am J Pathol , vol.149 , pp. 739-744
    • Herlyn, M.1    Satyamoorthy, K.2
  • 55
    • 0033037541 scopus 로고    scopus 로고
    • The INK4A/ARF locus and its two gene products
    • Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev 1999;9:22-30.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 22-30
    • Sharpless, N.E.1    DePinho, R.A.2
  • 56
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-7.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 57
    • 0029670689 scopus 로고    scopus 로고
    • Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes
    • Imokawa G, Yada Y, Kimura M, Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes. Biochem J 1996;314:305-12.
    • (1996) Biochem J , vol.314 , pp. 305-312
    • Imokawa, G.1    Yada, Y.2    Kimura, M.3
  • 58
    • 0034721611 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via transactivation of the tyrosine kinase c-kit receptor
    • Imokawa G, Kobayasi T, Miyagishi M. Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via transactivation of the tyrosine kinase c-kit receptor. J Biol Chem 2000;275:33321-8.
    • (2000) J Biol Chem , vol.275 , pp. 33321-33328
    • Imokawa, G.1    Kobayasi, T.2    Miyagishi, M.3
  • 62
    • 0036533441 scopus 로고    scopus 로고
    • Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects
    • Smalley KSM, Eisen TG. Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. Int J Cancer 2002;98:514-22.
    • (2002) Int J Cancer , vol.98 , pp. 514-522
    • Smalley, K.S.M.1    Eisen, T.G.2
  • 63
    • 0037431539 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells
    • in press
    • Smalley KSM, Eisen TG. The farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. Int J Cancer, in press.
    • Int J Cancer
    • Smalley, K.S.M.1    Eisen, T.G.2
  • 65
    • 0029116211 scopus 로고
    • Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein
    • Medrano EE, Im S, Yang F, Abdel-Malek ZA. Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein. Cancer Res 1995;55:4047-52.
    • (1995) Cancer Res , vol.55 , pp. 4047-4052
    • Medrano, E.E.1    Im, S.2    Yang, F.3    Abdel-Malek, Z.A.4
  • 67
    • 0029775645 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation
    • Busca R, Bertolotto C, Ortonne JP, Ballotti R. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation. J Biol Chem 1996;271:31824-30.
    • (1996) J Biol Chem , vol.271 , pp. 31824-31830
    • Busca, R.1    Bertolotto, C.2    Ortonne, J.P.3    Ballotti, R.4
  • 68
    • 0016314575 scopus 로고
    • Response of mouse melanoma cells to melanocyte stimulating hormone
    • Wong G, Pawelek J, Sansome M, Morowitz J. Response of mouse melanoma cells to melanocyte stimulating hormone. Nature 1974;248:351-4.
    • (1974) Nature , vol.248 , pp. 351-354
    • Wong, G.1    Pawelek, J.2    Sansome, M.3    Morowitz, J.4
  • 72
    • 0036094340 scopus 로고    scopus 로고
    • Cyclic AMP blocks cell growth through Raf-1 dependent and Raf-1 and independent mechanisms
    • Dumaz N, Light Y, Marais R. Cyclic AMP blocks cell growth through Raf-1 dependent and Raf-1 and independent mechanisms. Mol Cell Biol 2002;22:3717-28.
    • (2002) Mol Cell Biol , vol.22 , pp. 3717-3728
    • Dumaz, N.1    Light, Y.2    Marais, R.3
  • 73
    • 0034661187 scopus 로고    scopus 로고
    • Mitf from neural crest to melanoma: Signal transduction and transcription in the melanocyte lineage
    • Goding CR. Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage. Genes Dev 2000;14:1712-28.
    • (2000) Genes Dev , vol.14 , pp. 1712-1728
    • Goding, C.R.1
  • 74
    • 0035088738 scopus 로고    scopus 로고
    • Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes
    • Yanase H, Ando H, Horikawa M, Watanabe M, Mori T, Matsuda N. Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes Pigment Cell Res 2001;14:103-9.
    • (2001) Pigment Cell Res , vol.14 , pp. 103-109
    • Yanase, H.1    Ando, H.2    Horikawa, M.3    Watanabe, M.4    Mori, T.5    Matsuda, N.6
  • 76
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase linkes the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE. MAP kinase linkes the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 1998;391:298-301.
    • (1998) Nature , vol.391 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 77
    • 0032540355 scopus 로고    scopus 로고
    • Inhibition of the mitogen activated protein kinase pathway triggers B16 melanoma cell differentiation
    • Englaro W, Bertolotto C, Busca R, Brunet A, Pages G, Ortonne J-P, Ballotti R. Inhibition of the mitogen activated protein kinase pathway triggers B16 melanoma cell differentiation. J Biol Chem 1998;273:9966-70.
    • (1998) J Biol Chem , vol.273 , pp. 9966-9970
    • Englaro, W.1    Bertolotto, C.2    Busca, R.3    Brunet, A.4    Pages, G.5    Ortonne, J.-P.6    Ballotti, R.7
  • 78
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995;80:179-85.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 80
    • 0027966022 scopus 로고
    • A gene for Waardenburg syndrome type 2 maps close to the human homologue of the human micropthalmia gene at chromosome 3p12-p141
    • Hughes AE, Newton VE, Liu XZ, Read AP. A gene for Waardenburg syndrome type 2 maps close to the human homologue of the human micropthalmia gene at chromosome 3p12-p141. Nat Genet 1994;7:509-512.
    • (1994) Nat Genet , vol.7 , pp. 509-512
    • Hughes, A.E.1    Newton, V.E.2    Liu, X.Z.3    Read, A.P.4
  • 81
    • 0035038927 scopus 로고    scopus 로고
    • Sensorineural deafness and pigmentation genes: Melanocytes and the Mitf transcriptional network
    • Price ER, Fisher DE. Sensorineural deafness and pigmentation genes: melanocytes and the Mitf transcriptional network. Neuron 2001;30:15-8.
    • (2001) Neuron , vol.30 , pp. 15-18
    • Price, E.R.1    Fisher, D.E.2
  • 84
    • 0032937232 scopus 로고    scopus 로고
    • Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
    • Rimm DL, Caca K, Hu G, Harrison FB, Fearon ER. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 1999;154:325-9.
    • (1999) Am J Pathol , vol.154 , pp. 325-329
    • Rimm, D.L.1    Caca, K.2    Hu, G.3    Harrison, F.B.4    Fearon, E.R.5
  • 85
    • 0037119948 scopus 로고    scopus 로고
    • β-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    • Widlund HR, Horstmann MA, Price ER, Cui J, Lessnick SL, Wu M, He X, Fisher DE. β-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol 2002;158:1079-87.
    • (2002) J Cell Biol , vol.158 , pp. 1079-1087
    • Widlund, H.R.1    Horstmann, M.A.2    Price, E.R.3    Cui, J.4    Lessnick, S.L.5    Wu, M.6    He, X.7    Fisher, D.E.8
  • 86
    • 0037022666 scopus 로고    scopus 로고
    • Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase
    • Koo HM, VanBrocklin M, McWilliams MJ, Leppla SH, Duesbery NS, Woude GF. Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. Proc Natl Acad Sci USA 2002;99:3052-7.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3052-3057
    • Koo, H.M.1    VanBrocklin, M.2    McWilliams, M.J.3    Leppla, S.H.4    Duesbery, N.S.5    Woude, G.F.6
  • 87
    • 0036379394 scopus 로고    scopus 로고
    • Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines
    • Eberle J, Fecker LF, Orfanos CE, Geilen CC. Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines. J Invest Dermatol 2002;119:549-55.
    • (2002) J Invest Dermatol , vol.119 , pp. 549-555
    • Eberle, J.1    Fecker, L.F.2    Orfanos, C.E.3    Geilen, C.C.4
  • 88
    • 0035135510 scopus 로고    scopus 로고
    • The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis
    • Mandic A, Viktorsson K, Heiden T, Hansson J, Shoshan MC. The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis. Melanoma Res 2001;11:11-9.
    • (2001) Melanoma Res , vol.11 , pp. 11-19
    • Mandic, A.1    Viktorsson, K.2    Heiden, T.3    Hansson, J.4    Shoshan, M.C.5
  • 89
    • 0033018943 scopus 로고    scopus 로고
    • Examining the relationship between the gelatinolytic balance and the invasive capacity of endothelial cells
    • Puyraimond A, Weitzman JB, Babiole E, Menashi S. Examining the relationship between the gelatinolytic balance and the invasive capacity of endothelial cells. J Cell Sci 1999;112:1283-90.
    • (1999) J Cell Sci , vol.112 , pp. 1283-1290
    • Puyraimond, A.1    Weitzman, J.B.2    Babiole, E.3    Menashi, S.4
  • 90
    • 0032927440 scopus 로고    scopus 로고
    • 'Proteolytic switching': Opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression
    • MacDougall JR, Bani MR, Lin Y, Muschel RJ, Kerbel RS. 'Proteolytic switching': opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression. Br J Cancer 1999;80:504-12.
    • (1999) Br J Cancer , vol.80 , pp. 504-512
    • MacDougall, J.R.1    Bani, M.R.2    Lin, Y.3    Muschel, R.J.4    Kerbel, R.S.5
  • 92
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999;147:89-104.
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • Aguirre Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 93
    • 0343517552 scopus 로고    scopus 로고
    • Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes
    • Santibanez JF, Iglesias M, Frontelo P, Martinez J, Quintanilla M. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes. Biochem Biophys Res Commun 2000;273:521-7.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 521-527
    • Santibanez, J.F.1    Iglesias, M.2    Frontelo, P.3    Martinez, J.4    Quintanilla, M.5
  • 94
    • 0034537138 scopus 로고    scopus 로고
    • Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: Involvement of Ras-dependent and -independent pathways
    • Genersch E, Hayess K, Neuenfeld Y, Haller H. Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways. J Cell Sci 2000;113:4319-30.
    • (2000) J Cell Sci , vol.113 , pp. 4319-4330
    • Genersch, E.1    Hayess, K.2    Neuenfeld, Y.3    Haller, H.4
  • 95
    • 0035986312 scopus 로고    scopus 로고
    • High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK 1/2 mitogen-activated kinase in VMM5 melanoma cells
    • Benbow U, Tower GB, Wyatt CA, Buttice G, Brinckerhoff CE. High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK 1/2 mitogen-activated kinase in VMM5 melanoma cells. J Cell Biochem 2002;86:307-19.
    • (2002) J Cell Biochem , vol.86 , pp. 307-319
    • Benbow, U.1    Tower, G.B.2    Wyatt, C.A.3    Buttice, G.4    Brinckerhoff, C.E.5
  • 96
    • 0037165697 scopus 로고    scopus 로고
    • Erk1/2 differentially regulates expression from the 1G/2G single nucleotide polymorphisms in melanoma cells
    • Tower GB, Coon CC, Benbow U, Vinceti MP, Brinckerhoff CE. Erk1/2 differentially regulates expression from the 1G/2G single nucleotide polymorphisms in melanoma cells. Biochim Biophys Acta 2002;1586:265-74.
    • (2002) Biochim Biophys Acta , vol.1586 , pp. 265-274
    • Tower, G.B.1    Coon, C.C.2    Benbow, U.3    Vinceti, M.P.4    Brinckerhoff, C.E.5
  • 97
    • 0036192304 scopus 로고    scopus 로고
    • An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells
    • Denkert C, Siegert A, Leclere A, Turzynski A, Hauptmann S. An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells. Clin Exp Metastasis 2002;19:79-85.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 79-85
    • Denkert, C.1    Siegert, A.2    Leclere, A.3    Turzynski, A.4    Hauptmann, S.5
  • 99
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 100
    • 0028670298 scopus 로고
    • Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
    • Montgomery AM, Reisfeld RA, Cheresh DA. Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci USA 1994;91:8856-60.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8856-8860
    • Montgomery, A.M.1    Reisfeld, R.A.2    Cheresh, D.A.3
  • 103
    • 0026775143 scopus 로고
    • Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments
    • Felding-Habermann B, Ruggeri ZM, Cheresh DA. Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments. J Biol Chem 1992;267:5070-7.
    • (1992) J Biol Chem , vol.267 , pp. 5070-5077
    • Felding-Habermann, B.1    Ruggeri, Z.M.2    Cheresh, D.A.3
  • 104
    • 0031596142 scopus 로고    scopus 로고
    • Role of the beta3 integrin subunit in human primary melanoma progression: Multifunctional activities associated with alpha(v)beta3 integrin expression
    • Seftor RE. Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression. Am J Pathol 1998;153:1347-51.
    • (1998) Am J Pathol , vol.153 , pp. 1347-1351
    • Seftor, R.E.1
  • 106
    • 0027157861 scopus 로고
    • Integrin expression in cutaneous malignant melanoma: Association of the alpha 3/beta 1 heterodimer with tumor progression
    • Natali PG, Nicotra MR, Bartolazzi A, Cavaliere R, Bigotti A. Integrin expression in cutaneous malignant melanoma: association of the alpha 3/beta 1 heterodimer with tumor progression. Int J Cancer 1993;54:68-72.
    • (1993) Int J Cancer , vol.54 , pp. 68-72
    • Natali, P.G.1    Nicotra, M.R.2    Bartolazzi, A.3    Cavaliere, R.4    Bigotti, A.5
  • 107
    • 0032814982 scopus 로고    scopus 로고
    • Ultrastructural localization of alpha-3 integrin subunit in malignant melanoma and adjacent epidermis
    • Schumacher D, Schaumburg-Lever G. Ultrastructural localization of alpha-3 integrin subunit in malignant melanoma and adjacent epidermis. J Cutan Pathol 1999;26:321-6.
    • (1999) J Cutan Pathol , vol.26 , pp. 321-326
    • Schumacher, D.1    Schaumburg-Lever, G.2
  • 109
    • 0034744538 scopus 로고    scopus 로고
    • Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated RafMEK-extracellular signal-regulated kinase signaling pathway
    • Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M. Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated RafMEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol 2001;21:3192-205.
    • (2001) Mol Cell Biol , vol.21 , pp. 3192-3205
    • Woods, D.1    Cherwinski, H.2    Venetsanakos, E.3    Bhat, A.4    Gysin, S.5    Humbert, M.6    Bray, P.F.7    Saylor, V.L.8    McMahon, M.9
  • 110
    • 0028334894 scopus 로고
    • E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro
    • Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA. E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. J Cell Sci 1994;107:983-92.
    • (1994) J Cell Sci , vol.107 , pp. 983-992
    • Tang, A.1    Eller, M.S.2    Hara, M.3    Yaar, M.4    Hirohashi, S.5    Gilchrest, B.A.6
  • 112
    • 0031596340 scopus 로고    scopus 로고
    • Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model
    • Scott GA, Cassidy L. Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model. J Invest Dermatol 1998;111:243-50.
    • (1998) J Invest Dermatol , vol.111 , pp. 243-250
    • Scott, G.A.1    Cassidy, L.2
  • 113
    • 0035819040 scopus 로고    scopus 로고
    • Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development
    • Li G, Schaider H, Satyamoorthy K, Hanakawa Y, Hashimoto K, Herlyn M. Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene 2001;20:8125-35.
    • (2001) Oncogene , vol.20 , pp. 8125-8135
    • Li, G.1    Schaider, H.2    Satyamoorthy, K.3    Hanakawa, Y.4    Hashimoto, K.5    Herlyn, M.6
  • 114
    • 0033603018 scopus 로고    scopus 로고
    • MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis
    • Wilson D, Alessandrini A. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis. Cell Immunol 1999;194:67-77.
    • (1999) Cell Immunol , vol.194 , pp. 67-77
    • Wilson, D.1    Alessandrini, A.2
  • 115
    • 0032492538 scopus 로고    scopus 로고
    • Extracellular signal related kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis
    • Stadheim K, Kuvera G. Extracellular signal related kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis. Biochem Biophys Res Commun 1998;245:266-71.
    • (1998) Biochem Biophys Res Commun , vol.245 , pp. 266-271
    • Stadheim, K.1    Kuvera, G.2
  • 116
    • 0032949934 scopus 로고    scopus 로고
    • Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: Inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin
    • Persons DL, Yazlovitskaya EM, Cui W, Pelling JC. Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. Clin Cancer Res 1999;5:1007-14.
    • (1999) Clin Cancer Res , vol.5 , pp. 1007-1014
    • Persons, D.L.1    Yazlovitskaya, E.M.2    Cui, W.3    Pelling, J.C.4
  • 117
    • 0035313981 scopus 로고    scopus 로고
    • The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells
    • Mitsui H, Takuwa N, Maruyama T, Maekawa H, Hirayama M, Sawatari T, Hashimoto N, Takuwa Y, Kimura S. The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells. Int J Cancer 2001;92:55-62.
    • (2001) Int J Cancer , vol.92 , pp. 55-62
    • Mitsui, H.1    Takuwa, N.2    Maruyama, T.3    Maekawa, H.4    Hirayama, M.5    Sawatari, T.6    Hashimoto, N.7    Takuwa, Y.8    Kimura, S.9
  • 118
    • 0031059608 scopus 로고    scopus 로고
    • Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis
    • Jansen B, Schlagbauer-Wadl H, Eichler HG, Wolff K, van Elsas A, Schrier PI, Pehamberger H. Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis. Cancer Res 1997;57:362-5.
    • (1997) Cancer Res , vol.57 , pp. 362-365
    • Jansen, B.1    Schlagbauer-Wadl, H.2    Eichler, H.G.3    Wolff, K.4    Van Elsas, A.5    Schrier, P.I.6    Pehamberger, H.7
  • 119
    • 0034182666 scopus 로고    scopus 로고
    • The influence of the oncogene N-Ras on cell cycle delay in a human melanoma cell line with reduced radioresistance
    • Pomp J, Ouwerkerk IJ, Hoogstraten C, Wondergem J, Davelaar J, Leer JW, Schrier PI. The influence of the oncogene N-Ras on cell cycle delay in a human melanoma cell line with reduced radioresistance. Oncol Rep 2000;7:663-667.
    • (2000) Oncol Rep , vol.7 , pp. 663-667
    • Pomp, J.1    Ouwerkerk, I.J.2    Hoogstraten, C.3    Wondergem, J.4    Davelaar, J.5    Leer, J.W.6    Schrier, P.I.7


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