Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 11, 1999, Pages 4055-4061

  Bamberger, Christoph M ^a,b   Else, Tobias ^b   Bamberger, Ana Maria ^a   Beil, Frank Ulrich ^a   Schulte, Heinrich M ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; PROGESTERONE RECEPTOR;

ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE REPRESSION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0033310360     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.11.4055     Document Type: Article

References (36)

1. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
2. Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune disease
3. Glucocortico-steroid action on the immune system: Molecular and cellular aspects
4. The steroid and thyroid hormone receptor superfamily
5. Steroid hormone receptors: Interaction with deoxyribonucleic acid and transcription factors
6. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
7. Steroid hormone receptors: Many actors in search of a plot
8. The nuclear receptor superfamily: The second decade
9. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
10. In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone
11. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids
12. Mechanisms for inducible control of angiotensinogen gene transcription
13. Transcriptional regulation of the human leukemia inhibitory factor gene: Modulation by glucocorticoids and estradiol
14. Negative regulation of interleukin 2 transcription by the glucocorticoid receptor
15. Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements
16. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transciption factors AP-1 and NF-AT
17. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
18. Functional antagonism between oncoprotein c-jun and the glucocorticoid receptor
19. Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
20. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors
21. Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes
22. Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog
23. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells
24. Regulation of the human interleukin-2 (IL-2) gene by the α and β isoforms of the glucocorticoid receptor
25. Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor
26. Inhibition of mineralocorticoid activity by the β-isoform of the human glucocorticoid receptor
27. Effect of synthetic progestational agents on allograft rejection and circulating antibody production
28. Mechanism of immunosuppression of progesterone on maternal lymphocyte activation during pregnancy
29. Progesterone-induced immunosuppression is not mediated through the progesterone receptor
30. Effect of tamoxifen and high-dose medroxyprogesterone acetate (MPA) on cell-mediated immune functions in breast cancer patients
31. Expression of the gene coding for the progesterone receptor in activated human lymphocytes
32. Induction properties of a transiently transfected glucocorticoid-responsive gene vary with glucocorticoid receptor concentrations
33. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo
34. The influence of high doses of oral medroxyprogesterone acetate on glucose tolerance, serum insulin levels and adrenal response to ACTH. A study of 17 patients under treatment for endometrial cancer
35. Medroxyprogesterone acetate lowers plasma corticotropin and cortisol but does not suppress anterior pituitary responsiveness to human corticotropin releasing hormone
36. Effective therapy of glucocorticoid-induced osteoporosis with medroxyprogesterone acetate