Structure, function, and inhibition along the reaction coordinate of CTX-M β-lactamases

Journal of the American Chemical Society

Volumn 127, Issue 15, 2005, Pages 5423-5434

  Chen, Yu ^a   Shoichet, Brian ^a   Bonnet, Richard ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; ANTIBIOTICS; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROLYSIS; REACTION KINETICS;

CEFOXITIN; DEACYLATION; ENZYME COMPLEXES; EXTENDED SPECTRUM Β-LACTAMASES (ESBL);

ENZYMES;

BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BORONIC ACID DERIVATIVE; CEFOXITIN; CEFTAZIDIME;

ACYLATION; ANTIBIOTIC RESISTANCE; ARTICLE; CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEACETYLATION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; IC 50; NONHUMAN; PHASE TRANSITION; PROTEIN EXPRESSION; PROTEIN FUNCTION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BINDING SITES; BORONIC ACIDS; CATALYSIS; CEFOXITIN; CRYSTALLOGRAPHY, X-RAY; HEAT; ISOENZYMES; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN DENATURATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17644390560     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja042850a     Document Type: Article

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