Alternative models for carcinogenicity testing: Weight of evidence evaluations across models

Toxicologic Pathology

Volumn 29, Issue SUPPL., 2001, Pages 183-190

  Cohen, S M ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Chronic mouse bioassay; Chronic rat bioassay; Genotoxicity; Risk assessment; Transgenic mouse models

Indexed keywords

AMPICILLIN; CARCINOGEN; CHLOROFORM; CHLORPROMAZINE; CLOFIBRATE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIELDRIN; DIETHYLSTILBESTROL; ESTRADIOL; HALOPERIDOL; MANNITOL; MELPHALAN; METHAPYRILENE; ORCIPRENALINE; PHENACETIN; PHENOBARBITAL; PIRINIXIC ACID; RESERPINE; SULFAFURAZOLE; SULFAMETHOXAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BIOASSAY; CANCER MODEL; CARCINOGEN TESTING; CONFERENCE PAPER; GENOTOXICITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DISEASE MODELS, ANIMAL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTAGENS; NEOPLASMS, EXPERIMENTAL; RATS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0034750394     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262301753178609     Document Type: Conference Paper

References (24)

1. Rodent carcinogenicity bioassay: Past, present and future
2. Robustness in the strategy of scientific model building
3. +/- hemizygous knockout mouse: Studies with diethylstilbestrol
4. Cell proliferation and carcinogenesis
5. Infection, cell proliferation, and malignancy
6. Neonatal mouse assay for tumorigenicity: Alternative to the chronic rodent bioassay
7. Use of transgenic animals for carcinogenicity testing: Considerations and implications for risk assessment
8. Consensus report
9. Technical requirements for registration of pharmaceuticals for human use
10. Tumors of Sprague-Dawley rats induced by longterm feeding of phenacetin
11. Early detection of carcinogenic substances and modifiers in rats
12. Carcinogenicity of analgesics: Long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen)
13. Uroepithelial tumors of the renal pelvis associated with abuse of phenacetin-containing analgesics
14. Tumours of the urinary bladder and ureter associated with abuse of phenacetin-containing analgesics
15. The contribution of the mouse in hazard identification studies
16. 1
17. Workshop overview: Scientific and regulatory challenges for the reduction, refinement, and replacement of animals in toxicity testing
18. Laboratory animal tests and human cancer
19. Refinement of long-term toxicity and carcinogenesis studies
20. Bioassay design and MTD setting: Old methods and new approaches
21. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models
22. Genetically altered mouse models for identifying carcinogens
23. Transgenic mouse models for the identification of human carcinogens: A European perspective