(+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats

Journal of Pain

Volumn 13, Issue 5, 2012, Pages 498-506

  Lewis, Susannah S ^a   Loram, Lisa C ^a   Hutchinson, Mark R ^b   Li, Chien Ming ^c   Zhang, Yingning ^a   Maier, Steven F ^a   Huang, Yong ^c   Rice, Kenner C ^d   Watkins, Linda R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c San Francisco   (United States)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

chronic constriction injury; HEK293 TLR4; neuropathic pain; spinal nerve ligation; TLR4

Indexed keywords

NALOXONE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL LINE; CHRONIC PAIN; CONTROLLED STUDY; DRUG HALF LIFE; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; NERVE INJURY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; REPORTER GENE; SIGNAL TRANSDUCTION; SPINAL NERVE;

ALKALINE PHOSPHATASE; ANALYSIS OF VARIANCE; ANIMALS; CELL LINE, TRANSFORMED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INJECTIONS, SUBCUTANEOUS; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; MALE; NALOXONE; NARCOTIC ANTAGONISTS; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TIME FACTORS; TOLL-LIKE RECEPTOR 4;

EID: 84860672423     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2012.02.005     Document Type: Article

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