Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae

Neuroscience

Volumn 280, Issue , 2014, Pages 299-317

  Grace, P M ^a   Ramos, K M ^a   Rodgers, K M ^a   Wang, X ^a   Hutchinson, M R ^b   Lewis, M T ^a   Morgan, K N ^a   Kroll, J L ^a   Taylor, F R ^a   Strand, K A ^a   Zhang, Y ^a   Berkelhammer, D ^a   Huey, M G ^a   Greene, L I ^a   Cochran, T A ^a   Yin, H ^a   Barth, D S ^a   Johnson, K W ^c   Rice, K C ^d   Maier, S F ^a   Watkins, L R ^a   more..

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c MediciNova Inc   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

CTAP; Endothelial cell; M3G; Morphine; Nalmefene; TLR4

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; IBUDILAST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MORPHINE; MORPHINE 3 GLUCURONIDE; NALMEFENE; OPIATE; PROPENTOFYLLINE; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; MORPHINE DERIVATIVE; MORPHINE-3-GLUCURONIDE; MU OPIATE RECEPTOR; NARCOTIC AGENT; PTGS2 PROTEIN, RAT; TLR4 PROTEIN, RAT;

ADULT; ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; COX2 GENE; EMBRYO; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; NK KAPPAB GENE; NONHUMAN; PROSTAGLANDIN RELEASE; RAT; SIGNAL TRANSDUCTION; TNF ALPHA GENE; UPREGULATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CENTRAL NERVOUS SYSTEM; DRUG EFFECTS; GLIA; HYPERALGESIA; IMMUNOMODULATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; VASODILATATION;

ANIMALS; CENTRAL NERVOUS SYSTEM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOTHELIAL CELLS; HYPERALGESIA; MALE; MORPHINE; MORPHINE DERIVATIVES; NARCOTICS; NEUROGLIA; NEUROIMMUNOMODULATION; NF-KAPPA B; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION;

EID: 84908271380     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.09.020     Document Type: Article

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