Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: Light and electron microscopic immunocytochemical studies

Journal of Neuroscience

Volumn 18, Issue 16, 1998, Pages 6279-6289

  Matsumura, Kiyoshi ^a   Cao, Chunyu ^b   Ozaki, Masashi ^b   Morii, Hiroshi ^b   Nakadate, Kazuhiko ^b   Watanabe, Yasuyoshi ^b  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b NONE

Author keywords

Brain endothelial cells; Cyclooxygenase 2; Fever; Immune CNS communication; Lipopolysaccharide; Prostaglandins

Indexed keywords

LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD VESSEL; FEVER; IMMUNOFLUORESCENCE TEST; IMMUNOSTIMULATION; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM;

EID: 0032529719     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-16-06279.1998     Document Type: Article

References (28)

1. Blalock JE (1989) A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev 69:1-32.
2. Blatteis CM, Sehic E (1997) Fever: how may circulating pyrogens signal the brain? News Physiol Sci 12:1-9.
3. Breder CD, Saper CB (1996) Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res 713:64-69.
4. Breder CD, Dewitt D, Kraig RP (1995) Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355:296-315.
5. Cao C, Matsumura K, Yamagata K, Watanabe Y (1995) Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res 697:187-196.
6. Cao C, Matsumura K, Yamagata K, Watanabe Y (1996) Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever. Brain Res 733:263-272.
7. Cao C, Matsumura K, Yamagata K, Watanabe Y (1997) Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA in the rat brain by LPS. Am J Physiol 272:R1712-R1725.
8. Cunningham JET, Wada E, Carter DB, Tracey DE, Battey JF, De Souza EB (1992) In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. J Neurosci 12:1101-1114.
9. de Vries HE, Hoogendoorn KH, van Dijk J, Zijlstra FJ, van Dam A-M, Breimer DD, van Berkel TJC, de Boer AG, Kuiper J (1995) Eicosanoid production by rat cerebral endothelial cells: stimulation by lipopolysaccharide, interleukin-1 and interleukin-6. J Neuroimmunol 59:1-8.
10. Dinarello CA, Cannon JG, Wolf SM (1988) New concept on the pathogenesis of fever. Rev Infect Dis 10:168-190.
11. Elmquist JK, Breder CD, Sherin JE, Scammell TE, Hickey WF, Dewitt D, Saper CB (1997) Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J Comp Neurol 381:119-129.
12. Ericsson A, Arias C, Sawchenko PE (1997) Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. J Neurosci 17:7166-7179.
13. Goppelt-Struebe M (1995) Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression. Prostaglandins Leukot and Essent Fatty Acids 52:213-222.
14. Herschman HR (1996) Prostaglandin synthase 2. Biochim Biophys Acta 1299:125-140.
15. Jaffe EA, Hoyer LW, Nachman RL (1973) Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest 52:2757-2764.
16. Kent S, Bluthé RM, Kelley KW, Danzer R (1992) Sickness behavior as a new target for drug development. Trends Pharmacol Sci 13:24-28.
17. Kluger MJ (1991) Fever: role of pyrogens and cryogens. Physiol Rev 71:93-127.
18. Koll S, Goppelt-Struebe M, Hauser I, Goerig M (1997) Monocyticendothelial cell interaction: regulation of prostanoid synthesis in human coculture. J Leukoc Biol 61:679-688.
19. 2 binding sites in the anterior wall of the 3rd ventricle: a possible site of its hyperthermic action. Brain Res 533:147-151.
20. 2 binding sites in rat brain using quantitative autoradiography. Brain Res 581:292-298.
21. 3H]iloprost. Neuroscience 65:493-503.
22. Matsumura K, Cao C, Watanabe Yu, Watanabe Y (1998) Prostaglandin system in the brain: sites of biosynthesis and sites of action under normal and hyperthermic conditions. Prog Brain Res, 115:275-295.
23. Milton AS (1982) Prostaglandins in fever and the mode of action of antipyretic drugs. In: Pyretics and antipyretics (Milton AS, ed), pp 259-267. Berlin: Springer.
24. Scammell TE, Elmquist JK, Griffin JD, Saper CB (1996) Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways. J Neurosci 16:6246-6254.
25. Stitt JT (1986) Prostaglandin E as the neural mediator of the febrile response. Yale J Biol Med 59:137-149.
26. Takechi H, Matsumura K, Watanabe Y, Kato K, Noyori R, Suzuki M, Watanabe Y (1996) A novel subtype of the prostaglandin receptor expressed in the central nervous system. J Biol Chem 271:5901-5906.
27. Theilen H, Kuschinsky W (1992) Fluorescence labeling of the capillary network in rat brain. J Cereb Blood Flow Metab 12:347-350.
28. Tilders FJH, DeRijk RH, van Dam A-M, Vincent VAM, Schotanus K, Persoons JHA (1994) Activation of the hypothalamus-pituitaryadrenal axis by bacterial endotoxins: routes and intermediate signals. Psychoneuroendocrinology 19:209-232.