Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G 1 arrest and apoptosis

British Journal of Pharmacology

Volumn 155, Issue 5, 2008, Pages 641-654

  Jada, S R ^a,d   Matthews, C ^b   Saad, M S ^a   Hamzah, A S ^c   Lajis, N H ^a   Stevens, M F G ^b   Stanslas, J ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Andrographolide derivatives; Antitumour; Apoptosis; CDK 4; Cell cycle; G 1 arrest; NCI cell lines; v Src

Indexed keywords

3,19 (2 BROMOBENZYLIDENE)ANDROGRAPHOLIDE; 3,19 (3 BROMOBENZYLIDENE)ANDROGRAPHOLIDE; 3,19 (3 CHLORO 4 FLUOROBENZYLIDENE)ANDROGRAPHOLIDE; ANDROGRAPHOLIDE; BENZYLIDENE DERIVATIVE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 4; SRJ 09; SRJ 10; SRJ 23; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL DEATH; COLON CANCER; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME REPRESSION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZYLIDENE COMPOUNDS; BLOTTING, WESTERN; BREAST NEOPLASMS; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE 4; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G1 PHASE; HUMANS; MOLECULAR STRUCTURE;

EID: 54949147613     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.368     Document Type: Article

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