Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Anderson, Daniel J ^a   Durieux, Jenni K ^a   Song, Kyung ^a   Alvarado, Ryan ^a   Jackson, Peter K ^a   Hatzivassiliou, Georgia ^a   Ludlam, Mary J C ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (1 HYDROXYIMINO 5 INDANYL) 3 (4 PYRIDINYL) 1H PYRAZOL 1 YL]ETHANOL; AZD 628; C RAF KINASE; ENZYME INHIBITOR; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PLX 4720; RAF PROTEIN; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR;

ARTICLE; BIOENGINEERING; CELL LINE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; INTRACELLULAR SIGNALING; LIVE CELL MICROSCOPY; MICROSCOPY; MOLECULAR DYNAMICS; MONOTHERAPY; NEGATIVE FEEDBACK; PROTEIN BINDING; PROTEIN TRANSPORT; DRUG EFFECT; GENETICS; MUTATION; SIGNAL TRANSDUCTION;

CELL LINE; HUMANS; MAP KINASE SIGNALING SYSTEM; MUTATION; PROTEIN KINASE INHIBITORS;

EID: 79961146454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022607     Document Type: Article

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