Induction of skin sensitization is augmented in Nrf2-deficient mice

Archives of Toxicology

Volumn 87, Issue 4, 2013, Pages 763-766

  Van Der Veen, Jochem W ^a,b   Gremmer, Eric R ^b   Vermeulen, Jolanda P ^b   Van Loveren, Henk ^a,b   Ezendam, Janine ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

In vivo; LLNA; Nrf2 deficient; Skin sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; IN VITRO STUDY; LOCAL LYMPH NODE ASSAY; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; SKIN SENSITIZATION; WILD TYPE;

ALLERGENS; ANIMALS; CELL COUNT; DERMATITIS, ALLERGIC CONTACT; DINITROCHLOROBENZENE; IRRITANTS; LOCAL LYMPH NODE ASSAY; LYMPH NODES; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; SKIN TESTS;

MUS;

EID: 84876666841     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0976-2     Document Type: Article

References (16)

1. Ade N, Leon F, Pallardy M, Peiffer JL, Kerdine-Romer S, Tissier MH, Bonnet PA, Fabre I, Ourlin JC (2009) HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. Toxicol Sci 107:451-460
2. Basketter D, Kolle SN, Schrage A, Honarvar N, Gamer AO, van Ravenzwaay B, Landsiedel R (2012) Experience with local lymph node assay performance standards using standard radioactivity and nonradioactive cell count measurements. J Appl Toxicol 32:590-596
3. Chan K, Lu R, Chang JC, Kan YW (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A 93:13943-13948
4. Emter R, Ellis G, Natsch A (2010) Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol Appl Pharmacol 245:281-290
5. Esser PR, Wolfle U, Durr C, von Loewenich FD, Schempp CM, Freudenberg MA, Jakob T, Martin SF (2012) Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation. PLoS ONE 7:e41340
6. Johansson H, Lindstedt M, Albrekt AS, Borrebaeck CA (2011) A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. BMC Genomics 12:399
7. Kim HJ, Barajas B, Wang M, Nel AE (2008) Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. J Allergy Clin Immunol 121:1255-1261
8. Kim J, Cha YN, Surh YJ (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res 690:12-23
9. Listopad J, Asadullah K, Sievers C, Ritter T, Meisel C, Sabat R, Docke WD (2007) Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells. Exp Dermatol 16:661-670
10. Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M (2011) Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy 66:1152-1163
11. Natsch A (2010) The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers-functional relevance and a hypothesis on innate reactions to skin sensitizers. Toxicol Sci 113:284-292
12. Python F, Goebel C, Aeby P (2009) Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol 239:273-283
13. Rushworth SA, MacEwan DJ, O'Connell MA (2008) Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol 181:6730-6737
14. Slob W (2002) Dose-response modelling of continuous endpoints. Toxicol Sci 66:298-312
15. van der Veen JW, Pronk TE, van Loveren H, Ezendam J (2012) Applicability of a keratinocyte gene signature to predict skin sensitizing potential. Toxicol In Vitro, Ahead of print
16. Vandebriel RJ, Pennings JL, Baken KA, Pronk TE, Boorsma A, Gottschalk R, Van Loveren H (2010) Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci 117:81-89