Excess glucose induces hypoxia-inducible factor-1a in pancreatic cancer cells and stimulates glucose metabolism and cell migration

Cancer Biology and Therapy

Volumn 14, Issue 5, 2013, Pages 428-435

  Liu, Zhiwen ^a   Jia, Xiaohui ^a   Duan, Yijie ^b   Xiao, Huijie ^c   Sundqvist, Karl Gösta ^a   Permert, Johan ^a   Wang, Feng ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

Cell migration; Glucose; Glycolysis; Hexokinase II; Hypoxia inducible factor 1; Pancreatic cancer; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; FUMARIC ACID; GLUCOSE; HEXOKINASE; HEXOKINASE ISOENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; MESSENGER RNA; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL HYPOXIA; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MITOCHONDRION; PANCREAS CANCER; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE;

CELL MIGRATION; GLUCOSE; GLYCOLYSIS; HEXOKINASE-II; HYPOXIA-INDUCIBLE FACTOR-1; PANCREATIC CANCER; REACTIVE OXYGEN SPECIES;

ADENOSINE TRIPHOSPHATE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PANCREATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84877864512     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.23786     Document Type: Article

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