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Volumn 87, Issue 1035, 2014, Pages

Defining normoxia, physoxia and hypoxia in tumours - Implications for treatment response

Author keywords

[No Author keywords available]

Indexed keywords

BANOXANTRONE; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR; OXYGEN; TIRAPAZAMINE;

EID: 84908267762     PISSN: 00071285     EISSN: 1748880X     Source Type: Journal    
DOI: 10.1259/bjr.20130676     Document Type: Review
Times cited : (713)

References (126)
  • 1
    • 84960987950 scopus 로고
    • Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC. Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953; 26: 638-48.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 2
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1995; 9: 539-49.
    • (1995) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 3
    • 0003605672 scopus 로고    scopus 로고
    • Philadelphia PA: Wolters Kluwer Health/Lippincott Williams & Wilkins;
    • Hall EJ, Giaccia A. Radiobiology for the radiologist. Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012.
    • (2012) Radiobiology for the Radiologist
    • Hall, E.J.1    Giaccia, A.2
  • 4
    • 33751543273 scopus 로고    scopus 로고
    • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    • Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol 2006; 82: 699-757. doi: 10.1080/09553000601002324
    • (2006) Int J Radiat Biol , vol.82 , pp. 699-757
    • Tatum, J.L.1    Kelloff, G.J.2    Gillies, R.J.3    Arbeit, J.M.4    Brown, J.M.5    Chao, K.S.6
  • 5
    • 34447506424 scopus 로고    scopus 로고
    • Detection and characterization of tumor hypoxia using pO2 histography
    • Vaupel P, Höckel M, Mayer A. Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 2007; 9: 1221-35. doi: 10.1089/ars.2007.1628
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1221-1235
    • Vaupel, P.1    Höckel, M.2    Mayer, A.3
  • 6
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxiamediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, et al. Hypoxiamediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996; 379: 88-91. doi: 10.1038/379088a0
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6
  • 7
    • 77957746194 scopus 로고    scopus 로고
    • Metabolic microenvironment of tumor cells: A key factor in malignant progression
    • Vaupel P. Metabolic microenvironment of tumor cells: a key factor in malignant progression. Exp Oncol 2010; 32: 125-7.
    • (2010) Exp Oncol , vol.32 , pp. 125-127
    • Vaupel, P.1
  • 8
    • 79954579633 scopus 로고    scopus 로고
    • EMT: A new vision of hypoxia promoting cancer progression
    • Jiang J, Tang YL, Liang XH. EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol Ther 2011; 11: 714-23.
    • (2011) Cancer Biol Ther , vol.11 , pp. 714-723
    • Jiang, J.1    Tang, Y.L.2    Liang, X.H.3
  • 9
    • 0028307739 scopus 로고
    • Hypoxia and drug resistance
    • Teicher BA. Hypoxia and drug resistance. Cancer Metastasis Rev 1994; 13: 139-68.
    • (1994) Cancer Metastasis Rev , vol.13 , pp. 139-168
    • Teicher, B.A.1
  • 10
  • 11
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 2011; 11: 393-410. doi: 10.1038/nrc3064
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 12
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Höckel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001; 93: 266-76.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 13
    • 79957635293 scopus 로고    scopus 로고
    • Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
    • doi:10.1111/j.1582-4934.2011.01258.x
    • Carreau A, El Hafny-Rahbi B, Matejuk A, Grillon C, Kieda C. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med 2011; 15: 1239-53. doi:10.1111/j.1582-4934.2011.01258.x
    • (2011) J Cell Mol Med , vol.15 , pp. 1239-1253
    • Carreau, A.1    El Hafny-Rahbi, B.2    Matejuk, A.3    Grillon, C.4    Kieda, C.5
  • 14
    • 0028242772 scopus 로고
    • Measurement of human tumour oxygenation status by a polarographic needle electrode
    • Nordsmark M, Bentzen SM, Overgaard J. Measurement of human tumour oxygenation status by a polarographic needle electrode. Acta Oncol 1994; 33: 383-9.
    • (1994) Acta Oncol , vol.33 , pp. 383-389
    • Nordsmark, M.1    Bentzen, S.M.2    Overgaard, J.3
  • 15
    • 0344936018 scopus 로고    scopus 로고
    • Oxygenation of squamous cell carcinoma of the head and neck: Comparison of primary tumors, neck node metastases, and normal tissue
    • Becker A, Hänsgen G, Bloching M, Weigel C, Lautenschläger C, Dunst J. Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue. Int J Radiat Oncol Biol Phys 1998; 42: 35-41.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 35-41
    • Becker, A.1    Hänsgen, G.2    Bloching, M.3    Weigel, C.4    Lautenschläger, C.5    Dunst, J.6
  • 16
    • 0037963317 scopus 로고    scopus 로고
    • Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients
    • Le QT, Kovacs MS, Dorie MJ, Koong A, Terris DJ, Pinto HA, et al. Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2003; 56: 375-83.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 375-383
    • Le Kovacs, Q.T.M.S.1    Dorie, M.J.2    Koong, A.3    Terris, D.J.4    Pinto, H.A.5
  • 17
    • 0026448918 scopus 로고
    • The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised pO2 histography
    • Falk SJ,Ward R, Bleehen NM. The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised pO2 histography. Br J Cancer 1992; 66: 919-24.
    • (1992) Br J Cancer , vol.66 , pp. 919-924
    • Falk Sjward, R.1    Bleehen, N.M.2
  • 18
    • 33645079888 scopus 로고    scopus 로고
    • Et al An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    • doi:10.1158/1078-0432.CCR-05-2049
    • Le QT, Chen E, Salim A, Cao H, Kong CS, Whyte R, et al An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res 2006; 12: 1507-14. doi:10.1158/1078-0432.CCR-05-2049
    • (2006) Clin Cancer Res , vol.12 , pp. 1507-1514
    • Le Chen, Q.T.E.1    Salim, A.2    Cao, H.3    Kong, C.S.4    Whyte, R.5
  • 19
    • 0345707572 scopus 로고    scopus 로고
    • Oxygenation gain factor: A novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers
    • Vaupel P, Mayer A, Briest S, Höckel M. Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 2003; 63: 7634-7.
    • (2003) Cancer Res , vol.63 , pp. 7634-7637
    • Vaupel, P.1    Mayer, A.2    Briest, S.3    Höckel, M.4
  • 20
    • 0026356726 scopus 로고
    • Oxygenation of carcinomas of the uterine cervix: Evaluation by computerized O2 tension measurements
    • Höckel M, Schlenger K, Knoop C, Vaupel P. Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Res 1991; 51: 6098-102.
    • (1991) Cancer Res , vol.51 , pp. 6098-6102
    • Höckel, M.1    Schlenger, K.2    Knoop, C.3    Vaupel, P.4
  • 21
    • 8544247188 scopus 로고
    • Can the oxygenation status of rectal carcinomas be improved by hypoxia?
    • Vaupel P, Kelleher DK, Günderoth M, eds. Stuttgart, Germany: Gustav Fischer
    • Kallinowski F, Buhr HJ. Can the oxygenation status of rectal carcinomas be improved by hypoxia? In: Vaupel P, Kelleher DK, Günderoth M, eds. Tumor oxygenation. Stuttgart, Germany: Gustav Fischer; 1995. pp. 291-6.
    • (1995) Tumor Oxygenation , pp. 291-296
    • Kallinowski, F.1    Buhr, H.J.2
  • 22
    • 0000276364 scopus 로고
    • Tissue oxygenation of primary, metastatic and xenografted rectal cancers
    • Vaupel P, Kelleher DK, Günderoth M, eds. Stuttgart, Germany: Gustav Fischer
    • Kallinowski F, Buhr HJ. Tissue oxygenation of primary, metastatic and xenografted rectal cancers. In: Vaupel P, Kelleher DK, Günderoth M, eds. Tumor oxygenation. Stuttgart, Germany: Gustav Fischer; 1995. pp. 205-9.
    • (1995) Tumor Oxygenation , pp. 205-209
    • Kallinowski, F.1    Buhr, H.J.2
  • 24
    • 0034745063 scopus 로고    scopus 로고
    • Polarographic pO2 measurements of intraabdominal adenocarcinoma in connection with intraoperative radiotherapy before and after change of oxygen concentration of anaesthetic gases
    • Graffman S, Björk P, Ederoth P, Ihse I. Polarographic pO2 measurements of intraabdominal adenocarcinoma in connection with intraoperative radiotherapy before and after change of oxygen concentration of anaesthetic gases. Acta Oncol 2001; 40: 105-7.
    • (2001) Acta Oncol , vol.40 , pp. 105-107
    • Graffman, S.1    Björk, P.2    Ederoth, P.3    Ihse, I.4
  • 26
    • 10744221495 scopus 로고    scopus 로고
    • Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer
    • doi:10.1016/S0360-3016(03)01621-3
    • Parker C, Milosevic M, Toi A, Sweet J, Panzarella T, Bristow R, et al. Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 2004; 58: 750-7. doi:10.1016/S0360-3016(03)01621-3
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 750-757
    • Parker, C.1    Milosevic, M.2    Toi, A.3    Sweet, J.4    Panzarella, T.5    Bristow, R.6
  • 28
    • 0036904009 scopus 로고    scopus 로고
    • Oxygenation status of gynecologic tumors: What is the optimal hemoglobin level?
    • Vaupel P, Thews O, Mayer A, Höckel S, Höckel M. Oxygenation status of gynecologic tumors: what is the optimal hemoglobin level? Strahlenther Onkol 2002; 178: 727-31. doi: 10.1007/s00066-002-1081-x
    • (2002) Strahlenther Onkol , vol.178 , pp. 727-731
    • Vaupel, P.1    Thews, O.2    Mayer, A.3    Höckel, S.4    Höckel, M.5
  • 29
    • 33645970387 scopus 로고    scopus 로고
    • Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva
    • Vaupel P, Mayer A, Höckel M. Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva. Eur J Gynaecol Oncol 2006; 27: 142-6.
    • (2006) Eur J Gynaecol Oncol , vol.27 , pp. 142-146
    • Vaupel, P.1    Mayer, A.2    Höckel, M.3
  • 30
    • 14644437020 scopus 로고    scopus 로고
    • Intratumoral oxygenation of invasive squamous cell carcinoma of the vulva is not correlated with regional lymph node metastasis
    • Stone JE, Parker R, Gilks CB, Stanbridge EJ, Liao SY, Aquino-Parsons C. Intratumoral oxygenation of invasive squamous cell carcinoma of the vulva is not correlated with regional lymph node metastasis. Eur J Gynaecol Oncol 2005; 26: 31-5.
    • (2005) Eur J Gynaecol Oncol , vol.26 , pp. 31-35
    • Stone, J.E.1    Parker, R.2    Gilks, C.B.3    Stanbridge, E.J.4    Liao, S.Y.5    Aquino-Parsons, C.6
  • 32
    • 24044503731 scopus 로고    scopus 로고
    • Assessing regional hypoxia in human renal tumours using 18F-fluoromisonidazolepositron emission tomography
    • Lawrentschuk N, Poon AM, Foo SS, Putra LG, Murone C, Davis ID, et al. Assessing regional hypoxia in human renal tumours using 18F-fluoromisonidazolepositron emission tomography. BJU Int 2005; 96: 540-6. doi: 10.1111/j.1464-410X.2005.05681.x
    • (2005) BJU Int , vol.96 , pp. 540-546
    • Lawrentschuk, N.1    Poon, A.M.2    Foo, S.S.3    Putra, L.G.4    Murone, C.5    Davis, I.D.6
  • 33
    • 0030037148 scopus 로고    scopus 로고
    • Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
    • Mattern J, Kallinowski F, Herfarth C, Volm M. Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer. Int J Cancer 1996; 67: 20-3. doi: 10.1002/(SICI)1097-0215(19960703)67:1,20::AIDIJC5.3.0.CO;2-1
    • (1996) Int J Cancer , vol.67 , pp. 20-23
    • Mattern, J.1    Kallinowski, F.2    Herfarth, C.3    Volm, M.4
  • 34
    • 84873463368 scopus 로고    scopus 로고
    • Oxygen: The poison is in the dose
    • doi:10.1111/j.1537-2995.2012.03774.x
    • Winslow RM. Oxygen: the poison is in the dose. Transfusion 2013; 53: 424-37. doi:10.1111/j.1537-2995.2012.03774.x
    • (2013) Transfusion , vol.53 , pp. 424-437
    • Winslow, R.M.1
  • 35
    • 0034786029 scopus 로고    scopus 로고
    • Limitations to oxygen diffusion and equilibration in in vitro cell exposure systems in hyperoxia and hypoxia
    • Allen CB, Schneider BK, White CW. Limitations to oxygen diffusion and equilibration in in vitro cell exposure systems in hyperoxia and hypoxia. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1021-7.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L1021-L1027
    • Allen, C.B.1    Schneider, B.K.2    White, C.W.3
  • 36
    • 0032517494 scopus 로고    scopus 로고
    • Oxygen transport- 2. Tissue hypoxia
    • Leach RM, Treacher DF. Oxygen transport- 2. Tissue hypoxia. BMJ 1998; 317: 1370-3.
    • (1998) BMJ , vol.317 , pp. 1370-1373
    • Leach, R.M.1    Treacher, D.F.2
  • 37
    • 79951807773 scopus 로고    scopus 로고
    • Hypoxiamediated biological control
    • Cassavaugh J, Lounsbury KM. Hypoxiamediated biological control. J Cell Biochem 2011; 112: 735-44. doi: 10.1002/jcb.22956
    • (2011) J Cell Biochem , vol.112 , pp. 735-744
    • Cassavaugh, J.1    Lounsbury, K.M.2
  • 38
    • 0029859510 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
    • Jiang BH, Semenza GL, Bauer C, Marti HH. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 1996; 271: C1172-80.
    • (1996) Am J Physiol , vol.271 , pp. C1172-C1180
    • Jiang, B.H.1    Semenza, G.L.2    Bauer, C.3    Marti, H.H.4
  • 39
    • 77952538743 scopus 로고    scopus 로고
    • Tumor angiogenesis: Insights and innovations
    • Apr, Epub ahead of print
    • Nussenbaum F, Herman IM. Tumor angiogenesis: insights and innovations. J Oncol Apr 2010. Epub ahead of print. doi: 10.1155/2010/132641
    • (2010) J Oncol
    • Nussenbaum, F.1    Herman, I.M.2
  • 40
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxiainducible factors in tumorigenesis
    • Rankin EB, Giaccia AJ. The role of hypoxiainducible factors in tumorigenesis. Cell Death Differ 2008; 15: 678-85. doi: 10.1038/cdd.2008.21
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 41
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-14.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 42
    • 17144416875 scopus 로고    scopus 로고
    • Anoxia is necessary for tumor cell toxicity caused by a lowoxygen environment
    • Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a lowoxygen environment. Cancer Res 2005; 65: 3171-8. doi: 10.1158/0008-5472.CAN-04-3395
    • (2005) Cancer Res , vol.65 , pp. 3171-3178
    • Papandreou, I.1    Krishna, C.2    Kaper, F.3    Cai, D.4    Giaccia, A.J.5    Denko, N.C.6
  • 43
    • 47049091483 scopus 로고    scopus 로고
    • Hypoxia selects for invasive, androgen independent and apoptosis-resistant LNCaP cells in vitro
    • Butterworth KT, McCarthy HO, Devlin A, Ming L, Robson T, McKeown SR, et al. Hypoxia selects for invasive, androgen independent and apoptosis-resistant LNCaP cells in vitro. Int J Cancer 2008; 123: 760-8. doi: 10.1002/ijc.23418
    • (2008) Int J Cancer , vol.123 , pp. 760-768
    • Butterworth, K.T.1    McCarthy, H.O.2    Devlin, A.3    Ming, L.4    Robson, T.5    McKeown, S.R.6
  • 44
    • 84872968566 scopus 로고    scopus 로고
    • Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: Informed scheduling of the bioreductive drug AQ4N improves treatment response
    • Ming L, Byrne NM, Camac SN, Mitchell CA, Ward C, Waugh DJ, et al. Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response. Int J Cancer 2013; 132: 1323-32.
    • (2013) Int J Cancer , vol.132 , pp. 1323-1332
    • Ming, L.1    Byrne, N.M.2    Camac, S.N.3    Mitchell, C.A.4    Ward, C.5    Waugh, D.J.6
  • 45
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer 2012; 12: 487-93. doi: 10.1038/nrc3298
    • (2012) Nat Rev Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 46
    • 1642565876 scopus 로고    scopus 로고
    • Tumor hypoxia and malignant progression
    • Vaupel P, Mayer A, Höckel M. Tumor hypoxia and malignant progression. Methods Enzymol 2004; 381: 335-54. doi: 10.1016/S0076-6879(04)81023-1
    • (2004) Methods Enzymol , vol.381 , pp. 335-354
    • Vaupel, P.1    Mayer, A.2    Höckel, M.3
  • 47
    • 33644506104 scopus 로고    scopus 로고
    • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor
    • Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res 2006; 66: 2219-23.
    • (2006) Cancer Res , vol.66 , pp. 2219-2223
    • Lanzen, J.1    Braun, R.D.2    Klitzman, B.3    Brizel, D.4    Secomb, T.W.5    Dewhirst, M.W.6
  • 48
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia HIF1 and glucose metabolism in the solid tumour
    • Denko N. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008; 8: 705-13. doi: 10.1038/nrc2468
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.1
  • 49
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer. 2002; 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 50
    • 0026563228 scopus 로고
    • Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probe
    • Olive PL, Vikse C, Trotter MJ. Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probe. Int J Radiat Oncol Biol Phys 1992; 22: 397-402.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 397-402
    • Olive, P.L.1    Vikse, C.2    Trotter, M.J.3
  • 51
    • 1642536758 scopus 로고
    • Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice
    • Torres-Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc Natl Acad Sci U S A 1994; 91: 2081-5.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 2081-2085
    • Torres-Filho, I.P.1    Leunig, M.2    Yuan, F.3    Intaglietta, M.4    Jain, R.K.5
  • 52
    • 0026011102 scopus 로고
    • Drug induced perturbations in tumour blood flow: Therapeutic potential and possible limitations
    • Chaplin DJ, Peters CE, Horsman MR, Trotter MJ. Drug induced perturbations in tumour blood flow: therapeutic potential and possible limitations. Radiother Oncol 1991; 20(Suppl. 1): 93-101.
    • (1991) Radiother Oncol , vol.20 , pp. 93-101
    • Chaplin, D.J.1    Peters, C.E.2    Horsman, M.R.3    Trotter, M.J.4
  • 53
    • 70549102512 scopus 로고    scopus 로고
    • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    • Dewhirst MW. Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 2009; 172: 653-65.
    • (2009) Radiat Res , vol.172 , pp. 653-665
    • Dewhirst, M.W.1
  • 54
    • 84862695530 scopus 로고    scopus 로고
    • Acute versus chronic hypoxia in tumors: Controversial data concerning time frames and biological consequences
    • Bayer C, Vaupel P. Acute versus chronic hypoxia in tumors: controversial data concerning time frames and biological consequences. Strahlenther Onkol 2012; 188: 616-27. doi: 10.1007/s00066-012-0085-4
    • (2012) Strahlenther Onkol , vol.188 , pp. 616-627
    • Bayer, C.1    Vaupel, P.2
  • 55
    • 1542405875 scopus 로고    scopus 로고
    • Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    • Cairns RA, Hill RP. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res 2004; 64: 2054-61.
    • (2004) Cancer Res , vol.64 , pp. 2054-2061
    • Cairns, R.A.1    Hill, R.P.2
  • 56
    • 0035893396 scopus 로고    scopus 로고
    • Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors
    • Cairns RA, Kalliomaki T, Hill RP. Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 2001; 61: 8903-8.
    • (2001) Cancer Res , vol.61 , pp. 8903-8908
    • Cairns, R.A.1    Kalliomaki, T.2    Hill, R.P.3
  • 57
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis
    • doi:10.1634/theoncologist.13-S3-21
    • Vaupel P. Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist 2008; 13: 21-6. doi:10.1634/theoncologist.13-S3-21
    • (2008) Oncologist , vol.13 , pp. 21-26
    • Vaupel, P.1
  • 58
    • 56149089262 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and cancer pathogenesis
    • Semenza GL. Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life 2008; 60: 591-7. doi: 10.1002/iub.93
    • (2008) IUBMB Life , vol.60 , pp. 591-597
    • Semenza, G.L.1
  • 59
    • 84865575592 scopus 로고    scopus 로고
    • Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
    • doi:10.1016/j.molmed.2012.08.001
    • Semenza GL. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends Mol Med 2012; 18: 534-43. doi:10.1016/j.molmed.2012.08.001
    • (2012) Trends Mol Med , vol.18 , pp. 534-543
    • Semenza, G.L.1
  • 60
    • 84883501150 scopus 로고    scopus 로고
    • HIF1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • Semenza GL. HIF1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest 2013; 123: 3664-71. doi: 10.1172/JCI67230
    • (2013) J Clin Invest , vol.123 , pp. 3664-3671
    • Semenza, G.L.1
  • 61
    • 84870941135 scopus 로고    scopus 로고
    • Hypoxia-regulated target genes implicated in tumor metastasis
    • Tsai YP, Wu KJ. Hypoxia-regulated target genes implicated in tumor metastasis. J Biomed Sci 2012; 19: 102. doi: 10.1186/1423-0127-19-102
    • (2012) J Biomed Sci , vol.19 , pp. 102
    • Tsai, Y.P.1    Wu, K.J.2
  • 62
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signaling through mTOR and the unfolded protein response in cancer
    • Wouters BG, Koritzinsky M. Hypoxia signaling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 2008; 8: 851-64. doi: 10.1038/nrc2501
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 63
    • 32544458522 scopus 로고    scopus 로고
    • Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors
    • Koshikawa N, Maejima C, Miyazaki K, Nakagawara A, Takenaga K. Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors. Oncogene 2006; 25: 917-28. doi: 10.1038/sj.onc.1209128
    • (2006) Oncogene , vol.25 , pp. 917-928
    • Koshikawa, N.1    Maejima, C.2    Miyazaki, K.3    Nakagawara, A.4    Takenaga, K.5
  • 64
    • 10044277941 scopus 로고    scopus 로고
    • Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways
    • Weinmann M, Jendrossek V, Güner D, Goecke B, Belka C. Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways. FASEB J 2004; 18: 1906-18. doi: 10.1096/fj.04-1918fje
    • (2004) FASEB J , vol.18 , pp. 1906-1918
    • Weinmann, M.1    Jendrossek, V.2    Güner, D.3    Goecke, B.4    Belka, C.5
  • 65
    • 0025253789 scopus 로고
    • Effects of reoxygenation on cells from hypoxic regions of solid tumors: Anticancer drug sensitivity and metastatic potential
    • Young SD, Hill RP. Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential. J Natl Cancer Inst 1990; 82: 371-80.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 371-380
    • Young, S.D.1    Hill, R.P.2
  • 66
    • 0010170555 scopus 로고    scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young SD, Marshall RS, Hill RP. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A.1998; 85: 9533-7.
    • (1998) Proc Natl Acad Sci U S A , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 67
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia DNA repair and genetic instability
    • Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008; 8: 180-92. doi: 10.1038/nrc2344
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 68
    • 0034037286 scopus 로고    scopus 로고
    • Microenvironment-induced cancer metastasis
    • Rofstad EK. Microenvironment-induced cancer metastasis. Int J Radiat Biol 2000; 76: 589-605.
    • (2000) Int J Radiat Biol , vol.76 , pp. 589-605
    • Rofstad, E.K.1
  • 69
  • 70
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 2007; 26: 333-9. doi: 10.1007/s10555-007-9063-1
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 71
    • 3042616216 scopus 로고    scopus 로고
    • Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis
    • Zhang L, Hill RP. Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res 2004; 64: 4180-9. doi: 10.1158/0008-5472.CAN-03-3038
    • (2004) Cancer Res , vol.64 , pp. 4180-4189
    • Zhang, L.1    Hill, R.P.2
  • 72
    • 34548011229 scopus 로고    scopus 로고
    • Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion
    • Zhang L, Hill RP. Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. Cancer Res 2007; 67: 7789-97. doi: 10.1158/0008-5472.CAN-06-4221
    • (2007) Cancer Res , vol.67 , pp. 7789-7797
    • Zhang, L.1    Hill, R.P.2
  • 73
    • 84860294684 scopus 로고    scopus 로고
    • Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
    • Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, et al. Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun 2012; 3: 783. doi: 10.1038/ncomms1786.
    • (2012) Nat Commun , vol.3 , pp. 783
    • Harada, H.1    Inoue, M.2    Itasaka, S.3    Hirota, K.4    Morinibu, A.5    Shinomiya, K.6
  • 74
    • 0037279517 scopus 로고    scopus 로고
    • The hypoxic tumour microenvironment and metastatic progression
    • Subarsky P, Hill RP. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 2003; 20: 237-50.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 237-250
    • Subarsky, P.1    Hill, R.P.2
  • 75
    • 77956619068 scopus 로고    scopus 로고
    • Tumour-microenvironmental interactions: Paths to progression and targets for treatment
    • Box C, Rogers SJ, Mendiola M, Eccles SA. Tumour-microenvironmental interactions: paths to progression and targets for treatment. Semin Cancer Biol 2010; 20: 128-38. doi: 10.1016/j.semcancer.2010.06.004
    • (2010) Semin Cancer Biol , vol.20 , pp. 128-138
    • Box, C.1    Rogers, S.J.2    Mendiola, M.3    Eccles, S.A.4
  • 76
    • 79955971818 scopus 로고    scopus 로고
    • Tumor hypoxia and genetic alterations in sporadic cancers
    • Koi M, Boland CR. Tumor hypoxia and genetic alterations in sporadic cancers. J Obstet Gynaecol Res 2011; 37: 85-98. doi: 10.1111/j.1447-0756.2010.01377.x
    • (2011) J Obstet Gynaecol Res , vol.37 , pp. 85-98
    • Koi, M.1    Boland, C.R.2
  • 77
    • 84872391385 scopus 로고    scopus 로고
    • The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man
    • Sharma NL, Massie CE, Ramos-Montoya A, Zecchini V, Scott HE, Lamb AD, et al. The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man. Cancer Cell 2013; 23: 35-47. doi: 10.1016/j.ccr.2012.11.010
    • (2013) Cancer Cell , vol.23 , pp. 35-47
    • Sharma, N.L.1    Massie, C.E.2    Ramos-Montoya, A.3    Zecchini, V.4    Scott, H.E.5    Lamb, A.D.6
  • 78
    • 84886675563 scopus 로고    scopus 로고
    • Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease
    • Goel S, Wong AH, Jain RK. Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harb Perspect Med 2012; 2: a006486. doi: 10.1101/cshperspect.a006486
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006486
    • Goel, S.1    Wong, A.H.2    Jain, R.K.3
  • 79
    • 79954582454 scopus 로고    scopus 로고
    • Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
    • Chang Q, Jurisica I, Do T, Hedley DW. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res 2011; 71: 3110-20. doi: 10.1158/0008-5472.CAN-10-4049
    • (2011) Cancer Res , vol.71 , pp. 3110-3120
    • Chang, Q.1    Jurisica, I.2    Do, T.3    Hedley, D.W.4
  • 81
    • 79957529403 scopus 로고    scopus 로고
    • Novel angiogenesis inhibitors: Addressing the issue of redundancy in the angiogenic signaling pathway
    • Ribatti D. Novel angiogenesis inhibitors: addressing the issue of redundancy in the angiogenic signaling pathway. Cancer Treat Rev 2011; 37: 344-52. doi: 10.1016/j.ctrv.2011.02.002
    • (2011) Cancer Treat Rev , vol.37 , pp. 344-352
    • Ribatti, D.1
  • 82
    • 57449083765 scopus 로고    scopus 로고
    • Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer
    • Wilson C, Scullin P, Worthington J, Seaton A, Maxwell P, O'Rourke D, et al. Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer. Br J Cancer 2008; 99: 2054-64. doi: 10.1038/sj.bjc.6604804
    • (2008) Br J Cancer , vol.99 , pp. 2054-2064
    • Wilson, C.1    Scullin, P.2    Worthington, J.3    Seaton, A.4    Maxwell, P.5    O'rourke, D.6
  • 83
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • doi:10.1016/j.ccr.2009.01.021
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15: 232-9. doi:10.1016/j.ccr.2009.01.021
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 84
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Viñals F, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15: 220-31. doi: 10.1016/j.ccr.2009.01.027
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Pàez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Viñals, F.6
  • 86
    • 54049122927 scopus 로고    scopus 로고
    • The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer
    • Rajaganeshan R, Prasad R, Guillou PJ, Poston G, Scott N, Jayne DG. The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer. Int J Colorectal Dis 2008; 23: 1049-55. doi: 10.1007/s00384-008-0497-x
    • (2008) Int J Colorectal Dis , vol.23 , pp. 1049-1055
    • Rajaganeshan, R.1    Prasad, R.2    Guillou, P.J.3    Poston, G.4    Scott, N.5    Jayne, D.G.6
  • 87
    • 0034331255 scopus 로고    scopus 로고
    • Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age: An Eppendorf pO(2) study
    • Movsas B, Chapman JD, Greenberg RE, Hanlon AL, Horwitz EM, Pinover WH, et al. Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age: an Eppendorf pO(2) study. Cancer 2000; 89: 2018-24.
    • (2000) Cancer , vol.89 , pp. 2018-2024
    • Movsas, B.1    Chapman, J.D.2    Greenberg, R.E.3    Hanlon, A.L.4    Horwitz, E.M.5    Pinover, W.H.6
  • 88
    • 84859408670 scopus 로고    scopus 로고
    • Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer
    • Milosevic M, Warde P, Ménard C, Chung P, Toi A, Ishkanian A, et al Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer. Clin Cancer Res 2012; 18: 2108-14. doi: 10.1158/1078-0432.CCR-11-2711
    • (2012) Clin Cancer Res , vol.18 , pp. 2108-2114
    • Milosevic, M.1    Warde, P.2    Ménard, C.3    Chung, P.4    Toi, A.5    Ishkanian, A.6
  • 89
    • 0036775108 scopus 로고    scopus 로고
    • Hypoxic prostate/muscle pO2 ratio predicts for biochemical failure in patients with prostate cancer: Preliminary findings
    • Movsas B, Chapman JD, Hanlon AL, Horwitz EM, Greenberg RE, Stobbe C, et al. Hypoxic prostate/muscle pO2 ratio predicts for biochemical failure in patients with prostate cancer: preliminary findings. Urology 2002; 60: 634-9.
    • (2002) Urology , vol.60 , pp. 634-639
    • Movsas, B.1    Chapman, J.D.2    Hanlon, A.L.3    Horwitz, E.M.4    Greenberg, R.E.5    Stobbe, C.6
  • 90
    • 84856405075 scopus 로고    scopus 로고
    • Hypoxic prostate/muscle PO2 ratio predicts for outcome in patients with localized prostate cancer: Long-term results
    • Turaka A, Buyyounouski MK, Hanlon AL, Horwitz EM, Greenberg RE, Movsas B. Hypoxic prostate/muscle PO2 ratio predicts for outcome in patients with localized prostate cancer: long-term results. Int J Radiat Oncol Biol Phys 2012; 82: e433-9. doi: 10.1016/j.ijrobp.2011.05.037
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. e433-e439
    • Turaka, A.1    Buyyounouski, M.K.2    Hanlon, A.L.3    Horwitz, E.M.4    Greenberg, R.E.5    Movsas, B.6
  • 91
    • 84866635520 scopus 로고    scopus 로고
    • Hypoxiamediated regulation of stem cell fate
    • Singh RP, Franke K, Wielockx B. Hypoxiamediated regulation of stem cell fate. High Alt Med Biol 2012; 13: 162-8. doi: 10.1089/ham.2012.1043
    • (2012) High Alt Med Biol , vol.13 , pp. 162-168
    • Singh, R.P.1    Franke, K.2    Wielockx, B.3
  • 92
    • 84874976801 scopus 로고    scopus 로고
    • A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy
    • Mao Q, Zhang Y, Fu X, Xue J, Guo W, Meng M, et al. A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy. J Cancer Res Clin Oncol 2013; 139: 211-22. doi: 10.1007/s00432-012-1310-3
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 211-222
    • Mao, Q.1    Zhang, Y.2    Fu, X.3    Xue, J.4    Guo, W.5    Meng, M.6
  • 93
    • 62149108987 scopus 로고    scopus 로고
    • Hypoxia or in situ normoxia: The stem cell paradigm
    • Ivanovic Z. Hypoxia or in situ normoxia: the stem cell paradigm. J Cell Physiol 2009; 219: 271-5. doi: 10.1002/jcp.21690
    • (2009) J Cell Physiol , vol.219 , pp. 271-275
    • Ivanovic, Z.1
  • 94
    • 84887161959 scopus 로고    scopus 로고
    • Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia
    • Marie-Egyptienne DT, Lohse I, Hill RP. Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia. Cancer Lett 2013; 341: 63-72. doi: 10.1016/j.canlet.2012.11.019
    • (2013) Cancer Lett , vol.341 , pp. 63-72
    • Marie-Egyptienne, D.T.1    Lohse, I.2    Hill, R.P.3
  • 95
    • 82655162024 scopus 로고    scopus 로고
    • Hypoxia, stem cells and bone tumor
    • Zeng W, Wan R, Zheng Y, Singh SR, Wei Y. Hypoxia, stem cells and bone tumor. Cancer Lett 2011; 313: 129-36. doi: 10.1016/j.canlet.2011.09.023
    • (2011) Cancer Lett , vol.313 , pp. 129-136
    • Zeng, W.1    Wan, R.2    Zheng, Y.3    Singh, S.R.4    Wei, Y.5
  • 96
    • 84862776944 scopus 로고    scopus 로고
    • From stem cells to cancer stem cells: HIF takes the stage
    • doi:10.1016/j.ceb.2012.01.005
    • Lee EK, Simon MC. From stem cells to cancer stem cells: HIF takes the stage. Curr Opin Cell Biol 2012; 24: 232-5. doi:10.1016/j.ceb.2012.01.005
    • (2012) Curr Opin Cell Biol , vol.24 , pp. 232-235
    • Lee, E.K.1    Simon, M.C.2
  • 98
    • 24644441655 scopus 로고    scopus 로고
    • The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines
    • doi:10.1002/cncr.21324
    • Delaney G, Jacob S, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005; 104: 1129-37. doi:10.1002/cncr.21324
    • (2005) Cancer , vol.104 , pp. 1129-1137
    • Delaney, G.1    Jacob, S.2    Featherstone, C.3    Barton, M.4
  • 99
    • 26444467146 scopus 로고    scopus 로고
    • Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: Results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    • Overgaard J, Eriksen JG, Nordsmark M, Alsner J, Horsman MR; Danish Head and Neck Cancer Study Group. Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol 2005; 6: 757-64.
    • (2005) Lancet Oncol , vol.6 , pp. 757-764
    • Overgaard, J.1    Eriksen, J.G.2    Nordsmark, M.3    Alsner, J.4    Horsman, M.R.5
  • 100
    • 34748860952 scopus 로고    scopus 로고
    • Hypoxic radiosensitization: Adored and ignored
    • Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol 2007; 25: 4066-74. doi: 10.1200/JCO.2007.12.7878
    • (2007) J Clin Oncol , vol.25 , pp. 4066-4074
    • Overgaard, J.1
  • 101
    • 84866034901 scopus 로고    scopus 로고
    • Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy
    • Jordan BF, Sonveaux P. Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy. Front Pharmacol 2012; 3: 94. doi: 10.3389/fphar.2012.00094
    • (2012) Front Pharmacol , vol.3 , pp. 94
    • Jordan, B.F.1    Sonveaux, P.2
  • 102
    • 53649095183 scopus 로고    scopus 로고
    • Hyperbaric oxygenation for tumour sensitisation to radiotherapy: A systematic review of randomised controlled trials
    • Bennett M, Feldmeier J, Smee R, Milross C. Hyperbaric oxygenation for tumour sensitisation to radiotherapy: a systematic review of randomised controlled trials. Cancer Treat Rev 2008; 34: 577-91. doi: 10.1016/j.ctrv.2008.01.001
    • (2008) Cancer Treat Rev , vol.34 , pp. 577-591
    • Bennett, M.1    Feldmeier, J.2    Smee, R.3    Milross, C.4
  • 103
    • 0142186283 scopus 로고    scopus 로고
    • Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial
    • Henke M, Laszig R, Rübe C, Schäfer U, Haase KD, Schilcher B, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362: 1255-60.
    • (2003) Lancet , vol.362 , pp. 1255-1260
    • Henke, M.1    Laszig, R.2    Rübe, C.3    Schäfer, U.4    Haase, K.D.5    Schilcher, B.6
  • 104
    • 35448992197 scopus 로고    scopus 로고
    • Radiotherapy with or without erythropoietin for anemic patients with head and neck cancer: A randomized trial of the Radiation Therapy Oncology Group (RTOG 99-03)
    • Machtay M, Pajak TF, Suntharalingam M, Shenouda G, Hershock D, Stripp DC, et al. Radiotherapy with or without erythropoietin for anemic patients with head and neck cancer: a randomized trial of the Radiation Therapy Oncology Group (RTOG 99-03). Int J Radiat Oncol Biol Phys 2007; 69: 1008-17. doi: 10.1016/j.ijrobp.2007.04.063
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 1008-1017
    • Machtay, M.1    Pajak, T.F.2    Suntharalingam, M.3    Shenouda, G.4    Hershock, D.5    Stripp, D.C.6
  • 105
    • 26944497269 scopus 로고    scopus 로고
    • Anemia, tumor hypoxemia, and the cancer patient
    • Varlotto J, Stevenson MA. Anemia, tumor hypoxemia, and the cancer patient. Int J Radiat Oncol Biol Phys 2005; 63: 25-36. doi: 10.1016/j.ijrobp.2005.04.049
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , pp. 25-36
    • Varlotto, J.1    Stevenson, M.A.2
  • 106
    • 33845739772 scopus 로고    scopus 로고
    • Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis
    • doi:10.1158/1078-0432.CCR-06-1285
    • Leo C, Horn LC, Rauscher C, Hentschel B, Liebmann A, Hildebrandt G, et al. Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis. Clin Cancer Res 2006; 12: 6894-900. doi:10.1158/1078-0432.CCR-06-1285
    • (2006) Clin Cancer Res , vol.12 , pp. 6894-6900
    • Leo, C.1    Horn, L.C.2    Rauscher, C.3    Hentschel, B.4    Liebmann, A.5    Hildebrandt, G.6
  • 107
    • 0027520210 scopus 로고
    • The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse
    • Joiner B, Hirst VK, McKeown SR, McAleer JJ, Hirst DG. The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse. Br J Cancer 1993; 68: 720-6.
    • (1993) Br J Cancer , vol.68 , pp. 720-726
    • Joiner, B.1    Hirst, V.K.2    McKeown, S.R.3    McAleer, J.J.4    Hirst, D.G.5
  • 108
    • 0035017208 scopus 로고    scopus 로고
    • Recombinant human erythropoietin increases the radiosensitivity of xenografted human tumours in anaemic nude mice
    • Stüben G, Thews O, Pöttgen C, Knühmann K, Vaupel P, Stuschke M. Recombinant human erythropoietin increases the radiosensitivity of xenografted human tumours in anaemic nude mice. J Cancer Res Clin Oncol 2001; 127: 346-50.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 346-350
    • Stüben, G.1    Thews, O.2    Pöttgen, C.3    Knühmann, K.4    Vaupel, P.5    Stuschke, M.6
  • 109
  • 110
    • 84864003904 scopus 로고    scopus 로고
    • Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer:results of a phase III randomized trial
    • Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, et al. Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer:results of a phase III randomized trial. J Clin Oncol 2012; 30: 1777-83. doi: 10.1200/JCO.2011.35.9315
    • (2012) J Clin Oncol , vol.30 , pp. 1777-1783
    • Janssens, G.O.1    Rademakers, S.E.2    Terhaard, C.H.3    Doornaert, P.A.4    Bijl, H.P.5    Van Den Ende, P.6
  • 111
    • 62649092475 scopus 로고    scopus 로고
    • Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: Mature results of a phase II nonrandomized study
    • Hoskin P, Rojas A, Saunders M. Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a phase II nonrandomized study. Int J Radiat Oncol Biol Phys 2009; 73: 1425-31.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 1425-1431
    • Hoskin, P.1    Rojas, A.2    Saunders, M.3
  • 112
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • doi:10.1038/nature10144
    • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011; 473: 298-307. doi:10.1038/nature10144
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 113
    • 70350244837 scopus 로고    scopus 로고
    • Hypoxia, angiogenesis and cancer therapy. to breathe or not to breathe?
    • Michieli P. Hypoxia, angiogenesis and cancer therapy. To breathe or not to breathe? Cell Cycle 2009; 8: 3291-6.
    • (2009) Cell Cycle , vol.8 , pp. 3291-3296
    • Michieli, P.1
  • 114
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8: 592-603. doi: 10.1038/nrc2442
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 115
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004; 4: 437-47. doi: 10.1038/nrc1367
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 117
    • 82255167669 scopus 로고    scopus 로고
    • Targeting hypoxic tumour cells to overcome metastasis
    • Bennewith KL, Dedhar S. Targeting hypoxic tumour cells to overcome metastasis. BMC Cancer 2011; 11: 504. doi: 10.1186/1471-2407-11-504
    • (2011) BMC Cancer , vol.11 , pp. 504
    • Bennewith, K.L.1    Dedhar, S.2
  • 118
    • 84893499123 scopus 로고    scopus 로고
    • Bioreductive prodrugs as cancer therapeutics: Targeting tumor hypoxia
    • Jul, Epub ahead of print
    • Guise CP, Mowday AM, Ashoorzadeh A, Yuan R, Lin WH, Wu DH, et al. Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia. Chin J Cancer Jul 2013. Epub ahead of print. doi: 10.5732/cjc.012.10285.
    • (2013) Chin J Cancer
    • Guise, C.P.1    Mowday, A.M.2    Ashoorzadeh, A.3    Yuan, R.4    Lin, W.H.5    Wu, D.H.6
  • 119
    • 33644817804 scopus 로고    scopus 로고
    • Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced nonsmall-cell lung cancer: Southwest Oncology Group Trial S0003
    • Williamson SK, Crowley JJ, Lara PN Jr, McCoy J, Lau DH, Tucker RW, et al. Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced nonsmall-cell lung cancer: Southwest Oncology Group Trial S0003. J Clin Oncol 2005; 23: 9097-104. doi: 10.1200/JCO.2005.01.3771
    • (2005) J Clin Oncol , vol.23 , pp. 9097-9104
    • Williamson, S.K.1    Crowley, J.J.2    Lara, P.N.3    McCoy, J.4    Lau, D.H.5    Tucker, R.W.6
  • 120
    • 77954600498 scopus 로고    scopus 로고
    • Tirapazamine, cisplatin and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group
    • Rischin D, Peters LJ, O'Sullivan B, Giralt J, Fisher R, Yuen K, et al. Tirapazamine, cisplatin and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group. J Clin Oncol 2010; 28: 2989-95. doi: 10.1200/JCO.2009.27.4449
    • (2010) J Clin Oncol , vol.28 , pp. 2989-2995
    • Rischin, D.1    Peters, L.J.2    O'sullivan, B.3    Giralt, J.4    Fisher, R.5    Yuen, K.6
  • 121
    • 84858204790 scopus 로고    scopus 로고
    • Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer
    • Le QT, Fisher R, Oliner KS, Young RJ, Cao H, Kong C, et al. Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer. Clin Cancer Res 2012; 18: 1798-807. doi: 10.1158/1078-0432.CCR-11-2094
    • (2012) Clin Cancer Res , vol.18 , pp. 1798-1807
    • Le Fisher, Q.T.R.1    Oliner, K.S.2    Young, R.J.3    Cao, H.4    Kong, C.5
  • 123
    • 77958060317 scopus 로고    scopus 로고
    • Pharmacokinetic/ pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
    • Hicks KO, Siim BG, Jaiswal JK, Pruijn FB, Fraser AM, Patel R, et al. Pharmacokinetic/ pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clin Cancer Res 2010; 16: 4946-57.
    • (2010) Clin Cancer Res , vol.16 , pp. 4946-4957
    • Hicks, K.O.1    Siim, B.G.2    Jaiswal, J.K.3    Pruijn, F.B.4    Fraser, A.M.5    Patel, R.6
  • 124
    • 79955490434 scopus 로고    scopus 로고
    • Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies
    • doi:10.1158/1078-0432.CCR-10-3425
    • Weiss GJ, Infante JR, Chiorean EG, Borad MJ, Bendell JC, Molina JR, et al. Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies. Clin Cancer Res 2011; 17: 2997-3004. doi:10.1158/1078-0432.CCR-10-3425
    • (2011) Clin Cancer Res , vol.17 , pp. 2997-3004
    • Weiss, G.J.1    Infante, J.R.2    Chiorean, E.G.3    Borad, M.J.4    Bendell, J.C.5    Molina, J.R.6
  • 125
    • 80053598625 scopus 로고    scopus 로고
    • A phase i trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients
    • McKeage MJ, Gu Y, Wilson WR, Hill A, Amies K, Melink TJ, et al. A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients. BMC Cancer 2011; 11: 432. doi: 10.1186/1471-2407-11-432
    • (2011) BMC Cancer , vol.11 , pp. 432
    • McKeage, M.J.1    Gu, Y.2    Wilson, W.R.3    Hill, A.4    Amies, K.5    Melink, T.J.6
  • 126
    • 84867748471 scopus 로고    scopus 로고
    • PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours
    • McKeage MJ, Jameson MB, Ramanathan RK, Rajendran J, Gu Y, Wilson WR, et al. PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours. BMC Cancer 2012; 12: 496. doi: 10.1186/1471-2407-12-496
    • (2012) BMC Cancer , vol.12 , pp. 496
    • McKeage, M.J.1    Jameson, M.B.2    Ramanathan, R.K.3    Rajendran, J.4    Gu, Y.5    Wilson, W.R.6


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