Maintenance of native-like protein dynamics may not be required for engineering functional proteins

Chemistry and Biology

Volumn 21, Issue 10, 2014, Pages 1330-1340

  Gobeil, Sophie M C ^a,b   Clouthier, Christopher M ^a,b   Park, Jaeok ^a,c   Gagné, Donald ^a,c   Berghuis, Albert M ^a,c   Doucet, Nicolas ^a,c   Pelletier, Joelle N ^a,b,d  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d Center for Green Chemistry and Catalysis   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE TEM 1; CHIMERIC PROTEIN; NITROGEN 15; BETA-LACTAMASE PSE-4; BETA-LACTAMASE TEM-1; HYBRID PROTEIN; NITROGEN; PROTEIN;

ARTICLE; CATALYSIS; CHIMERA; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME METABOLISM; ENZYME STRUCTURE; GENETIC CONSERVATION; HOMOLOGOUS RECOMBINATION; MOLECULAR DYNAMICS; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

BETA-LACTAMASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MOLECULAR DYNAMICS SIMULATION; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RECOMBINANT FUSION PROTEINS;

EID: 84908329345     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.07.016     Document Type: Article

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