A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

Brain, Behavior, and Immunity

Volumn 22, Issue 1, 2008, Pages 114-123

  Cui, Yu ^a   Liao, Xin Xue ^b   Liu, Wei ^a   Guo, Rui Xian ^a   Wu, Zhao Zhong ^c   Zhao, Chun Mei ^a   Chen, Pei Xi ^a   Feng, Jian Qiang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Microglia; Minocycline; Morphine; p38 MAPK; Tolerance

Indexed keywords

MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CELL ACTIVATION; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; MALE; MICROGLIA; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPINE;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; MALE; MICROGLIA; MINOCYCLINE; MORPHINE; NOCICEPTORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 36749098953     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2007.07.014     Document Type: Article

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