Conservation of flexible residue clusters among structural and functional enzyme homologues

Journal of Biological Chemistry

Volumn 287, Issue 53, 2012, Pages 44289-44300

  Gagné, Donald ^a   Charest, Laurie Anne ^a   Morin, Sébastien ^b   Kovrigin, Evgenii L ^c   Doucet, Nicolas ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITY OF BASEL   (Switzerland)

^c MARQUETTE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC FUNCTIONS; CATALYTIC RESIDUE; CATIONIC PROTEINS; CONFORMATIONAL FLEXIBILITY; ENZYME CATALYSIS; ENZYME FOLD; ENZYME FUNCTIONS; ESSENTIAL COMPONENT; FUNCTIONAL ENZYMES; MODEL-FREE ANALYSIS; MULTIPLE TIME SCALE; NMR RELAXATION DISPERSION; PANCREATIC RIBONUCLEASE; PROTEIN FOLDS; RNASE A; SEQUENCE IDENTITY; STRUCTURAL ORGANIZATION; TIME-SCALES;

CATALYSIS; ENZYMES; PROTEIN FOLDING; PROTEINS; TITRATION;

SCAFFOLDS (BIOLOGY);

EOSINOPHIL CATIONIC PROTEIN; RIBONUCLEASE; RIBONUCLEASE A;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHIMERA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; LIGAND BINDING; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FOLDING; PROTEIN FUNCTION; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE MONOPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; EOSINOPHIL CATIONIC PROTEIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RIBONUCLEASE, PANCREATIC;

EID: 84871735453     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.394866     Document Type: Article

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