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Volumn 20, Issue 38, 2014, Pages 13705-13717

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

Author keywords

6 phosphofructo 2 kinase fructose 2,6 bisphosphatase 3; 6 phosphofructo 2 kinase fructose 2,6 bisphosphatase 4; Gastric cancer; Hypoxia; Hypoxia inducible factor; Lung cancer; MKN45; NUGC3; Panc1; PST 1

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE FRUCTOSE 2,6 BISPHOSPHATASE 3; 6 PHOSPHOFRUCTO 2 KINASE FRUCTOSE 2,6 BISPHOSPHATASE 4; FRUCTOSE BISPHOSPHATASE; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; 6 PHOSPHOFRUCTO 2 KINASE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; PFKFB3 PROTEIN, HUMAN; PFKFB4 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84910015734     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i38.13705     Document Type: Review
Times cited : (66)

References (95)
  • 2
    • 66349115879 scopus 로고    scopus 로고
    • Glenohumeral rotation and scapular position adaptations after a single high school female sports season
    • PMID: 19478845
    • Thomas SJ, Swanik KA, Swanik C, Huxel KC. Glenohumeral rotation and scapular position adaptations after a single high school female sports season. J Athl Train 2009; 44: 230-237 [PMID: 19478845 DOI: 10.1002/jcb.22214]
    • (2009) J Athl Train , vol.44 , pp. 230-237
    • Thomas, S.J.1    Swanik, K.A.2    Swanik, C.3    Huxel, K.C.4
  • 3
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • PMID: 11181773
    • Höckel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001; 93: 266-276 [PMID: 11181773]
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 4
    • 84872859277 scopus 로고    scopus 로고
    • Lenticular cytoprotection. Part 1: The role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia
    • PMID: 23335846
    • Neelam S, Brooks MM, Cammarata PR. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol Vis 2013; 19: 1-15 [PMID: 23335846]
    • (2013) Mol Vis , vol.19 , pp. 1-15
    • Neelam, S.1    Brooks, M.M.2    Cammarata, P.R.3
  • 5
    • 73649127240 scopus 로고    scopus 로고
    • Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli
    • PMID: 19957303
    • Chiche J, Rouleau M, Gounon P, Brahimi-Horn MC, Pouysségur J, Mazure NM. Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli. J Cell Physiol 2010; 222: 648-657 [PMID: 19957303 DOI: 10.1002/jcp.21984]
    • (2010) J Cell Physiol , vol.222 , pp. 648-657
    • Chiche, J.1    Rouleau, M.2    Gounon, P.3    Brahimi-Horn, M.C.4    Pouysségur, J.5    Mazure, N.M.6
  • 7
    • 84872327077 scopus 로고    scopus 로고
    • c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α
    • PMID: 23237807
    • Chen C, Cai S, Wang G, Cao X, Yang X, Luo X, Feng Y, Hu J. c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α. Biochem Biophys Res Commun 2013; 430: 505-511 [PMID: 23237807 DOI: 10.1016/j.bbrc.2012.12.006]
    • (2013) Biochem Biophys Res Commun , vol.430 , pp. 505-511
    • Chen, C.1    Cai, S.2    Wang, G.3    Cao, X.4    Yang, X.5    Luo, X.6    Feng, Y.7    Hu, J.8
  • 8
    • 80051794576 scopus 로고    scopus 로고
    • Advances in pancreatic cancer
    • PMID: 21778878
    • Kim EJ, Simeone DM. Advances in pancreatic cancer. Curr Opin Gastroenterol 2011; 27: 460-466 [PMID: 21778878 DOI: 10.1097/MOG.0b013e328349e31f]
    • (2011) Curr Opin Gastroenterol , vol.27 , pp. 460-466
    • Kim, E.J.1    Simeone, D.M.2
  • 9
    • 0032053169 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
    • PMID: 9510527
    • Ratcliffe PJ, O'Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J Exp Biol 1998; 201: 1153-1162 [PMID: 9510527]
    • (1998) J Exp Biol , vol.201 , pp. 1153-1162
    • Ratcliffe, P.J.1    O'Rourke, J.F.2    Maxwell, P.H.3    Pugh, C.W.4
  • 10
    • 0036122242 scopus 로고    scopus 로고
    • Involvement of hypoxia-inducible factor 1 in human cancer
    • PMID: 11868612
    • Semenza GL. Involvement of hypoxia-inducible factor 1 in human cancer. Intern Med 2002; 41: 79-83 [PMID: 11868612]
    • (2002) Intern Med , vol.41 , pp. 79-83
    • Semenza, G.L.1
  • 12
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • PMID: 11943784
    • Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002; 277: 23111-23115 [PMID: 11943784 DOI: 10.1074/jbc.M202487200]
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 13
    • 0034649507 scopus 로고    scopus 로고
    • Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
    • PMID: 11175344
    • Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 2000; 19: 6297-6305 [PMID: 11175344]
    • (2000) Oncogene , vol.19 , pp. 6297-6305
    • Wykoff, C.C.1    Pugh, C.W.2    Maxwell, P.H.3    Harris, A.L.4    Ratcliffe, P.J.5
  • 14
    • 84872116039 scopus 로고    scopus 로고
    • δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF
    • PMID: 23220088
    • He Y, Kim H, Ryu T, Kang Y, Kim JA, Kim BH, Lee JH, Kang K, Lu Q, Kim K. δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF. FEBS Lett 2013; 587: 193-199 [PMID: 23220088 DOI: 10.1016/j.febslet.2012.11.024]
    • (2013) FEBS Lett , vol.587 , pp. 193-199
    • He, Y.1    Kim, H.2    Ryu, T.3    Kang, Y.4    Kim, J.A.5    Kim, B.H.6    Lee, J.H.7    Kang, K.8    Lu, Q.9    Kim, K.10
  • 16
    • 35448982216 scopus 로고    scopus 로고
    • Hypoxia, glucose metabolism and the Warburg's effect
    • PMID: 17661163
    • Bartrons R, Caro J. Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr 2007; 39: 223-229 [PMID: 17661163 DOI: 10.1007/s10863-007-9080-3]
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 223-229
    • Bartrons, R.1    Caro, J.2
  • 17
    • 67349131613 scopus 로고    scopus 로고
    • Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
    • PMID: 19454274
    • Yalcin A, Telang S, Clem B, Chesney J. Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. Exp Mol Pathol 2009; 86: 174-179 [PMID: 19454274 DOI: 10.1016/j.yexmp.2009.01.003]
    • (2009) Exp Mol Pathol , vol.86 , pp. 174-179
    • Yalcin, A.1    Telang, S.2    Clem, B.3    Chesney, J.4
  • 18
    • 79951699777 scopus 로고    scopus 로고
    • Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    • PMID: 21242296
    • Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 2011; 208: 313-326 [PMID: 21242296 DOI: 10.1084/jem.20101470]
    • (2011) J Exp Med , vol.208 , pp. 313-326
    • Wolf, A.1    Agnihotri, S.2    Micallef, J.3    Mukherjee, J.4    Sabha, N.5    Cairns, R.6    Hawkins, C.7    Guha, A.8
  • 20
    • 4344618856 scopus 로고    scopus 로고
    • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: Head-to-head with a bifunctional enzyme that controls glycolysis
    • PMID: 15170386
    • Rider MH, Bertrand L, Vertommen D, Michels PA, Rousseau GG, Hue L. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Biochem J 2004; 381: 561-579 [PMID: 15170386 DOI: 10.1042/BJ20040752]
    • (2004) Biochem J , vol.381 , pp. 561-579
    • Rider, M.H.1    Bertrand, L.2    Vertommen, D.3    Michels, P.A.4    Rousseau, G.G.5    Hue, L.6
  • 21
    • 0026076018 scopus 로고
    • Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase: Fructose-2,6-bisphosphatase
    • PMID: 1651918
    • Sakata J, Abe Y, Uyeda K. Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase. J Biol Chem 1991; 266: 15764-15770 [PMID: 1651918]
    • (1991) J Biol Chem , vol.266 , pp. 15764-15770
    • Sakata, J.1    Abe, Y.2    Uyeda, K.3
  • 22
    • 0032461972 scopus 로고    scopus 로고
    • Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase gene (PFKFB3)
    • PMID: 10072580
    • Manzano A, Rosa JL, Ventura F, Pérez JX, Nadal M, Estivill X, Ambrosio S, Gil J, Bartrons R. Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase gene (PFKFB3). Cytogenet Cell Genet 1998; 83: 214-217 [PMID: 10072580 DOI: 10.1159/000015181]
    • (1998) Cytogenet Cell Genet , vol.83 , pp. 214-217
    • Manzano, A.1    Rosa, J.L.2    Ventura, F.3    Pérez, J.X.4    Nadal, M.5    Estivill, X.6    Ambrosio, S.7    Gil, J.8    Bartrons, R.9
  • 24
    • 0242710750 scopus 로고    scopus 로고
    • Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo
    • PMID: 14623077
    • Minchenko O, Opentanova I, Caro J. Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett 2003; 554: 264-270 [PMID: 14623077 DOI: 10.1016/S0014-5793(03)01179-7]
    • (2003) FEBS Lett , vol.554 , pp. 264-270
    • Minchenko, O.1    Opentanova, I.2    Caro, J.3
  • 25
    • 4944228318 scopus 로고    scopus 로고
    • Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation
    • PMID: 15474002
    • Minchenko O, Opentanova I, Minchenko D, Ogura T, Esumi H. Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. FEBS Lett 2004; 576: 14-20 [PMID: 15474002 DOI: 10.1016/j.febslet.2004.08.053]
    • (2004) FEBS Lett , vol.576 , pp. 14-20
    • Minchenko, O.1    Opentanova, I.2    Minchenko, D.3    Ogura, T.4    Esumi, H.5
  • 26
    • 33747505788 scopus 로고    scopus 로고
    • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis
    • PMID: 16912547
    • Chesney J . 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis. Curr Opin Clin Nutr Metab Care 2006; 9: 535-539 [PMID: 16912547]
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , pp. 535-539
    • Chesney, J.1
  • 27
    • 0037155247 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
    • PMID: 11744734
    • Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 2002; 277: 6183-6187 [PMID: 11744734]
    • (2002) J Biol Chem , vol.277 , pp. 6183-6187
    • Minchenko, A.1    Leshchinsky, I.2    Opentanova, I.3    Sang, N.4    Srinivas, V.5    Armstead, V.6    Caro, J.7
  • 28
    • 0033057367 scopus 로고    scopus 로고
    • An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect
    • PMID: 10077634
    • Chesney J, Mitchell R, Benigni F, Bacher M, Spiegel L, Al-Abed Y, Han JH, Metz C, Bucala R. An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. Proc Natl Acad Sci USA 1999; 96: 3047-3052 [PMID: 10077634]
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3047-3052
    • Chesney, J.1    Mitchell, R.2    Benigni, F.3    Bacher, M.4    Spiegel, L.5    Al-Abed, Y.6    Han, J.H.7    Metz, C.8    Bucala, R.9
  • 29
    • 0037108709 scopus 로고    scopus 로고
    • High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
    • PMID: 12384552
    • Atsumi T, Chesney J, Metz C, Leng L, Donnelly S, Makita Z, Mitchell R, Bucala R. High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res 2002; 62: 5881-5887 [PMID: 12384552]
    • (2002) Cancer Res , vol.62 , pp. 5881-5887
    • Atsumi, T.1    Chesney, J.2    Metz, C.3    Leng, L.4    Donnelly, S.5    Makita, Z.6    Mitchell, R.7    Bucala, R.8
  • 31
    • 31544463794 scopus 로고    scopus 로고
    • Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines
    • PMID: 16025159
    • Minchenko OH, Opentanova IL, Ogura T, Minchenko DO, Komisarenko SV, Caro J, Esumi H. Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines. Acta Biochim Pol 2005; 52: 881-888 [PMID: 16025159]
    • (2005) Acta Biochim Pol , vol.52 , pp. 881-888
    • Minchenko, O.H.1    Opentanova, I.L.2    Ogura, T.3    Minchenko, D.O.4    Komisarenko, S.V.5    Caro, J.6    Esumi, H.7
  • 32
    • 33846131233 scopus 로고    scopus 로고
    • Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers
    • PMID: 17143338
    • Bobarykina AY, Minchenko DO, Opentanova IL, Moenner M, Caro J, Esumi H, Minchenko OH. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. Acta Biochim Pol 2006; 53: 789-799 [PMID: 17143338]
    • (2006) Acta Biochim Pol , vol.53 , pp. 789-799
    • Bobarykina, A.Y.1    Minchenko, D.O.2    Opentanova, I.L.3    Moenner, M.4    Caro, J.5    Esumi, H.6    Minchenko, O.H.7
  • 33
    • 25444464113 scopus 로고    scopus 로고
    • Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors
    • PMID: 15925437
    • Minchenko OH, Ochiai A, Opentanova IL, Ogura T, Minchenko DO, Caro J, Komisarenko SV, Esumi H. Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors. Biochimie 2005; 87: 1005-1010 [PMID: 15925437 DOI: 10.1016/j/biochip.2005.04.007]
    • (2005) Biochimie , vol.87 , pp. 1005-1010
    • Minchenko, O.H.1    Ochiai, A.2    Opentanova, I.L.3    Ogura, T.4    Minchenko, D.O.5    Caro, J.6    Komisarenko, S.V.7    Esumi, H.8
  • 35
    • 38049077430 scopus 로고    scopus 로고
    • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is upregulated in high-grade astrocytomas
    • PMID: 17805487
    • Kessler R, Bleichert F, Warnke JP, Eschrich K. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is upregulated in high-grade astrocytomas. J Neurooncol 2008; 86: 257-264 [PMID: 17805487 DOI: 10.1007/s11060-007-9471-7]
    • (2008) J Neurooncol , vol.86 , pp. 257-264
    • Kessler, R.1    Bleichert, F.2    Warnke, J.P.3    Eschrich, K.4
  • 36
    • 9144236903 scopus 로고    scopus 로고
    • Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
    • PMID: 15598882
    • Fukasawa M, Tsuchiya T, Takayama E, Shinomiya N, Uyeda K, Sakakibara R, Seki S. Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. J Biochem 2004; 136: 273-277 [PMID: 15598882 DOI: 10.1093/jb/mvhl37]
    • (2004) J Biochem , vol.136 , pp. 273-277
    • Fukasawa, M.1    Tsuchiya, T.2    Takayama, E.3    Shinomiya, N.4    Uyeda, K.5    Sakakibara, R.6    Seki, S.7
  • 37
    • 19944399717 scopus 로고    scopus 로고
    • 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia
    • PMID: 15466858
    • Obach M, Navarro-Sabaté A, Caro J, Kong X, Duran J, Gómez M, Perales JC, Ventura F, Rosa JL, Bartrons R. 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. J Biol Chem 2004; 279: 53562-53570 [PMID: 15466858 DOI: 10.1074/jbc.M406096200]
    • (2004) J Biol Chem , vol.279 , pp. 53562-53570
    • Obach, M.1    Navarro-Sabaté, A.2    Caro, J.3    Kong, X.4    Duran, J.5    Gómez, M.6    Perales, J.C.7    Ventura, F.8    Rosa, J.L.9    Bartrons, R.10
  • 38
    • 0037163076 scopus 로고    scopus 로고
    • The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
    • PMID: 12065600
    • Marsin AS, Bouzin C, Bertrand L, Hue L. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem 2002; 277: 30778-30783 [PMID: 12065600 DOI: 10.1074/jbc.M205213200]
    • (2002) J Biol Chem , vol.277 , pp. 30778-30783
    • Marsin, A.S.1    Bouzin, C.2    Bertrand, L.3    Hue, L.4
  • 40
    • 23844517036 scopus 로고    scopus 로고
    • Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer
    • PMID: 16115917
    • Bando H, Atsumi T, Nishio T, Niwa H, Mishima S, Shimizu C, Yoshioka N, Bucala R, Koike T. Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer. Clin Cancer Res 2005; 11: 5784-5792 [PMID: 16115917 DOI: 10.1158/1078-0432.CCR-05-0149]
    • (2005) Clin Cancer Res , vol.11 , pp. 5784-5792
    • Bando, H.1    Atsumi, T.2    Nishio, T.3    Niwa, H.4    Mishima, S.5    Shimizu, C.6    Yoshioka, N.7    Bucala, R.8    Koike, T.9
  • 42
    • 76249114497 scopus 로고    scopus 로고
    • E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation
    • PMID: 20080744
    • Almeida A, Bolaños JP, Moncada S. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci USA 2010; 107: 738-741 [PMID: 20080744 DOI: 10.1073/pnas.0913668107]
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 738-741
    • Almeida, A.1    Bolaños, J.P.2    Moncada, S.3
  • 43
    • 84890383811 scopus 로고    scopus 로고
    • Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells
    • PMID: 24169697
    • Cordero-Espinoza L, Hagen T. Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells. J Biol Chem 2013; 288: 36020-36028 [PMID: 24169697 DOI: 10.1074/jbc.M113.510289]
    • (2013) J Biol Chem , vol.288 , pp. 36020-36028
    • Cordero-Espinoza, L.1    Hagen, T.2
  • 44
    • 79955076736 scopus 로고    scopus 로고
    • Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle
    • PMID: 21402913
    • Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH, Moncada S. Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle. Proc Natl Acad Sci USA 2011; 108: 5278-5283 [PMID: 21402913 DOI: 10.1073/pnas.1102247108]
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5278-5283
    • Tudzarova, S.1    Colombo, S.L.2    Stoeber, K.3    Carcamo, S.4    Williams, G.H.5    Moncada, S.6
  • 45
    • 79551469518 scopus 로고    scopus 로고
    • Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells
    • PMID: 20958264
    • Moon JS, Jin WJ, Kwak JH, Kim HJ, Yun MJ, Kim JW, Park SW, Kim KS. Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells. Biochem J 2011; 433: 225-233 [PMID: 20958264 DOI: 10.1042/BJ20101104]
    • (2011) Biochem J , vol.433 , pp. 225-233
    • Moon, J.S.1    Jin, W.J.2    Kwak, J.H.3    Kim, H.J.4    Yun, M.J.5    Kim, J.W.6    Park, S.W.7    Kim, K.S.8
  • 47
    • 84879716958 scopus 로고    scopus 로고
    • The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration
    • PMID: 23840896
    • Kumar P, Sharoyko VV, Spégel P, Gullberg U, Mulder H, Olsson I, Ajore R. The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration. PLoS One 2013; 8: e68502 [PMID: 23840896 DOI: 10.1371/journal.pone.0068502]
    • (2013) PLoS One , vol.8 , pp. e68502
    • Kumar, P.1    Sharoyko, V.V.2    Spégel, P.3    Gullberg, U.4    Mulder, H.5    Olsson, I.6    Ajore, R.7
  • 48
    • 70449707222 scopus 로고    scopus 로고
    • The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impedes the growth of U87 glioblastoma cells
    • PMID: 19490427
    • Zscharnack K, Kessler R, Bleichert F, Warnke JP, Eschrich K. The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impedes the growth of U87 glioblastoma cells. Neuropathol Appl Neurobiol 2009; 35: 566-578 [PMID: 19490427 DOI: 10.1111/j.1365-2990.2009.01027.x]
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 566-578
    • Zscharnack, K.1    Kessler, R.2    Bleichert, F.3    Warnke, J.P.4    Eschrich, K.5
  • 49
    • 33644677951 scopus 로고    scopus 로고
    • Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation
    • PMID: 16306349
    • Atsumi T, Nishio T, Niwa H, Takeuchi J, Bando H, Shimizu C, Yoshioka N, Bucala R, Koike T. Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation. Diabetes 2005; 54: 3349-3357 [PMID: 16306349 DOI: 10.2337/diabetes.54.12.3349]
    • (2005) Diabetes , vol.54 , pp. 3349-3357
    • Atsumi, T.1    Nishio, T.2    Niwa, H.3    Takeuchi, J.4    Bando, H.5    Shimizu, C.6    Yoshioka, N.7    Bucala, R.8    Koike, T.9
  • 52
    • 84864767268 scopus 로고    scopus 로고
    • Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
    • PMID: 22576210
    • Ros S, Santos CR, Moco S, Baenke F, Kelly G, Howell M, Zamboni N, Schulze A. Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov 2012; 2: 328-343 [PMID: 22576210 DOI: 10.1158/2159-8290.CD-11-0234]
    • (2012) Cancer Discov , vol.2 , pp. 328-343
    • Ros, S.1    Santos, C.R.2    Moco, S.3    Baenke, F.4    Kelly, G.5    Howell, M.6    Zamboni, N.7    Schulze, A.8
  • 53
    • 80051665521 scopus 로고    scopus 로고
    • Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway
    • PMID: 21640852
    • Jeon YK, Yoo DR, Jang YH, Jang SY, Nam MJ. Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway. Biochim Biophys Acta 2011; 1814: 1340-1348 [PMID: 21640852 DOI: 10.1016/j.bbapap.2011.05.015]
    • (2011) Biochim Biophys Acta , vol.1814 , pp. 1340-1348
    • Jeon, Y.K.1    Yoo, D.R.2    Jang, Y.H.3    Jang, S.Y.4    Nam, M.J.5
  • 55
    • 84870569070 scopus 로고    scopus 로고
    • PFKFB4 as a prognostic marker in non-muscle-invasive bladder cancer
    • PMID: 21396842
    • Yun SJ, Jo SW, Ha YS, Lee OJ, Kim WT, Kim YJ, Lee SC, Kim WJ. PFKFB4 as a prognostic marker in non-muscle-invasive bladder cancer. Urol Oncol 2012; 30: 893-899 [PMID: 21396842 DOI: 10.1016/j.urolonc.2010.08.018]
    • (2012) Urol Oncol , vol.30 , pp. 893-899
    • Yun, S.J.1    Jo, S.W.2    Ha, Y.S.3    Lee, O.J.4    Kim, W.T.5    Kim, Y.J.6    Lee, S.C.7    Kim, W.J.8
  • 56
    • 84866235983 scopus 로고    scopus 로고
    • Cancer cell metabolism: There is no ROS for the weary
    • PMID: 22576206
    • Dang CV. Cancer cell metabolism: there is no ROS for the weary. Cancer Discov 2012; 2: 304-307 [PMID: 22576206 DOI: 10.1158/2159-8290.CD-12-0069]
    • (2012) Cancer Discov , vol.2 , pp. 304-307
    • Dang, C.V.1
  • 57
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • PMID: 22549953
    • Dang CV. Links between metabolism and cancer. Genes Dev 2012; 26: 877-890 [PMID: 22549953 DOI: 10.1101/gad.189365.112]
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 58
    • 29244445515 scopus 로고    scopus 로고
    • Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: Expression and hypoxic regulation
    • PMID: 16311927
    • Minchenko OH, Ogura T, Opentanova IL, Minchenko DO, Esumi H. Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation. Mol Cell Biochem 2005; 280: 227-234 [PMID: 16311927]
    • (2005) Mol Cell Biochem , vol.280 , pp. 227-234
    • Minchenko, O.H.1    Ogura, T.2    Opentanova, I.L.3    Minchenko, D.O.4    Esumi, H.5
  • 61
    • 84877864512 scopus 로고    scopus 로고
    • Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration
    • PMID: 23377827
    • Liu Z, Jia X, Duan Y, Xiao H, Sundqvist KG, Permert J, Wang F. Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration. Cancer Biol Ther 2013; 14: 428-435 [PMID: 23377827 DOI: 10.4161/cbt.23786]
    • (2013) Cancer Biol Ther , vol.14 , pp. 428-435
    • Liu, Z.1    Jia, X.2    Duan, Y.3    Xiao, H.4    Sundqvist, K.G.5    Permert, J.6    Wang, F.7
  • 63
    • 0031969042 scopus 로고    scopus 로고
    • Hypoxia and the regulation of gene expression
    • PMID: 9575495
    • Gleadle JM, Ratcliffe PJ. Hypoxia and the regulation of gene expression. Mol Med Today 1998; 4: 122-129 [PMID: 9575495]
    • (1998) Mol Med Today , vol.4 , pp. 122-129
    • Gleadle, J.M.1    Ratcliffe, P.J.2
  • 64
    • 0033936370 scopus 로고    scopus 로고
    • Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: Role of hypoxia responsive element
    • PMID: 10939628
    • Minchenko A, Caro J. Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: role of hypoxia responsive element. Mol Cell Biochem 2000; 208: 53-62 [PMID: 10939628]
    • (2000) Mol Cell Biochem , vol.208 , pp. 53-62
    • Minchenko, A.1    Caro, J.2
  • 66
    • 2442544693 scopus 로고    scopus 로고
    • Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: Implication of natural antisense HIF-1alpha
    • PMID: 14744852
    • Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 2004; 279: 14871-14878 [PMID: 14744852 DOI: 10.1074/jbc.M400461200]
    • (2004) J Biol Chem , vol.279 , pp. 14871-14878
    • Uchida, T.1    Rossignol, F.2    Matthay, M.A.3    Mounier, R.4    Couette, S.5    Clottes, E.6    Clerici, C.7
  • 67
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • PMID: 11823643
    • Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002; 295: 858-861 [PMID: 11823643]
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 72
    • 36348943088 scopus 로고    scopus 로고
    • Integrated endoplasmic reticulum stress responses in cancer
    • PMID: 18006802
    • Moenner M, Pluquet O, Bouchecareilh M, Chevet E. Integrated endoplasmic reticulum stress responses in cancer. Cancer Res 2007; 67: 10631-10634 [PMID: 18006802 DOI: 10.1158/0008-5472.CAN-07-1705]
    • (2007) Cancer Res , vol.67 , pp. 10631-10634
    • Moenner, M.1    Pluquet, O.2    Bouchecareilh, M.3    Chevet, E.4
  • 75
    • 84863740827 scopus 로고    scopus 로고
    • The impact of the unfolded protein response on human disease
    • PMID: 22733998
    • Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. J Cell Biol 2012; 197: 857-867 [PMID: 22733998 DOI: 10.1083/jcb.201110131]
    • (2012) J Cell Biol , vol.197 , pp. 857-867
    • Wang, S.1    Kaufman, R.J.2
  • 76
    • 33646167400 scopus 로고    scopus 로고
    • ER stress, hypoxia tolerance and tumor progression
    • PMID: 16472113
    • Koumenis C. ER stress, hypoxia tolerance and tumor progression. Curr Mol Med 2006; 6: 55-69 [PMID: 16472113 DOI: 10.2174/156652406775574604]
    • (2006) Curr Mol Med , vol.6 , pp. 55-69
    • Koumenis, C.1
  • 77
    • 84877134387 scopus 로고    scopus 로고
    • Expression of hexokinase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase genes in ERN1 knockdown glioma U87 cells: Effect of hypoxia and glutamine or glucose deprivation
    • Minchenko DO, Marunych RY, Khomenko EV, Bakalets TV, Minchenko OH. Expression of hexokinase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase genes in ERN1 knockdown glioma U87 cells: effect of hypoxia and glutamine or glucose deprivation. Studia Biologica 2011; 5: 5-18
    • (2011) Studia Biologica , vol.5 , pp. 5-18
    • Minchenko, D.O.1    Marunych, R.Y.2    Khomenko, E.V.3    Bakalets, T.V.4    Minchenko, O.H.5
  • 79
    • 84991674048 scopus 로고    scopus 로고
    • The effect of hypoxia and ischemic condition on the expression of VEGF genes in glioma U87 cells is dependent from ERN1 knockdown
    • Minchenko DO, Kubajchuk KI, Ratushna OO, Komisarenko SV, Minchenko OH. The effect of hypoxia and ischemic condition on the expression of VEGF genes in glioma U87 cells is dependent from ERN1 knockdown. Adv Biol Chem 2011; 2: 198-206 [DOI: 10.4236/abc.2012.22024]
    • (2011) Adv Biol Chem , vol.2 , pp. 198-206
    • Minchenko, D.O.1    Kubajchuk, K.I.2    Ratushna, O.O.3    Komisarenko, S.V.4    Minchenko, O.H.5
  • 81
    • 84888138948 scopus 로고    scopus 로고
    • Control of vessel sprouting by genetic and metabolic determinants
    • PMID: 24075830
    • Eelen G, Cruys B, Welti J, De Bock K, Carmeliet P. Control of vessel sprouting by genetic and metabolic determinants. Trends Endocrinol Metab 2013; 24: 589-596 [PMID: 24075830 DOI: 10.1016/j.tem.2013.08.006]
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 589-596
    • Eelen, G.1    Cruys, B.2    Welti, J.3    De Bock, K.4    Carmeliet, P.5
  • 82
    • 84883856976 scopus 로고    scopus 로고
    • Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells
    • PMID: 23726431
    • Mace TA, Collins AL, Wojcik SE, Croce CM, Lesinski GB, Bloomston M. Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells. J Surg Res 2013; 184: 855-860 [PMID: 23726431 DOI: 10.1016/j.jss.2013.04.061]
    • (2013) J Surg Res , vol.184 , pp. 855-860
    • Mace, T.A.1    Collins, A.L.2    Wojcik, S.E.3    Croce, C.M.4    Lesinski, G.B.5    Bloomston, M.6
  • 83
    • 84884902758 scopus 로고    scopus 로고
    • MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors
    • PMID: 23108411
    • Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S, Yonezawa S. MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Oncogene 2013; 32: 4614-4621 [PMID: 23108411 DOI: 10.1038/onc.2012.478]
    • (2013) Oncogene , vol.32 , pp. 4614-4621
    • Kitamoto, S.1    Yokoyama, S.2    Higashi, M.3    Yamada, N.4    Takao, S.5    Yonezawa, S.6
  • 84
    • 84878969160 scopus 로고    scopus 로고
    • Evaluating tumor angiogenesis
    • PMID: 23359165
    • Uh MK, Kandel J, Kitajewski J. Evaluating tumor angiogenesis. Methods Mol Biol 2013; 980: 341-351 [PMID: 23359165 DOI: 10.1007/978-1-62703-287-2-20]
    • (2013) Methods Mol Biol , vol.980 , pp. 341-351
    • Uh, M.K.1    Kandel, J.2    Kitajewski, J.3
  • 85
    • 84873522077 scopus 로고    scopus 로고
    • CHC promotes tumor growth and angiogenesis through regulation of HIF-α and VEGF signaling
    • PMID: 23228632
    • Tung KH, Lin CW, Kuo CC, Li LT, Kuo YH, Lin CW, Wu HC. CHC promotes tumor growth and angiogenesis through regulation of HIF-α and VEGF signaling. Cancer Lett 2013; 331: 58-67 [PMID: 23228632 DOI: 10.1016/j.canlet.2012.12.001]
    • (2013) Cancer Lett , vol.331 , pp. 58-67
    • Tung, K.H.1    Lin, C.W.2    Kuo, C.C.3    Li, L.T.4    Kuo, Y.H.5    Lin, C.W.6    Wu, H.C.7
  • 86
    • 84869464637 scopus 로고    scopus 로고
    • The real face of HIF1α in the tumor process
    • PMID: 22987151
    • Kappler M, Taubert H, Schubert J, Vordermark D, Eckert AW. The real face of HIF1α in the tumor process. Cell Cycle 2012; 11: 3932-3936 [PMID: 22987151 DOI: 10.4161/cc.21854]
    • (2012) Cell Cycle , vol.11 , pp. 3932-3936
    • Kappler, M.1    Taubert, H.2    Schubert, J.3    Vordermark, D.4    Eckert, A.W.5
  • 87
    • 84878408912 scopus 로고    scopus 로고
    • Adapting glycolysis to cancer cell proliferation: The MAPK pathway focuses on PFKFB3
    • PMID: 23725459
    • Bolaños JP. Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3. Biochem J 2013; 452: e7-e9 [PMID: 23725459 DOI: 10.1042/BJ20130560]
    • (2013) Biochem J , vol.452 , pp. e7-e9
    • Bolaños, J.P.1
  • 89
    • 70349168446 scopus 로고    scopus 로고
    • Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
    • PMID: 19782034
    • Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 2009; 35: 856-867 [PMID: 19782034 DOI: 10.1016/j.molcel.2009.09.006]
    • (2009) Mol Cell , vol.35 , pp. 856-867
    • Huang, X.1    Ding, L.2    Bennewith, K.L.3    Tong, R.T.4    Welford, S.M.5    Ang, K.K.6    Story, M.7    Le, Q.T.8    Giaccia, A.J.9
  • 90
    • 84885001174 scopus 로고    scopus 로고
    • HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression
    • PMID: 24008827
    • Shi CY, Fan Y, Liu B, Lou WH. HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression. Cell Physiol Biochem 2013; 32: 561-568 [PMID: 24008827 DOI: 10.1159/000354460]
    • (2013) Cell Physiol Biochem , vol.32 , pp. 561-568
    • Shi, C.Y.1    Fan, Y.2    Liu, B.3    Lou, W.H.4
  • 92
    • 80052988662 scopus 로고    scopus 로고
    • Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effect
    • PMID: 21957443
    • Seo M, Kim JD, Neau D, Sehgal I, Lee YH. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 2011; 6: e24179 [PMID: 21957443 DOI: 10.1371/journal.pone.0024179]
    • (2011) PLoS One , vol.6 , pp. e24179
    • Seo, M.1    Kim, J.D.2    Neau, D.3    Sehgal, I.4    Lee, Y.H.5
  • 94
    • 84894477280 scopus 로고    scopus 로고
    • The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy
    • PMID: 24351650
    • Yang Z, Goronzy JJ, Weyand CM. The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy. Autophagy 2014; 10: 382-383 [PMID: 24351650]
    • (2014) Autophagy , vol.10 , pp. 382-383
    • Yang, Z.1    Goronzy, J.J.2    Weyand, C.M.3
  • 95
    • 84909988207 scopus 로고    scopus 로고
    • Dominant-negative constructs of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4: Effect on the expression of endogenous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA
    • Minchenko DO, Bobarykina AY, Ratushna OO, Marunych RY, Tsuchihara K, Moenner M, Caro J, Esumi H, Minchenko OH. Dominant-negative constructs of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4: effect on the expression of endogenous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA. Biotechnology 2008; 1: 49-56
    • (2008) Biotechnology , vol.1 , pp. 49-56
    • Minchenko, D.O.1    Bobarykina, A.Y.2    Ratushna, O.O.3    Marunych, R.Y.4    Tsuchihara, K.5    Moenner, M.6    Caro, J.7    Esumi, H.8    Minchenko, O.H.9


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