Xpa and Xpa/p53+/- knockout mice: Overview of available data

Toxicologic Pathology

Volumn 29, Issue SUPPL., 2001, Pages 117-127

  Van Kreijl, C F ^a   McAnulty, P A ^a   Beems, R B ^a   Vynckier, A ^a   Van Steeg, H ^a   Fransson Steen, R ^a   Alden, C L ^a   Forster, R ^a   Vandenberghe, J ^a   Van der Laan, J W ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Carcinogenicity testing; Carcinogens; DNA repair; Genotoxic; Nucleotide excision repair; Short term assay; Tumor suppressor gene; Xeroderma pigmentosum; XPA

Indexed keywords

4 CRESIDINE; AMPICILLIN; CARCINOGEN; CLOFIBRATE; CYCLOSPORIN A; DIETHYLSTILBESTROL; ESTRADIOL; HALOPERIDOL; MANNITOL; PHENACETIN; PHENOBARBITAL; PIRINIXIC ACID; PROTEIN P53; RESERPINE; SULFAMETHOXAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CARCINOGEN TESTING; CONFERENCE PAPER; CONTROLLED STUDY; DNA REPAIR; EXCISION REPAIR; FEMALE; GENOTOXICITY; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; TUMOR SUPPRESSOR GENE; XERODERMA PIGMENTOSUM;

ANIMALIA; RODENTIA;

EID: 0034749932     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262301753178528     Document Type: Conference Paper

References (26)

1. Too many rodent carcinogens: Mitogenesis increases mutagenesis
2. Chemically induced forestomach papillomas in transgenic mice carry mutant human c-H-ras transgenes
3. +/- mouse
4. Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice
5. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
6. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
7. The national toxicology program evaluation of genetically altered mice as predictive models for identifying carcinogens
8. Oncogenes and tumor suppressor genes in transgenic mouse models of neoplasia
9. Transgenic mice in carcinogenicity testing
10. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice
11. Cyclosporine induces cancer progression by a cell-autonomous mechanism
12. Tumor spectrum analysis in p53-mutant mice
13. -/- mice
14. V-H-ras transgene abrogates the iniation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid
15. Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies
16. The international life sciences institutes role in the evaluation of alternative methodologies for the assessment of carcinogenic risk
17. Most tumors in transgenic mice with human c-H-ras gene contained somatically activated transgenes
18. Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-H-ras gene
19. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models
20. Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens
21. Evaluation of the Eμ-pim-1 transgenic mouse model for short-term carcinogenicity testing
22. Transgenic mouse models for the identification of human carcinogens: A European perspective
23. Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
24. The effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice
25. Use of DNA repair deficient XPA transgenic mice in short-term carcinogenicity testing
26. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic trans-enic mice harboring a human prototype c-H-ras gene, than in control nontransgenic mice