Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells

Parasite Immunology

Volumn 29, Issue 3, 2007, Pages 127-137

  Goodridge, H S ^a   McGuiness, S ^a   Houston, K M ^b   Egan, C A ^b   Al Riyami, L ^b   Alcocer, M J C ^c   Harnett, M M ^a   Harnett, W ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Filarial nematode; Immunomodulation; Mannose receptor; Phosphorylcholine; Signalling; Toll like receptor

Indexed keywords

GLYCOPROTEIN; GLYCOPROTEIN EXCRETORY SECRETORY 62; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OVALBUMIN; PHOSPHORYLCHOLINE; PROLINE; PROTEIN KINASE B; RECOMBINANT EXCRETORY SECRETORY 62; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG CONJUGATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; DENDRITIC CELLS; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HELMINTH PROTEINS; INTERLEUKIN-12; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; OVALBUMIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLCHOLINE; PICHIA; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS); MUS; PICHIA PASTORIS;

EID: 33846921268     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2006.00926.x     Document Type: Article

References (38)

1. Allen JE & MacDonald AS. Profound suppression of cellular proliferation mediated by the secretions of nematodes. Parasite Immunol 1998; 20: 241-247.
2. Harnett W & Harnett MM. Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product. J Immunol 1993; 151: 4829-4837.
3. Deehan M, Harnett M & Harnett W. A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. J Immunol 1997; 159: 6105-6111.
4. Deehan MR, Frame MJ, Parkhouse RM et al. A phosphorylcholine- containing filarial nematode-secreted product disrupts B lymphocyte activation by targeting key proliferative signaling pathways. J Immunol 1998; 160: 2692-2699.
5. Harnett MM, Deehan MR, Williams DM & Harnett W. Induction of signalling anergy via the T-cell receptor in cultured Jurkat T cells by pre-exposure to a filarial nematode secreted product. Parasite Immunol 1998; 20: 551-563.
6. Harnett W, Deehan MD, Houston KM & Harnett MM. Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein. Parasite Immunol 1999; 21: 601-608.
7. Whelan M, Harnett MM, Houston KM, Patel V, Harnett W & Rigley KP. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J Immunol 2000; 164: 6453-6460.
8. Goodridge HS, Wilson EH, Harnett W, Campbell CC, Harnett MM & Liew FY. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J Immunol 2001; 167: 940-945.
9. Wilson EH, Katz E, Goodridge HS, Harnett M & Harnett W. In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62. Parasite Immunol 2003; 25: 463-466.
10. Wilson EH, Deehan MR, Katz E et al. Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo. Immunol 2003; 109: 238-245.
11. Harnett W, Goodridge HS & Harnett MM. Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitology 2005; 130 (Suppl. ): S63-S68.
12. Harnett MM & Harnett W. Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode. Arch Immunol Ther Exp (Warsz) 2001; 49: 263-269.
13. Houston K, Wilson EH, Eyres L et al. The presence of phosphorylcholine on a filarial nematode protein influences the IgG subclass response to a molecule and by a mechanism dependent on IL-10. Infect Immunity 2000; 68: 5466-5468.
14. McInnes IB, Leung BP, Harnett M, Gracie JA, Liew FY & Harnett W. A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. J Immunol 2003; 171: 2127-2133.
15. Marshall FA, Garside P, Harnett W & Harnett MM. ES-62, an immunomodulator secreted by filarial nematodes suppresses clonal expansion and skews effector function of heterologous antigen-specific T cells in vivo. J Immunol 2005; 175: 5817-5826.
16. Goodridge HS, Harnett W, Liew FY & Harnett MM. Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology 2003; 109: 415-425.
17. Goodridge HS, Marshall FA, Else KJ et al. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol 2005; 174: 284-293.
18. Goodridge HS, Marshall FA, Wilson EH et al. In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an antiinflammatory phenotype. Immunology 2004; 113: 491-498.
19. Babu S & Nutman TB. Proinflammatory cytokines dominate the early immune response to filarial parasites. J Immunol 2003; 171: 6723-6732.
20. Harnett W, Harnett MM & Byron O. Structural/functional aspects of ES-62 - a secreted immunomodulatory phosphorylcholinecontaining filarial nematode glycoprotein. Curr Protein Pept Sci 2003; 4: 59-71.
21. Goodridge HS, Deehan MR, Harnett W & Harnett MM. Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product. Cell Signal 2005; 17: 11-16.
22. Goodridge HS, Stepek G, Harnett W & Harnett MM. Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology 2005; 115: 296-304.
23. Egan CA, Houston KM, Alcocer MJ et al. Lack of immunological cross-reactivity between parasite-derived and recombinant forms of ES-62, a secreted protein of Acanthocheilonema viteae. Parasitology 2006; 132: 263-274.
24. Feng GJ, Goodridge HS, Harnett MM et al. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol 1999; 163: 6403-6412.
25. Walton KA, Cole AL, Yeh M et al. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol 2003; 23: 1197-1203.
26. Walton KA, Hsieh X, Gharavi N et al. Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine- mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. J Biol Chem 2003; 278: 29661-29666.
27. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN & Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem 2003; 278: 1561-1568.
28. Bluml S, Kirchberger S, Bochkov VN et al. Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40. J Immunol 2005; 175: 501-508.
29. Ma Z, Li J, Yang L et al. Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol 2004; 286: L808-L816.
30. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657.
31. Fukao T, Tanabe M, Terauchi Y et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 2002; 3: 875-881.
32. Guha M & Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002; 277: 32124-32132.
33. Martin M, Schifferle RE, Cuesta N, Vogel SN, Katz J & Michalek SM. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol 2003; 171: 717-725.
34. Zimmermann S & Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 1999; 286: 1741-1744.
35. Darveau RP, Pham TT, Lemley K et al. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun 2004; 72: 5041-5051.
36. Bainbridge BW, Coats SR & Darveau RP. Porphyromonas gingivalis lipopolysaccharide displays functionally diverse interactions with the innate host defense system. Ann Periodontol 2002; 7: 29-37.
37. Tse HM, Josephy SI, Chan ED, Fouts D & Cooper AM. Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages. J Immunol 2002; 168: 825-833.
38. Singh RP, Dhawan P, Golden C, Kapoor GS & Mehta KD. One-way cross-talk between p38 (MAPK) and p42/44 (MAPK). Inhibition of p38 (MAPK) induces low density lipoprotein receptor expression through activation of the p42/44 (MAPK) cascade. J Biol Chem 1999; 274: 19593-19600.