Hormonal Contraception and HIV-1 Transmission

American Journal of Reproductive Immunology

Volumn 65, Issue 3, 2011, Pages 302-307

  Blish, Catherine A ^a,b   Baeten, Jared M ^b,c  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Acquisition; DMPA; HIV 1; Hormonal contraceptives; Oral contraceptives; Transmission

Indexed keywords

CONTRACEPTIVE AGENT; VIRUS DNA;

CONDOM; FEMALE GENITAL SYSTEM; HORMONAL CONTRACEPTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; LABORATORY TEST; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRUS TRANSMISSION;

CERVIX UTERI; CONDOMS; CONTRACEPTIVES, ORAL, HORMONAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; RISK FACTORS; VAGINA;

EID: 79551647890     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2010.00930.x     Document Type: Review

References (45)

1. Joint United Nations Programme on HIV/AIDS. Report on the global AIDS epidemic 2009. Available at: asp. Accessed 16 June 2010.
2. Baeten JM, Lavreys L, Overbaugh J: The influence of hormonal contraceptive use on HIV-1 transmission and disease progression. Clin Infect Dis 2007; 45:360-369.
3. Stringer E, Antonsen E: Hormonal contraception and HIV disease progression. Clin Infect Dis 2008; 47:945-951.
4. Stringer EM, Giganti M, Carter RJ, El-Sadr W, Abrams EJ, Stringer JS, Initiative M-P: Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative. AIDS 2009; 23(Suppl 1):S69-S77.
5. Polis CB, Wawer MJ, Kiwanuka N, Laeyendecker O, Kagaayi J, Lutalo T, Nalugoda F, Kigozi G, Serwadda D, Gray RH: Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda. AIDS 2010; 24:1.
6. Plourde P, Pepin J, Agoki E, Ronald A, Ombette J, Tyndall M, Cheang M, Ndiinya-Achola J, D'Costa L, Plummer F: Human immunodeficiency virus type 1 seroconversion in women with genital ulcers. J Infect Dis 1994; 170:313-317.
7. Martin HL, Nyange PM, Richardson BA, Lavreys L, Mandaliya K, Jackson DJ, Ndinya-Achola JO, Kreiss J: Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1. J Infect Dis 1998; 178:1053-1059.
8. Lavreys L, Chohan V, Overbaugh J, Hassan W, Mcclelland RS, Kreiss J, Mandaliya K, Ndinya-Achola J, Baeten JM: Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women. AIDS 2004; 18:2179-2184.
9. Baeten JM, Benki S, Chohan V, Lavreys L, McClelland RS, Mandaliya K, Ndinya-Achola JO, Jaoko W, Overbaugh J: Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women. AIDS 2007; 21:1771-1777.
10. Morrison CS, Richardson BA, Mmiro F, Chipato T, Celentano DD, Luoto J, Mugerwa R, Padian N, Rugpao S, Brown JM, Cornelisse P, Salata RA, Group HCatRoHAH-HS: Hormonal contraception and the risk of HIV acquisition. AIDS 2007; 21:85-95.
11. Morrison CS, Chen P-L, Kwok C, Richardson BA, Chipato T, Mugerwa R, Byamugisha J, Padian N, Celentano D, Salata R: Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling. AIDS 2010; 24:1777-1778.
12. Plummer F, Simonsen J, Cameron D, Ndinya-Achola J, Kreiss J, Gakinya M, Waiyaki P, Cheang M, Piot P, Ronald A: Cofactors in male-female sexual transmission of human immunodeficiency virus type 1. J Infect Dis 1991; 163:233-239.
13. Kilmarx PH, Limpakarnjanarat K, Mastro TD, Saisorn S, Kaewkungwal J, Korattana S, Uthaivoravit W, Young NL, Weniger BG, St Louis ME: HIV-1 seroconversion in a prospective study of female sex workers in northern Thailand: continued high incidence among brothel-based women. AIDS 1998; 12:1889-1898.
14. Ungchusak K, Rehle T, Thammapornpilap P, Spiegelman D, Brinkmann U, Siraprapasiri T: Determinants of HIV infection among female commercial sex workers in Northeastern Thailand: results from a longitudinal study. J Acquir Immune Defic Syndr Hum Retrovirol 1996; 12:500-507.
15. Sagar M, Kirkegaard E, Long EM, Celum C, Buchbinder S, Daar ES, Overbaugh J: Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes. J Virol 2004; 78:7279-7283.
16. European Study Group on Heterosexual Transmission of HIV: Comparison of female to male and male to female transmission of HIV in 563 stable couples. BMJ 1992; 304:809-813.
17. Baeten JM, Overbaugh J: Measuring the infectiousness of persons with HIV-1: opportunities for preventing sexual HIV-1 transmission. Curr HIV Res 2003; 1:69-86.
18. Pedraza M-A, Romero JD, Roldan F, Garcia S, Ayerbe M-C, Noriega AR, Alcami J: Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in the infected partner. J Acquir Immune Defic Syndr 1999; 21:120-125.
19. Clemetson D, Moss G, Willerfor D, Hensel M, Emonyi W, Holmes K, Plummer F, Ndinya-Achola J, Robers P, Hillier S: Detection of HIV DNA in cervical and vaginal secretions. Prevalance and correlates among women in Nairobi, Kenya. JAMA 1993; 269:2860-2864.
20. Mostad SB, Overbaugh J, DeVange DM, Welch MJ, Chohan B, Mandaliya K, Nyange P, Martin HL, Ndinya-Achola J, Bwayo JJ, Kreiss JK: Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. Lancet 1997; 350:922-927.
21. Kovacs A, Wasserman SS, Burns D, Wright DJ, Cohn J, Landay A, Weber K, Cohen M, Levine A, Minkoff H, Miotti P, Palefsky J, Young M, Reichelderfer P, Group DS, Group WS: Determinants of HIV-1 shedding in the genital tract of women. Lancet 2001; 358:1593-1601.
22. Wang CC, Mcclelland RS, Overbaugh J, Reilly M, Panteleeff DD, Mandaliya K, Chohan B, Lavreys L, Ndinya-Achola J, Kreiss JK: The effect of hormonal contraception on genital tract shedding of HIV-1. AIDS 2004; 18:205-209.
23. Prakash M, Kapembwa MS, Gotch F, Patterson S: Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women. J Reprod Immunol 2002; 54:117-131.
24. Critchlow CW, Wölner-Hanssen P, Eschenbach DA, Kiviat NB, Koutsky LA, Stevens CE, Holmes KK: Determinants of cervical ectopia and of cervicitis: age, oral contraception, specific cervical infection, smoking, and douching. Am J Obstet Gynecol 1995; 173:534-543.
25. Moss G, Clemetson D, D'Costa L, Plummer F, Ndinya-Achola J, Reilly M, Holmes K, Piot P, Maitha G, Hillier S: Association of cervical ectopy with heterosexual transmission of human immunodeficiency virus: results from a study of couples in Nairobi, Kenya. J Infect Dis 1991; 164:588-591.
26. Marx P, Spira A, Gettie A, Dailey P, Veazey R, Lackner A, Mahoney C, Miller C, Claypool L, Ho D, Alexander N: Progesterone implants enhance SIV transmission and early virus load. Nat Med 1996; 2:1084-1089.
27. Smith SM, Mefford M, Sodora D, Klase Z, Singh M, Alexander N, Hess D, Marx PA: Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect. AIDS 2004; 18:1637-1643.
28. Mauck CK, Callahan MM, Baker J, Arbogast K, Veazey R, Stock R, Pan Z, Morrison CS, Chen-Mok M, Archer DF, Gabelnick HL: The effect of one injection of Depo-Provera on the human vaginal epithelium and cervical ectopy. Contraception 1999; 60:15-24.
29. Miller L, Patton DL, Meier A, Thwin SS, Hooton TM, Eschenbach DA: Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium. Obstet Gynecol 2000; 96:431-439.
30. Furth P, Westphal H, Henninghausen L: Expression from the HIV-LTR is stimulated by glucocorticoids and pregnancy. AIDS Res Hum Retroviruses 1990; 6:553-560.
31. Gillgrass AE, Ashkar AA, Rosenthal KL, Kaushic C: Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J Virol 2003; 77:9845-9851.
32. Hunt JS, Miller L, Platt JS: Hormonal regulation of uterine macrophages. Dev Immunol 1998; 6:105-110.
33. Hunt JS, Miller L, Roby KF, Huang J, Platt JS, DeBrot BL: Female steroid hormones regulate production of pro-inflammatory molecules in uterine leukocytes. J Reprod Immunol 1997; 35:87-99.
34. Zang YCQ, Halder JB, Hong J, Rivera VM, Zhang JZ: Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B. J Neuroimmunol 2002; 124:106-114.
35. Baeten JM, Nyange PM, Richardson BA, Lavreys L, Chohan B, Martin HL, Mandaliya K, Ndinya-Achola JO, Bwayo JJ, Kreiss JK: Hormonal contraception and risk of sexually transmitted disease acquisition: results from a prospective study. Am J Obstet Gynecol 2001; 185:380-385.
36. Ghanem KG, Shah N, Klein RS, Mayer KH, Sobel JD, Warren DL, Jamieson DJ, Duerr AC, Rompalo AM, Group HERS: Influence of sex hormones, HIV status, and concomitant sexually transmitted infection on cervicovaginal inflammation. J Infect Dis 2005; 191:358-366.
37. Avonts D, Sercu M, Heyerick P, Vandermeeren I, Meheus A, Piot P: Incidence of uncomplicated genital infections in women using oral contraception or an intrauterine device: a prospective study. Sex Transm Dis 1990; 17:23-29.
38. Louv W, Austin H, Perlman J, Alexander W: Oral contraceptive use and the risk of chlamydial and gonococcal infections. Am J Obstet Gynecol 1989; 160:396-402.
39. Cottingham J, Hunter D: Chlamydia trachomatis and oral contraceptive use: a quantitative review. Genitourin Med 1992; 68:209-216.
40. Morrison CS, Bright P, Wong EL, Kwok C, Yacobson I, Gaydos CA, Tucker HT, Blumenthal PD: Hormonal contraceptive use, cervical ectopy, and the acquisition of cervical infections. Sex Transm Dis 2004; 31:561-567.
41. Prakash M, Patterson S, Gotch F, Kapembwa MS: Ex vivo analysis of HIV-1 co-receptors at the endocervical mucosa of women using oral contraceptives. BJOG 2004; 111:1468-1470.
42. Baeten JM, Mcclelland RS, Corey L, Overbaugh J, Lavreys L, Richardson BA, Wald A, Mandaliya K, Bwayo JJ, Kreiss JK: Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial. J Infect Dis 2004; 189:1466-1471.
43. Mcclelland RS, Wang CC, Mandaliya K, Overbaugh J, Reiner MT, Panteleeff DD, Lavreys L, Ndinya-Achola J, Bwayo JJ, Kreiss JK: Treatment of cervicitis is associated with decreased cervical shedding of HIV-1. AIDS 2001; 15:105-110.
44. Baeten JM, Hassan WM, Chohan V, Richardson BA, Mandaliya K, Ndinya-Achola JO, Jaoko W, Mcclelland RS: Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women. Sex Transm Infect 2009; 85:348-353.
45. Martin HL, Richardson BA, Nyange PM, Lavreys L, Hillier SL, Chohan B, Mandaliya K, Ndinya-Achola JO, Bwayo J, Kreiss J: Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180:1863-1868.