Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M

Angewandte Chemie - International Edition

Volumn 50, Issue 42, 2011, Pages 9838-9842

  Rusch, Marion ^a,b   Zimmermann, Tobias J ^a,b   Bürger, Marco ^a   Dekker, Frank J ^c   Görmer, Kristina ^a   Triola, Gemma ^a   Brockmeyer, Andreas ^a   Janning, Petra ^a   Böttcher, Thomas ^d   Sieber, Stephan A ^d   Vetter, Ingrid R ^a   Hedberg, Christian ^a   Waldmann, Herbert ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

acyl protein thioesterase; inhibition; proteomics; Ras proteins; signal transduction

Indexed keywords

ACTIVITY-BASED; CELLULAR TARGETS; PROTEOMIC PROFILING; PROTEOMICS; THIOESTERASES;

BIOSYNTHESIS; ENZYME INHIBITION; MOLECULAR BIOLOGY; SIGNAL TRANSDUCTION;

PROTEINS;

DRUG DERIVATIVE; ENZYME INHIBITOR; FATTY ACID SYNTHASE; PALMITOYL COENZYME A HYDROLASE; PALMOSTATIN B; PALMOSTATIN M; PROPIOLACTONE; PROTEOME; RAS PROTEIN; SULFONE; THIOESTERASE II; THIOL ESTER HYDROLASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HELA CELL; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; PALMITOYL-COA HYDROLASE; PROPIOLACTONE; PROTEOME; RAS PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIOLESTER HYDROLASES;

EID: 80053898528     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201102967     Document Type: Article

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