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Volumn 141, Issue 2, 2011, Pages

Early requirement of rac1 in a mouse model of pancreatic cancer

Author keywords

Cytoskeleton; Ductal Cell; Genetically Engineered Mice; Signaling

Indexed keywords

CERULETIDE; CRE RECOMBINASE; F ACTIN; K RAS PROTEIN; RAC1 PROTEIN;

EID: 80051540959     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.04.043     Document Type: Article
Times cited : (107)

References (45)
  • 3
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • O.J. De La, L.L. Emerson, and J.L. Goodman Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia Proc Natl Acad Sci U S A 105 2008 18907 18912
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18907-18912
    • De La, O.J.1    Emerson, L.L.2    Goodman, J.L.3
  • 8
    • 0031787342 scopus 로고    scopus 로고
    • Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice
    • DOI 10.1016/S0016-5085(98)70098-8
    • M. Wagner, H. Luhrs, and G. Kloppel Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice Gastroenterology 115 1998 1254 1262 (Pubitemid 28485618)
    • (1998) Gastroenterology , vol.115 , Issue.5 , pp. 1254-1262
    • Wagner, M.1    Luhrs, H.2    Kloppel, G.3    Adler, G.4    Schmid, R.M.5
  • 9
    • 77954636626 scopus 로고    scopus 로고
    • Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling
    • S.A. Blaine, K.C. Ray, and R. Anunobi Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling Development 137 2010 2289 2296
    • (2010) Development , vol.137 , pp. 2289-2296
    • Blaine, S.A.1    Ray, K.C.2    Anunobi, R.3
  • 10
    • 69249148349 scopus 로고    scopus 로고
    • Ras activity levels control the development of pancreatic diseases
    • 1082 e16
    • B. Ji, L. Tsou, and H. Wang Ras activity levels control the development of pancreatic diseases Gastroenterology 137 2009 1072 1082 1082 e16
    • (2009) Gastroenterology , vol.137 , pp. 1072-1082
    • Ji, B.1    Tsou, L.2    Wang, H.3
  • 11
    • 34548205213 scopus 로고    scopus 로고
    • G12D and Tgfa Results in Cystic Papillary Neoplasms Reminiscent of Human IPMN
    • DOI 10.1016/j.ccr.2007.08.002, PII S1535610807002310
    • J.T. Siveke, H. Einwachter, and B. Sipos Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN Cancer Cell 12 2007 266 279 (Pubitemid 47333415)
    • (2007) Cancer Cell , vol.12 , Issue.3 , pp. 266-279
    • Siveke, J.T.1    Einwachter, H.2    Sipos, B.3    Lubeseder-Martellato, C.4    Kloppel, G.5    Schmid, R.M.6
  • 13
    • 64049085356 scopus 로고    scopus 로고
    • Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
    • C. Carriere, A.L. Young, and J.R. Gunn Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras Biochem Biophys Res Commun 382 2009 561 565
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 561-565
    • Carriere, C.1    Young, A.L.2    Gunn, J.R.3
  • 14
    • 76649105065 scopus 로고    scopus 로고
    • Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    • J.P. Morris IV, D.A. Cano, and S. Sekine Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice J Clin Invest 120 2010 508 520
    • (2010) J Clin Invest , vol.120 , pp. 508-520
    • Morris, I.V.J.P.1    Cano, D.A.2    Sekine, S.3
  • 17
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • DOI 10.1038/nature01148
    • S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635 (Pubitemid 36764489)
    • (2002) Nature , vol.420 , Issue.6916 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 18
    • 0037900074 scopus 로고    scopus 로고
    • Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities
    • DOI 10.1074/jbc.M300341200
    • F. Guo, Y. Gao, and L. Wang p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities J Biol Chem 278 2003 14414 14419 (Pubitemid 36799994)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 14414-14419
    • Guo, F.1    Gao, Y.2    Wang, L.3    Zheng, Y.4
  • 20
    • 24044440401 scopus 로고    scopus 로고
    • Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion
    • Y. Bi, S.L. Page, and J.A. Williams Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion Am J Physiol Gastrointest Liver Physiol 289 2005 G561 G570
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Bi, Y.1    Page, S.L.2    Williams, J.A.3
  • 21
    • 0034978163 scopus 로고    scopus 로고
    • Regulation of c-myc expression by PDGF through Rho GTPases
    • DOI 10.1038/35078555
    • M. Chiariello, M.J. Marinissen, and J.S. Gutkind Regulation of c-myc expression by PDGF through Rho GTPases Nat Cell Biol 3 2001 580 586 (Pubitemid 32536855)
    • (2001) Nature Cell Biology , vol.3 , Issue.6 , pp. 580-586
    • Chiariello, M.1    Marinissen, M.J.2    Gutkind, J.S.3
  • 22
    • 0029101360 scopus 로고
    • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
    • M.F. Olson, A. Ashworth, and A. Hall An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1 Science 269 1995 1270 1272
    • (1995) Science , vol.269 , pp. 1270-1272
    • Olson, M.F.1    Ashworth, A.2    Hall, A.3
  • 23
    • 3142552767 scopus 로고    scopus 로고
    • Suppression of epithelial cell transformation and induction of actin dependent differentiation by dominant negative Rac1, but not Ras, Rho or Colo42
    • M.P. Quinlan Suppression of epithelial cell transformation and induction of actin dependent differentiation by dominant negative Rac1, but not Ras, Rho or Cdc42 Cancer Biol Ther 3 2004 65 70 (Pubitemid 41342421)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.1 , pp. 65-70
    • Quinlan, M.P.1
  • 24
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • R.G. Qiu, J. Chen, and D. Kirn An essential role for Rac in Ras transformation Nature 374 1995 457 459
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3
  • 25
    • 67649386478 scopus 로고    scopus 로고
    • Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer
    • M. Dokmanovic, D.S. Hirsch, and Y. Shen Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer Mol Cancer Ther 8 2009 1557 1569
    • (2009) Mol Cancer Ther , vol.8 , pp. 1557-1569
    • Dokmanovic, M.1    Hirsch, D.S.2    Shen, Y.3
  • 29
    • 77953480305 scopus 로고    scopus 로고
    • Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
    • Z. Wang, E. Pedersen, and A. Basse Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo Oncogene 29 2010 3362 3373
    • (2010) Oncogene , vol.29 , pp. 3362-3373
    • Wang, Z.1    Pedersen, E.2    Basse, A.3
  • 31
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain [1]
    • DOI 10.1038/5007
    • P. Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain Nat Genet 21 1999 70 71 (Pubitemid 29036285)
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 70-71
    • Soriano, P.1
  • 34
    • 38649140167 scopus 로고    scopus 로고
    • Notch signaling is required for exocrine regeneration after acute pancreatitis
    • J.T. Siveke, C. Lubeseder-Martellato, and M. Lee Notch signaling is required for exocrine regeneration after acute pancreatitis Gastroenterology 134 2008 544 555
    • (2008) Gastroenterology , vol.134 , pp. 544-555
    • Siveke, J.T.1    Lubeseder-Martellato, C.2    Lee, M.3
  • 35
    • 77955827414 scopus 로고    scopus 로고
    • Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    • P.K. Mazur, H. Einwachter, and M. Lee Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma Proc Natl Acad Sci U S A 107 2010 13438 13443
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13438-13443
    • Mazur, P.K.1    Einwachter, H.2    Lee, M.3
  • 36
    • 14244267058 scopus 로고    scopus 로고
    • Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro
    • DOI 10.1097/01.mpa.0000147086.15867.ab
    • N. Sphyris, C.D. Logsdon, and D.J. Harrison Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro Pancreas 30 2005 148 157 (Pubitemid 40289452)
    • (2005) Pancreas , vol.30 , Issue.2 , pp. 148-157
    • Sphyris, N.1    Logsdon, C.D.2    Harrison, D.J.3
  • 37
    • 0035065418 scopus 로고    scopus 로고
    • Effects of cytochalasin D and latrunculin B on mechanical properties of cells
    • T. Wakatsuki, B. Schwab, and N.C. Thompson Effects of cytochalasin D and latrunculin B on mechanical properties of cells J Cell Sci 114 2001 1025 1036 (Pubitemid 32266272)
    • (2001) Journal of Cell Science , vol.114 , Issue.5 , pp. 1025-1036
    • Wakatsuki, T.1    Schwab, B.2    Thompson, N.C.3    Elson, E.L.4
  • 38
    • 77957150824 scopus 로고    scopus 로고
    • KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
    • J.P. Morris IV, S.C. Wang, and M. Hebrok KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma Nat Rev Cancer 10 2010 683 695
    • (2010) Nat Rev Cancer , vol.10 , pp. 683-695
    • Morris, I.V.J.P.1    Wang, S.C.2    Hebrok, M.3
  • 39
    • 78049510823 scopus 로고    scopus 로고
    • Cancer treatment strategies targeting sphingolipid metabolism
    • B. Oskouian, and J.D. Saba Cancer treatment strategies targeting sphingolipid metabolism Adv Exp Med Biol 688 2010 185 205
    • (2010) Adv Exp Med Biol , vol.688 , pp. 185-205
    • Oskouian, B.1    Saba, J.D.2
  • 40
    • 77956459044 scopus 로고    scopus 로고
    • Rac and Rho GTPases in cancer cell motility control
    • M. Parri, and P. Chiarugi Rac and Rho GTPases in cancer cell motility control Cell Commun Signal 8 2010 23
    • (2010) Cell Commun Signal , vol.8 , pp. 23
    • Parri, M.1    Chiarugi, P.2
  • 41
    • 70350513347 scopus 로고    scopus 로고
    • Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras
    • S.Y. Gidekel Friedlander, G.C. Chu, and E.L. Snyder Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras Cancer Cell 16 2009 379 389
    • (2009) Cancer Cell , vol.16 , pp. 379-389
    • Gidekel Friedlander, S.Y.1    Chu, G.C.2    Snyder, E.L.3
  • 42
    • 51749122903 scopus 로고    scopus 로고
    • Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice
    • M.G. Binker, A.A. Binker-Cosen, and H.Y. Gaisano Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice Exp Physiol 93 2008 1091 1103
    • (2008) Exp Physiol , vol.93 , pp. 1091-1103
    • Binker, M.G.1    Binker-Cosen, A.A.2    Gaisano, H.Y.3
  • 43
    • 0033963376 scopus 로고    scopus 로고
    • Agonist-induced changes in cell shape during regulated secretion in rat pancreatic acini
    • DOI 10.1002/(SICI)1097-4652(200003)182:3<438::AID-JCP15>3.0.CO;2-N
    • R.R. Torgerson, and M.A. McNiven Agonist-induced changes in cell shape during regulated secretion in rat pancreatic acini J Cell Physiol 182 2000 438 447 (Pubitemid 30054378)
    • (2000) Journal of Cellular Physiology , vol.182 , Issue.3 , pp. 438-447
    • Torgerson, R.R.1    McNiven, M.A.2
  • 45
    • 77955827414 scopus 로고    scopus 로고
    • Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    • P.K. Mazur, H. Einwachter, and M. Lee Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma Proc Natl Acad Sci U S A 107 2010 13438 13443
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13438-13443
    • Mazur, P.K.1    Einwachter, H.2    Lee, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.