Structure and Dynamics of CTX-M Enzymes Reveal Insights into Substrate Accommodation by Extended-spectrum β-Lactamases

Journal of Molecular Biology

Volumn 375, Issue 1, 2008, Pages 192-201

  Delmas, Julien ^a,b   Chen, Yu ^c   Prati, Fabio ^d   Robin, Frédéric ^a,b   Shoichet, Brian K ^c   Bonnet, Richard ^a,b  

^a UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

ceftazidime; CTX M; spectrum; structure; lactamases

Indexed keywords

ANTIBIOTIC AGENT; ASPARTIC ACID; BACTERIAL ENZYME; BETA LACTAM; BETA LACTAMASE; BORONIC ACID DERIVATIVE; CEFOTAXIME; CEFTAZIDIME; EXTENDED SPECTRUM BETA LACTAMASE; GLYCINE; SERINE;

ACYLATION AND DEACYLATION; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION; CRYSTALLOGRAPHY; DRUG STRUCTURE; DYNAMICS; ENZYME PURIFICATION; ESCHERICHIA COLI; GEL FILTRATION; HYDROLYSIS; ION EXCHANGE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

BACTERIA (MICROORGANISMS);

EID: 36348944684     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.10.026     Document Type: Article

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