Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR)-dependent manner

Journal of Biological Chemistry

Volumn 289, Issue 45, 2014, Pages 31136-31149

  Louw du Toit, Renate ^a   Hapgood, Janet P ^b   Africander, Donita ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONES; TRANSCRIPTION; VOLATILE FATTY ACIDS;

CHROMATIN IMMUNOPRECIPITATION; DOSE-DEPENDENT MANNER; ENHANCER-BINDING PROTEINS; GLUCOCORTICOID RECEPTOR; HORMONE REPLACEMENT THERAPY; MEDROXYPROGESTERONE; MOLECULAR MECHANISM; NUCLEAR FACTOR KAPPAB;

CELL CULTURE;

CCAAT ENHANCER BINDING PROTEIN BETA; GESTAGEN; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; PROGESTERONE; SMALL INTERFERING RNA; STAT3 PROTEIN; CEBPB PROTEIN, HUMAN; CONTRACEPTIVE AGENT; IL10 PROTEIN, HUMAN; IL12A PROTEIN, HUMAN; IL12B PROTEIN, HUMAN; INTERLEUKIN 12P35; INTERLEUKIN 12P40; STAT3 PROTEIN, HUMAN;

ARTICLE; CELL CULTURE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DOWN REGULATION; DRUG MECHANISM; ECTOCERVICAL EPITHELIAL CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMALE GENITAL TRACT INFLAMMATION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC REGULATION; GENETIC TRANSCRIPTION; GENOMICS; HUMAN; HUMAN CELL; IL 10 GENE; IL 12P35 GENE; IL 12P40 GENE; IN VITRO STUDY; PROMOTER REGION; UPREGULATION; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; UTERINE CERVIX;

CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE; CERVIX UTERI; CONTRACEPTIVE AGENTS, FEMALE; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-12 SUBUNIT P40; MEDROXYPROGESTERONE ACETATE; NF-KAPPA B; PROGESTINS; RECEPTORS, GLUCOCORTICOID; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR;

EID: 84909957815     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.587311     Document Type: Article

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