CB6F1-rasH2 mouse: Overview of available data

Toxicologic Pathology

Volumn 29, Issue SUPPL., 2001, Pages 90-108

  Usui, T ^a   Mutai, M ^a   Hisada, S ^a   Takoaka, M ^a   Soper, K A ^a   McCullough, B ^a   Alden, C ^a  

^a CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

26 Weeks; Alternatives; Bioassay; Carcinogenicity testing; CHa ras proto oncogene; Short term; Transgenic mouse

Indexed keywords

AMPICILLIN; CARCINOGEN; CHLORPROMAZINE; CLOFIBRATE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIELDRIN; DIETHYLSTILBESTROL; ESTRADIOL; HALOPERIDOL; MANNITOL; METHYLNITROSOUREA; ORCIPRENALINE; PEROXISOME PROLIFERATOR; PHENACETIN; PHENOBARBITAL; PHTHALIC ACID; PIRINIXIC ACID; RESERPINE; SULFAFURAZOLE; SULFAMETHIZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CARCINOGEN TESTING; CARCINOGENICITY; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENOTOXICITY; LABORATORY DIAGNOSIS; MALE; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTO ONCOGENE; REPRODUCIBILITY; TRANSGENIC MOUSE;

ACADEMIES AND INSTITUTES; ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENES, RAS; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MUTAGENS; NEOPLASMS, EXPERIMENTAL; REPRODUCIBILITY OF RESULTS; SOCIETIES, SCIENTIFIC;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0034752066     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262301753178500     Document Type: Conference Paper

References (21)

1. Chemically induced forestomach papillomas in transgenic mice carry mutant human c-ha-ras transgenes
2. Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice
3. Use of transgenic animals for carcinogenicity testing: Considerations and implications for risk assessment
4. Point mutations of the c-H-ras gene in spontaneous liver tumors of transgenic mice carrying the human c-H-ras gene
5. Hepatic drug metabolizing enzymes induced by chlorofibrate in rasH2 mice
6. Glomerulonephritis with fibrillary deposition in a transgenic mouse carrying the human prototype c-Ha-ras (rasH2 mouse)
7. Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study
8. Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model
9. Teratogenicity of cyclophosphamide metabolites: Phosphoramide mustard, acrolein, and 4-ketocyclophosphamide in rat embryos cultured in vitro
10. Pulmonary fibrosis caused by N-methyl-Nnitrosourethane inhibits lunch tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene
11. Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies
12. Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene
13. Current status and use of short/medium term models for carcinogenicity testing of pharmaceuticals-scientific perspective
14. A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice
15. Hepatic tumors induced by carbon tetrachloride in transgenic mice carrying a human c-H-ras proto-oncogene without mutations
16. Role of H-ras gene in chronic liver damage in mice by using transgenic mice carrying a human c-H-ras proto-oncogene without mutations
17. Susceptibility of experimental autoimmune hepatitis in transgenic mice overexpressing the c-H-ras gene
18. Susceptibility to urethane carcinogenesis of transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) and its modification by butylhydroxytoluene
19. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice
20. Validation of transgenic mice harboring the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing
21. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing