A critical appraisal of the process of regulatory implementation of novel in vivo and in vitro methods for chemical hazard and risk assessment

Critical Reviews in Toxicology

Volumn 44, Issue 10, 2014, Pages 876-894

  Piersma, Aldert H ^a   Ezendam, Janine ^a   Luijten, Mirjam ^a   Muller, J J Andre ^a   Rorije, Emiel ^a   Van Der Ven, Leo T M ^a   Van Benthem, Jan ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Alternative method; Hazard assessment; In vitro assay; Regulatory implementation; Regulatory toxicology; Test batteries; Validation

Indexed keywords

CHEMICAL AGENT; DANGEROUS GOODS;

ANIMAL TESTING ALTERNATIVE; CARCINOGEN TESTING; CONSENSUS; DATA ANALYSIS; DEVELOPMENTAL TOXICITY; EMBRYONIC STEM CELL; EMBRYONIC STEM CELL TEST; EXPERIMENTAL TEST; HAZARD ASSESSMENT; HEALTH HAZARD; IN VITRO STUDY; IN VIVO STUDY; ISOLATED CHICKEN EYE TEST; KERATINOSENS ASSAY; LOCAL LYMPH NODE ASSAY; MUTAGEN TESTING; MUTATIONAL ANALYSIS; NONHUMAN; REGULATORY TOXICOLOGY; REVIEW; RISK ASSESSMENT; SKIN IRRITATION TEST; STANDARDIZATION; SYRIAN HAMSTER EMBRYO AND CELL TRANSFORMATION ASSAY; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; TOXICOLOGY; ANIMAL; DANGEROUS GOODS; DISEASE MODEL; HUMAN; PROCEDURES; TOXICITY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DISEASE MODELS, ANIMAL; HAZARDOUS SUBSTANCES; HUMANS; RISK ASSESSMENT; TOXICITY TESTS;

EID: 84910038158     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2014.940445     Document Type: Review

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