Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice

British Journal of Pharmacology

Volumn 165, Issue 5, 2012, Pages 1319-1329

  Wu, Yue ^a   Lousberg, Erin L ^b,c   Moldenhauer, Lachlan M ^a   Hayball, John D ^a,b,c   Coller, Janet K ^a   Rice, Kenner C ^d   Watkins, Linda R ^e   Somogyi, Andrew A ^a   Hutchinson, Mark R ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b HANSON INSTITUTE   (Australia)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

alcohol; I B ; loss of righting reflex; mice studies; motor impairment; MyD88; sedation; TLR4

Indexed keywords

ALCOHOL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; NALOXONE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EX VIVO STUDY; GENE PRODUCT; GENETIC DISORDER; HIPPOCAMPUS; IN VITRO STUDY; LOSS OF RIGHTING REFLEX; MALE; MOTOR DYSFUNCTION; MOUSE; MUTATIONAL ANALYSIS; MYD88 GENE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; RIGHTING REFLEX; ROTAROD TEST; SEDATION; SIGNAL TRANSDUCTION; TLR4 GENE;

ANIMALS; ETHANOL; HIPPOCAMPUS; HYPNOTICS AND SEDATIVES; I-KAPPA B PROTEINS; MALE; MAP KINASE KINASE 4; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOTOR NEURONS; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NALOXONE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84863115604     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01572.x     Document Type: Article

References (54)

1. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edn. Br J Pharmacol 164 (Suppl. 1): S1-S324.
2. Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I, Guerri C, (2010). Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J Neurosci 30: 8285-8295.
3. Alling C, Gustavsson L, Hansson E, Ronnback L, (1986). Lipids and fatty acids in membranes from astroglial cells cultured in ethanol-containing media. Drug Alcohol Depend 18: 115-126.
4. Arlinde C, Sommer W, Bjork K, Reimers M, Hyytia P, Kiianmaa K, et al,. (2004). A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism. Pharmacogenomics J 4: 208-218.
5. Beauvillain C, Donnou S, Jarry U, Scotet M, Gascan H, Delneste Y, et al,. (2008). Neonatal and adult microglia cross-present exogenous antigens. Glia 56: 69-77.
6. Bjork K, Terasmaa A, Sun H, Thorsell A, Sommer WH, Heilig M, (2010). Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors. Addict Biol 15: 299-303.
7. Blanco AM, Pascual M, Valles SL, Guerri C, (2004). Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B. Neuroreport 15: 681-685.
8. Blanco AM, Valles SL, Pascual M, Guerri C, (2005). Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J Immunol 175: 6893-6899.
9. Blanco AM, Perez-Arago A, Fernandez-Lizarbe S, Guerri C, (2008). Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells. J Neurochem 106: 625-639.
10. Blednov YA, Bergeson SE, Walker D, Ferreira VM, Kuziel WA, Harris RA, (2005). Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res 165: 110-125.
11. Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA, (2011). Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun 25: S92-105.
12. Boyce-Rustay JM, Holmes A, (2005). Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice. Synapse 56: 222-225.
13. Carnicella S, Kharazia V, Jeanblanc J, Janak PH, Ron D, (2008). GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci USA 105: 8114-8119.
14. Carta M, Mameli M, Valenzuela CF, (2004). Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability. J Neurosci 24: 3746-3751.
15. Chuck TL, McLaughlin PJ, Arizzi-LaFrance MN, Salamone JD, Correa M, (2006). Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia. Life Sci 79: 154-161.
16. Drugan RC, Wiedholz LM, Holt A, Kent S, Christianson JP, (2007). Environmental and immune stressors enhance alcohol-induced motor ataxia in rat. Pharmacol Biochem Behav 86: 125-131.
17. Fernandez-Lizarbe S, Pascual M, Gascon MS, Blanco A, Guerri C, (2008). Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages. Mol Immunol 45: 2007-2016.
18. Fernandez-Lizarbe S, Pascual M, Guerri C, (2009). Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol 183: 4733-4744.
19. Ferreiro DU, Komives EA, (2010). Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha. Biochemistry 49: 1560-1567.
20. Hansson E, Gustavsson L, Jonsson G, Alling C, Ronnback L, (1987). Astroglial primary cultures: a model to study ethanol effects on the cell membrane lipid composition. Alcohol Alcohol Suppl 1: 679-683.
21. He J, Crews FT, (2008). Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp Neurol 210: 349-358.
22. Heinisch S, Kirby LG, (2010). SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology 58: 501-514.
23. Hirono M, Yamada M, Obata K, (2009). Ethanol enhances both action potential-dependent and action potential-independent GABAergic transmission onto cerebellar Purkinje cells. Neuropharmacology 57: 109-120.
24. Hua F, Ma J, Ha T, Xia Y, Kelley J, Williams DL, et al,. (2007). Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. J Neuroimmunol 190: 101-111.
25. Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, et al,. (2008). Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci 28: 20-29.
26. Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, et al,. (2010a). Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience 167: 880-893.
27. Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, et al,. (2010b). Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun 24: 83-95.
28. Hyman SE, Malenka RC, Nestler EJ, (2006). Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29: 565-598.
29. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, et al,. (2000). Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287: 1056-1060.
30. Kiefer F, Jahn H, Koester A, Montkowski A, Reinscheid RK, Wiedemann K, (2003). Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol. Biol Psychiatry 53: 345-351.
31. Kleiman-Wexler RL, Adair CG, Ephgrave KS, (1989). Pharmacokinetics of naloxone: an insight into the locus of effect on stress-ulceration. J Pharmacol Exp Ther 251: 435-438.
32. Lin MR, Kraus JF, (2009). A review of risk factors and patterns of motorcycle injuries. Accid Anal Prev 41: 710-722.
33. Linden AM, Schmitt U, Leppa E, Wulff P, Wisden W, Luddens H, et al,. (2011). Ro 15-4513 antagonizes alcohol-induced sedation in mice through alphabetagamma2-type GABA(A) receptors. Front Neurosci 5: 3.
34. A α2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proc Natl Acad Sci USA 108: 4465-4470.
35. Lousberg EL, Fraser CK, Tovey MG, Diener KR, Hayball JD, (2010). Type I interferons mediate the innate cytokine response to recombinant fowlpox virus but not the induction of plasmacytoid dendritic cell-dependent adaptive immunity. J Virol 84: 6549-6563.
36. McClain JA, Morris SA, Deeny MA, Marshall SA, Hayes DM, Kiser ZM, et al,. (2011). Adolescent binge alcohol exposure induces long-lasting partial activation of microglia. Brain Behav Immun 25: S120-S128.
37. Mukherjee S, Das SK, Vaidyanathan K, Vasudevan DM, (2008). Consequences of alcohol consumption on neurotransmitters-an overview. Curr Neurovasc Res 5: 266-272.
38. Ortiz J, Fitzgerald LW, Charlton M, Lane S, Trevisan L, Guitart X, et al,. (1995). Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 21: 289-298.
39. Pascual M, Balino P, Alfonso-Loeches S, Aragon CM, Guerri C, (2011). Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage. Brain Behav Immun 25: S80-S91.
40. Prow NA, Irani DN, (2008). The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. J Neurochem 105: 1276-1286.
41. Ren K, Dubner R, (2008). Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Curr Opin Anaesthesiol 21: 570-579.
42. Ronnback L, Hansson E, Alling C, (1988). Primary astroglial cultures in alcohol and drug research. Alcohol Alcohol 23: 465-475.
43. Schuckit MA, Smith TL, Kalmijn J, (2004). The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. Alcohol Clin Exp Res 28: 1449-1458.
44. Scott ML, Fujita T, Liou HC, Nolan GP, Baltimore D, (1993). The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev 7: 1266-1276.
45. Smolen TN, Smolen A, (1989). Blood and brain ethanol concentrations during absorption and distribution in long-sleep and short-sleep mice. Alcohol 6: 33-38.
46. Streit WJ, Mrak RE, Griffin WS, (2004). Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1: 14.
47. Sun SC, Ganchi PA, Ballard DW, Greene WC, (1993). NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259: 1912-1915.
48. Szabo G, Bala S, (2010). Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 16: 1321-1329.
49. Valenzuela CF, Lindquist B, Zamudio-Bulcock PA, (2010). A review of synaptic plasticity at Purkinje neurons with a focus on ethanol-induced cerebellar dysfunction. Int Rev Neurobiol 91: 339-372.
50. Valles SL, Blanco AM, Pascual M, Guerri C, (2004). Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol 14: 365-371.
51. Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M, (2009). Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 33: 945-969.
52. Wand G, Levine M, Zweifel L, Schwindinger W, Abel T, (2001). The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci 21: 5297-5303.
53. WHO (2004). WHO Global Status Report on Alcohol 2004. WHO: Geneva.
54. Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Robertson SA, Coller JK, et al,. (2011). Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain Behav Immun 25: S155-S164.