The flexibility of a distant loop modulates active site motion and product release in ribonuclease A

Biochemistry

Volumn 48, Issue 30, 2009, Pages 7160-7168

  Doucet, Nicolas ^a   Watt, Eric D ^a   Loria, J Patrick ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCHEMICAL EXPERIMENTS; CATALYTIC CYCLES; CATIONIC PROTEINS; CHIMERIC ENZYMES; CONFORMATIONAL CHANGE; LOCAL PERTURBATION; PRODUCT RELEASE; RATE LIMITING; RIBONUCLEASE A; RNASE A;

CHEMICAL SHIFT; RATE CONSTANTS;

ENZYMES;

CYTIDINE PHOSPHATE; EOSINOPHIL CATIONIC PROTEIN; HYBRID PROTEIN; PANCREATIC RIBONUCLEASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PLIABILITY; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CATTLE; CYTIDINE MONOPHOSPHATE; EOSINOPHIL CATIONIC PROTEIN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLIABILITY; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RIBONUCLEASE, PANCREATIC; THERMODYNAMICS;

EID: 70350729303     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi900830g     Document Type: Article

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