A cytokine switch induced by human seminal plasma: An immune modulation with implications for sexually transmitted disease

Human Reproduction

Volumn 12, Issue 4, 1997, Pages 677-681

  Kelly, Rodney W ^a   Carr, Gail G ^a   Critchley, Hilary O D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Anergy; Cytokine production; Immunomodulation; Seminal plasma

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; PROSTAGLANDIN E;

ARTICLE; BLOOD CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; NORMAL HUMAN; SEMINAL PLASMA; SEXUALLY TRANSMITTED DISEASE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030968221     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.4.677     Document Type: Article

References (36)

1. Artenstein, A.W., Coppola, J., Brown, A.E. et al. (1995) Multiple introductions of HIV-1 subtype E into the western hemisphere. Lancet, 346, 1197-1198.
2. Baier, M., Werner, A., Bannert, N. et al. (1995) HIV suppression by interleukin-16. Nature, 368, p. 563.
3. Barker, E., Mackewicz, C.E. and Levy, J.A. (1995) Effects of T(H)1 and T(H)2 cytokines on Cd8(+) cell response against human-immunodeficiency-virus - implications for long-term survival. Proc. Natl Acad. Sci. USA, 92, 11135-11139.
4. Bogdan, C., Paik, J., Vodovotz, Y. and Nathan, C. (1992) Contrasting mechanisms for suppression of macrophage cytokine release by TGFβ and IL-10. J. Biol. Chem., 267, 23301-23308.
5. Chehimi, J., Starr, S.E., Frank, I. et al (1994) Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J. Exp. Med., 179, 1361-1366.
6. Chehimi, J., Starr, S.E., Frank, I. et al. (1992) Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus infected patients. J. Exp. Med., 175, 789-796.
7. Cocchi, F., Devico, A.L., Garzinodemo, A. et al (1995) Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8(+) T-cells. Science, 270, 1811-1815.
8. D'Andrea, A., Aste-Amezaga, M., Valiante, N. et al. (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med., 178, 1041-1048.
9. Dragic, T., Litwin, V., Allaway, G.P. et al. (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature, 381, 667-673.
10. Dussaix, E., Guetard, D., Dauguet, C. et al. (1993) Spermatozoa as potential carriers of HIV. Res. Virol., 144, 487-495.
11. Foley, P., Kazazi, F., Biti, R. et al (1992) HIV infection of monocytes inhibits the T-lymphocyte proliferative response to recall antigens, via production of eicosanoids. J. Immunol., 75, 391-397.
12. Gil, T., Castilla, J.A., Hortas, M.L. et al. (1995) CD4+ cells in human ejaculate. Hum. Reprod., 10, 2923-2927.
13. Groux, H., Bigler, M., de Vries, J.E. and Roncarolo, M.G. (1996) Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J. Exp. Med., 184, 19-29.
14. Hilkens, C.M.U., Snijders, A., Vermeulen, H. et al. (1996) Accessory cell-derived IL-12 and prostaglandin E(2) determine the Ifn-gamma level of activated human Cd4(+) T-cells. J. Immunol., 156, 1722-1727.
15. James, K. and Hargreave, T.B. (1984) Immunosuppression by seminal plasma and its possible clinical significance, Immunol. Today, 5, 357-363.
16. Kelly, R.W. (1995) Immunosuppressive mechanisms in semen: implications for contraception. Hum. Reprod., 10, 1686-1693.
17. Kelly, R.W., Holland, P., Skibinski G. et al. (1991) Extracellular organelles (prostasomes) are immunosuppressive components of human semen. Clin. Exptl. Immunol. 86, 550-556.
18. Kraan, T.C.T.M.V., Boeije, L.C.M., Smeenk, R.J.T. et al. (1995) Prostaglandin-E2 is a potent inhibitor of human interleukin-12 production. J. Exp. Med., 181, 775-779.
19. Lang, D.J. and Kummer, J.F. (1972) Demonstration of cytomegalovirus in semen. N. Engl. J. Med., 287, 756-758.
20. Levy, J.A. (1994) Humoral and cell mediated immune responses to HIV infection. In HIV and the Pathogenesis of AIDS. ASM Press, Washington, pp. 153-180.
21. Longo, N., Zabay, J M., Sempere, J.M., Navarro, J. and Fernandezcruz, E. (1993) Altered production of PGE(2), IL-1β and TNFα by peripheral-blood monocytes from HIV-positive individuals at early stages of HIV-infection. J. Acquir. Immun. Def. Synd., 6, 1017-1023.
22. Macatonia, S.E., Hosken, N.A., Litton, M. et al. (1995) Dendritic cells produce Il-12 and direct the development of Th1 cells from naive Cd4(+) T-cells. J. Immunol., 154, 5071-5079.
23. Mertz, P.M., DeWitt, D.L., Stetler Stevenson, W.G. and Wahl, L. M. (1994) Interleukin 10 suppression of monocyte prostaglandin H synthase - 2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production. J. Biol. Chem., 269, 21322-21329.
24. Miao, D., Skibinski, G. and James, K. (1996) The effects of human seminal plasma and PGE2 on mitogen induced proliferation and cytokine production of human splenic lymphocytes and peripheral blood mononuclear cells. J. Reprod. Immunol., 30, 97-114.
25. Niiro, H., Otsuka, T, Kuga, S. et al. (1994) IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes. Int. Immunol., 6, 661-664.
26. Nuovo, G.J., Becker, J., Simsir, A. et al. (1994) HIV-1 nucleic-acids localize to the spermatogonia and their progeny - a study by polymerase chain-reaction in-situ hybridization. Am. J. Pathol., 144, 1142-1148.
27. Quayle, A.J., Kelly, R.W., Hargreave, T.B. and James, K. (1989) Immunosuppression by seminal prostaglandins. Clin. Exp. Immunol., 75, 387-391.
28. Soto-Ramirez, L.E., Renjifo, B., McLane, M.F. et al. (1996) HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV. Science, 271, 1291-1293.
29. Strassmann, G., Patil Koota, V, Finkelman, F. et al. (1994) Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med., 180, 2365-2370.
30. Taga, K. and Tosato, G. (1992) IL-10 inhibits human T cell proliferation and IL-2 production. J. Immunol., 148, 1143-1148.
31. Tarter, T.H., Cunningham-Rundles, S. and Koide, S.S. (1986) Suppression of natural killer cell activity by human seminal plasma in vitro: identification of 19-OH-PGE as the suppressor factor. J. Immunol., 136, 2862-2867.
32. Trinchieri, G. (1993) IL-12 and its role in the generation of Th1 cells. Immunol. Today, 14, 335-338.
33. Van Voorhis, B.J., Martinez, A., Mayer, K. and Anderson, D.J. (1991) Detection of human immunodeficiency virus type 1 in semen from seropositive men using culture and polymerase chain reaction deoxyribonucleic acid amplification techniques. Fertil. Steril., 55, 588-594.
34. Wang, L., Goillot, E. and Tepper, R.I. (1994) Il-10 inhibits alloreactive cytotoxic T-lymphocyte generation in-vivo. Cellul. Immunol., 159, 152-169.
35. Zambruno, G., Giannetti, A., Bertazzoni, U. and Girolomoni, G. (1995) Langerhans cells and HIV infection, Immunol. Today, 16, 520-524.
36. Zur Hausen, H. (1982) Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events? Lancet, 2, 1370-1372.