Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 β-lactamase

Journal of Biological Chemistry

Volumn 279, Issue 44, 2004, Pages 46295-46303

  Doucet, Nicolas ^a   De Wals, Pierre Yves ^a   Pelletier, Joelle N ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; ENZYME INHIBITION; ENZYMES; ESCHERICHIA COLI; MOLECULAR DYNAMICS; STABILIZATION; SUBSTITUTION REACTIONS;

AROMATIC RESIDUES; ENZYME ACTIVITY; GLYCINE; SITE-SATURATION MUTAGENESIS;

MUTAGENESIS;

ALANINE; AMPICILLIN; ASPARAGINE; BETA LACTAMASE; CEFALOTIN; CEFAZOLIN; CEFOTAXIME; CEPHALOSPORIN DERIVATIVE; GLYCINE; PENICILLIN DERIVATIVE; PENICILLIN G; TEM BETA LACTAMASE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SATURATION MUTAGENESIS; STEREOCHEMISTRY;

BETA-LACTAMASES; BINDING SITES; COMPUTER SIMULATION; ESCHERICHIA COLI; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; FELIS CATUS;

EID: 8544219754     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407606200     Document Type: Article

References (40)

1. Orencia, M. C., Yoon, J. S., Ness, J. E., Stemmer, W. P., and Stevens, R. C. (2001) Nat. Struct. BM. 8, 238-242
2. Matagne, A., and Frère, J. M. (1995) Biochim. Biaphys. Acta 1246, 109-127
3. Matagne, A., Lamotte-Brasseur, J., and Frère, J. M. (1998) Biochem. J. 330, 581-598
4. Knox, J. R. (1995) Antimicrob. Agents Chemother. 39, 2593-2601
5. Yang, Y., Rasmussen, B. A., and Shlaes, D. M. (1999) Pharmacol. Ther. 83, 141-151
6. Minasov, G., Wang, X., and Shoichet, B. K. (2002) J. Am. Chem. Soc. 124, 5333-5340
7. Chen, C. C., and Herzberg, O. (2001) Biochemistry 40, 2351-2358
8. Strynadka, N. C. J., Adachi, H., Jensen, S. E., Johns, K., Sielecki, A., Betzel, C., Sutoh, K., and James, M. N. G. (1992) Nature 359, 700-705
9. Tranier, S., Bouthors, A. T., Maveyraud, L., Guillet, V., Sougakoff, W., and Samama, J. P. (2000) J. Boil. Chem. 275, 28075-28082
10. Shimamura, T., Ibuka, A., Fushinobu, S., Wakagi, T., Ishiguro, M., Ishii, Y., and Matsuzawa, H. (2002) J. Biol. Chem. 277, 46601-46608
11. Meroueh, S. O., Roblin, P., Golemi, D., Maveyraud, L., Vakulenko, S. B., Zhang, Y., Samama, J. P., and Mobashery, S. (2002) J. Am. Chem. Soc. 124, 9422-9430
12. Díaz, N., Sordo, T. L., Merz, K. M., Jr., and Suárez, D. (2003) J. Am. Chem. Soc. 125, 672-684
13. Castillo, R., Silla, E., and Tuñón, I. (2002) J. Am. Chem. Soc. 124,1809-1816
14. Abraham, E. P., and Chain, E. (1940) Nature 146, 837
15. Escobar, W. A., Miller, J., and Fink, A. L. (1994) Biochem. J. 303, 555-558
16. Di Gleria, K., Halliwell, C. M., Jacob, C., and Hill, H. A. (1997) FEBS Lett. 400, 155-157
17. Chen, C. C., Rahil, J., Pratt, R. F., and Herzberg, O. (1993) J. Mol. Biol. 234, 165-178
18. Guo, F., Huynh, J., Dmitrienko, G. I., Viswanatha, T., and Clarke, A. J. (1999) Biochim. Biophys. Acta 1431, 132-147
19. Wang, X., Minasov, G., Blázquez, J., Caselli, E., Prati, F., and Shoichet, B. K. (2003) Biochemistry 42, 8434-8444
20. Maveyraud, L., Mourey, L., Kotra, L. P., Pedelacq, J. D., Guillet, V., Mobashery, S., and Samama, J. P. (1998) J. Am. Chem. Soc. 120, 9748-9752
21. Strynadka, N. C. J., Martin, R., Jensen, S. E., Gold, M., and Jones, J. B. (1996) Nat. Struct. Biol. 3, 688-695
22. Strynadka, N. C. J., Jensen, S. E., Alzari, P. M., and James, M. N. G. (1996) Nat. Struct. Biol. 3, 290-297
23. Page, M. G. F. (2000) Drug Resist. Updat. 3, 109-125
24. Huang, W. Z., Petrosino, J., Hirsch, M., Shenkin, P. S., and Palzkill, T. (1996) J. Mol. Biol. 258, 688-703
25. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
26. Cantu, C., III, Huang, W., and Palzkill, T. (1996) J. Biol. Chem. 271, 22538-22545
27. Bouthors, A. T., Dagoneau-Blanchard, N., Naas, T., Nordmann, P., Jarlier, V., and Sougakoff, W. (1998) Biochem. J. 330, 1443-1449
28. Jelsch, C., Mourey, L., Masson, J. M., and Samama, J. P. (1993) Proteins 16, 364-383
29. Bush, K., and Mobashery, S. (1998) Adv. Exp. Med. Biol. 456, 71-98
30. Page, M. I. (1987) Adv. Phys. Org. Chem. 23, 165-270
31. Wolozin, B. L., Myerowitz, R., and Pratt, R. F. (1982) Biochim. Biophys. Acta 701, 153-163
32. Taibi-Tronche, P., Massova, I., Vakulenko, S. B., Lerner, S. A., and Mobashery, S. (1996) J. Am. Chem. Soc. 118, 7441-7448
33. Bulychev, A., Obrien, M. E., Massova, I., Teng, M., Gibson, T. A., Miller, M. J., and Mobashery, S. (1995) J. Am. Chem. Soc. 117, 5938-5943
34. Maveyraud, L., Massova, I., Birck, C., Miyashita, K., Samama, J. P., and Mobashery, S. (1996) J. Am. Chem. Soc. 118, 7435-7440
35. Ness, S., Martin, R., Kindler, A. M., Paetzel, M., Gold, M., Jensen, S. E., Jones, J. B., and Strynadka, N. C. (2000) Biochemistry 39, 5312-5321
36. Moews, P. C., Knox, J. R., Dideberg, O., Charlier, P., and Frère, J. M. (1990) Proteins 7, 156-171
37. Zafaralla, G., Manavathu, E. K., Lerner, S. A., and Mobashery, S. (1992) Biochemistry 31, 3847-3852
38. Dideberg, O., Charlier, P., Wery, J. P., Dehottay, P., Dusart, J., Erpicum, T., Frère, J. M., and Ghuysen, J. M. (1987) Biochem. J. 245, 911-913
39. Swarén, P., Maveyraud, L., Raquet, X., Cabantous, S., Duez, C., Pedelacq, J. D., Mariotte-Boyer, S., Mourey, L., Labia, R., Nicolas-Chanoine, M. H., Nordmann, P., Frère, J. M., and Samama, J. P. (1998) J. Biol. Chem. 273, 26714-26721
40. Ambler, R. P., Coulson, A. F., Frère, J. M., Ghuysen, J. M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., and Waley, S. G. (1991) Biochem. J. 276, 269-270