메뉴 건너뛰기




Volumn 112, Issue 3, 2011, Pages 735-744

Hypoxia-mediated biological control

Author keywords

Angiogenesis; Cardiovascular preconditioning; HIF; Hypoxia

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; VASCULOTROPIN;

EID: 79951807773     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22956     Document Type: Review
Times cited : (132)

References (110)
  • 7
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. 2000. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60:4693-4696.
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitenecker, G.5    Oberhuber, G.6
  • 8
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG, Hill RP. 2008. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8:180-192.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 9
    • 73249130655 scopus 로고    scopus 로고
    • Expression of HIF-1alpha and VEGF in colorectal cancer: Association with clinical outcomes and prognostic implications
    • Cao D, Hou M, Guan YS, Jiang M, Yang Y, Gou HF. 2009. Expression of HIF-1alpha and VEGF in colorectal cancer: Association with clinical outcomes and prognostic implications. BMC Cancer 9:432.
    • (2009) BMC Cancer , vol.9 , pp. 432
    • Cao, D.1    Hou, M.2    Guan, Y.S.3    Jiang, M.4    Yang, Y.5    Gou, H.F.6
  • 11
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A. 2001. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 276:9519-9525.
    • (2001) J Biol Chem , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 12
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • Chiche J, Brahimi-Horn MC, Pouysségur J. 2010. Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer. J Cell Mol Med 14:771-794.
    • (2010) J Cell Mol Med , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouysségur, J.3
  • 13
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: Insights from physiological angiogenesis
    • Chung AS, Lee J, Ferrara N. 2010. Targeting the tumour vasculature: Insights from physiological angiogenesis. Nat Rev Cancer 10:505-514.
    • (2010) Nat Rev Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 15
    • 77950690217 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer
    • Delli Carpini J, Karam AK, Montgomery L. 2010. Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer. Angiogenesis 13:43-58.
    • (2010) Angiogenesis , vol.13 , pp. 43-58
    • Delli Carpini, J.1    Karam, A.K.2    Montgomery, L.3
  • 16
    • 27144528715 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
    • DOI 10.1182/blood-2005-03-1138
    • Doege K, Heine S, Jensen I, Jelkmann W, Metzen E. 2005. Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact. Blood 106:2311-2317. (Pubitemid 41510801)
    • (2005) Blood , vol.106 , Issue.7 , pp. 2311-2317
    • Doege, K.1    Heine, S.2    Jensen, I.3    Jelkmann, W.4    Metzen, E.5
  • 17
    • 63849150122 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma
    • Dorevic G, Matusan-Ilijas K, Babarovic E, Hadzisejdic I, Grahovac M, Grahovac B, Jonjic N. 2009. Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma. J Exp Clin Cancer Res 28:40.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 40
    • Dorevic, G.1    Matusan-Ilijas, K.2    Babarovic, E.3    Hadzisejdic, I.4    Grahovac, M.5    Grahovac, B.6    Jonjic, N.7
  • 18
    • 18244372452 scopus 로고    scopus 로고
    • Endothelium-intrinsic requirement for Hif-2α during vascular development
    • DOI 10.1161/01.CIR.0000163580.98098.A3
    • Duan LJ, Zhang-Benoit Y, Fong GH. 2005. Endothelium-intrinsic requirement for Hif-2alpha during vascular development. Circulation 111:2227-2232. (Pubitemid 40632439)
    • (2005) Circulation , vol.111 , Issue.17 , pp. 2227-2232
    • Duan, L.-J.1    Zhang-Benoit, Y.2    Fong, G.-H.3
  • 19
    • 47649128513 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning
    • Eckle T, Kohler D, Lehmann R, El Kasmi KC, Eltzschig HK. 2008. Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning. Circulation 118:166-175.
    • (2008) Circulation , vol.118 , pp. 166-175
    • Eckle, T.1    Kohler, D.2    Lehmann, R.3    El Kasmi, K.C.4    Eltzschig, H.K.5
  • 22
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. 2003. The biology of VEGF and its receptors. Nat Med 9:669-676. (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 23
    • 77954563464 scopus 로고    scopus 로고
    • Hypoxia, inflammation, and the tumor microenvironment in metastatic disease
    • Finger E, Giaccia A. 2010. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev 29:285-293.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 285-293
    • Finger, E.1    Giaccia, A.2
  • 24
    • 49949152069 scopus 로고    scopus 로고
    • Mechanisms of adaptive angiogenesis to tissue hypoxia
    • Fong GH. 2008. Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis 11:121-140.
    • (2008) Angiogenesis , vol.11 , pp. 121-140
    • Fong, G.H.1
  • 27
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
    • DOI 10.1016/j.cell.2007.01.047, PII S0092867407003078
    • Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. 2007. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129:111-122. (Pubitemid 46507584)
    • (2007) Cell , vol.129 , Issue.1 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.-W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.6
  • 30
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes
    • Gerber H-P, Condorelli F, Park J, Ferrara N. 1997. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. J Biol Chem 272:23659-23667.
    • (1997) J Biol Chem , vol.272 , pp. 23659-23667
    • Gerber, H.-P.1    Condorelli, F.2    Park, J.3    Ferrara, N.4
  • 32
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third α- Class hypoxia inducible factor subunit, HIF3α
    • Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA. 1998. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 7:205-213. (Pubitemid 28527216)
    • (1998) Gene Expression , vol.7 , Issue.3 , pp. 205-213
    • Gu, Y.-Z.1    Moran, S.M.2    Hogenesch, J.B.3    Wartman, L.4    Bradfield, C.A.5
  • 33
    • 77953854244 scopus 로고    scopus 로고
    • Hypoxic regulation of erythropoiesis and iron metabolism
    • Haase VH. 2010. Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol 299:F1-F13.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Haase, V.H.1
  • 34
    • 0348134741 scopus 로고    scopus 로고
    • Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
    • DOI 10.1126/science.1088805
    • Hagen T, Taylor CT, Lam F, Moncada S. 2003. Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha. Science 302:1975-1978. (Pubitemid 37523507)
    • (2003) Science , vol.302 , Issue.5652 , pp. 1975-1978
    • Hagen, T.1    Taylor, C.T.2    Lam, F.3    Moncada, S.4
  • 35
    • 34249007471 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling
    • DOI 10.1160/TH06-12-0744
    • Hanze J, Weissmann N, Grimminger F, Seeger W, Rose F. 2007. Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling. Thromb Haemost 97:774-787. (Pubitemid 46779962)
    • (2007) Thrombosis and Haemostasis , vol.97 , Issue.5 , pp. 774-787
    • Hanze, J.1    Weissmann, N.2    Grimminger, F.3    Seeger, W.4    Rose, F.5
  • 36
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL. 2002. Hypoxia - A key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47. (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 37
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • DOI 10.1074/jbc.M304982200
    • Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. 2003. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278:30772-30780. (Pubitemid 36994584)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 30772-30780
    • Hirsila, M.1    Koivunen, P.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 38
    • 0345491599 scopus 로고    scopus 로고
    • Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
    • DOI 10.1128/MCB.23.24.9361-9374.2003
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. 2003. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23:9361-9374. (Pubitemid 37499822)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.24 , pp. 9361-9374
    • Hu, C.-J.1    Wang, L.-Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 42
    • 77951552411 scopus 로고    scopus 로고
    • Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
    • Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J. 2010. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem 285:13646-13657.
    • (2010) J Biol Chem , vol.285 , pp. 13646-13657
    • Hyvarinen, J.1    Hassinen, I.E.2    Sormunen, R.3    Maki, J.M.4    Kivirikko, K.I.5    Koivunen, P.6    Myllyharju, J.7
  • 43
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • Imai T, Horiuchi A, Wang C, Oka K, Ohira S, Nikaido T, Konishi I. 2003. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 163:1437-1447. (Pubitemid 37175091)
    • (2003) American Journal of Pathology , vol.163 , Issue.4 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3    Oka, K.4    Ohira, S.5    Nikaido, T.6    Konishi, I.7
  • 44
    • 3142672781 scopus 로고    scopus 로고
    • Protocol of radiotherapy for glioblastoma according to the expression of HIF-1
    • DOI 10.1007/BF02482169
    • Irie N, Matsuo T, Nagata I. 2004. Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathol 21:1-6. (Pubitemid 38915175)
    • (2004) Brain Tumor Pathology , vol.21 , Issue.1 , pp. 1-6
    • Irie, N.1    Matsuo, T.2    Nagata, I.3
  • 46
    • 0344874751 scopus 로고    scopus 로고
    • Cell Type-Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1
    • DOI 10.1161/01.RES.0000102937.50486.1B
    • Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. 2003. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93:1074-1081. (Pubitemid 37485038)
    • (2003) Circulation Research , vol.93 , Issue.11 , pp. 1074-1081
    • Kelly, B.D.1    Hackett, S.F.2    Hirota, K.3    Oshima, Y.4    Cai, Z.5    Berg-Dixon, S.6    Rowan, A.7    Yan, Z.8    Campochiaro, P.A.9    Semenza, G.L.10
  • 47
    • 28244446238 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
    • DOI 10.1016/j.jacc.2005.08.045, PII S0735109705022047
    • Kido M, Du L, Sullivan C, Li X, Deutsch R, Jamieson SW, Thistlethwaite PA. 2005. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 46:2116-2124. (Pubitemid 41713601)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.11 , pp. 2116-2124
    • Kido, M.1    Du, L.2    Sullivan, C.C.3    Li, X.4    Deutsch, R.5    Jamieson, S.W.6    Thistlethwaite, P.A.7
  • 48
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. 2006. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3:177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 49
    • 33645090169 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
    • Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. 2006. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 66: 2725-2731.
    • (2006) Cancer Res , vol.66 , pp. 2725-2731
    • Krishnamachary, B.1    Zagzag, D.2    Nagasawa, H.3    Rainey, K.4    Okuyama, H.5    Baek, J.H.6    Semenza, G.L.7
  • 51
    • 77951123815 scopus 로고    scopus 로고
    • Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and 124I-cG250 PET/CT
    • Epub ahead of print
    • Lawrentschuk N, Lee F, Jones G, Rigopoulos A, Mountain A, O'Keefe G, Papenfuss A, Bolton D, Davis I, Scott A. 2009. Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and 124I-cG250 PET/CT. Urol Oncol [Epub ahead of print].
    • (2009) Urol Oncol
    • Lawrentschuk, N.1    Lee, F.2    Jones, G.3    Rigopoulos, A.4    Mountain, A.5    O'Keefe, G.6    Papenfuss, A.7    Bolton, D.8    Davis, I.9    Scott, A.10
  • 53
    • 0032513043 scopus 로고    scopus 로고
    • Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
    • DOI 10.1074/jbc.273.11.6417
    • Levy NS, Chung S, Furneaux H, Levy AP. 1998. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 273:6417-6423. (Pubitemid 28144735)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.11 , pp. 6417-6423
    • Levy, N.S.1    Chung, S.2    Furneaux, H.3    Levy, A.P.4
  • 55
    • 33846652552 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression
    • DOI 10.1158/0008-5472.CAN-06-2701
    • Liao D, Corle C, Seagroves TN, Johnson RS. 2007. Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67:563-572. (Pubitemid 46192193)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 563-572
    • Liao, D.1    Corle, C.2    Seagroves, T.N.3    Johnson, R.S.4
  • 56
    • 40949132841 scopus 로고    scopus 로고
    • Turn me on: Regulating HIF transcriptional activity
    • DOI 10.1038/sj.cdd.4402315, PII 4402315, The biology of Hypoxia-inducible factors
    • Lisy K, Peet DJ. 2008. Turn me on: Regulating HIF transcriptional activity. Cell Death Differ 15:642-649. (Pubitemid 351405067)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.4 , pp. 642-649
    • Lisy, K.1    Peet, D.J.2
  • 57
    • 0034190304 scopus 로고    scopus 로고
    • Calcium signaling and oxidant stress in the vasculature
    • DOI 10.1016/S0891-5849(00)00222-7, PII S0891584900002227
    • Lounsbury KM, Hu Q, Ziegelstein RC. 2000. Calcium signaling and oxidant stress in the vasculature. Free Radic Biol Med 28:1362-1369. (Pubitemid 30621480)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.9 , pp. 1362-1369
    • Lounsbury, K.M.1    Hu, Q.2    Ziegelstein, R.C.3
  • 58
    • 0034016439 scopus 로고    scopus 로고
    • Disease control of uterine cervical cancer: Relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy
    • Lyng H, Sundfor K, Trope C, Rofstad EK. 2000. Disease control of uterine cervical cancer: Relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy. Clin Cancer Res 6:1104-1112. (Pubitemid 30159373)
    • (2000) Clinical Cancer Research , vol.6 , Issue.3 , pp. 1104-1112
    • Lyng, H.1    Sundfor, K.2    Trope, C.3    Rofstad, E.K.4
  • 59
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
    • DOI 10.1101/gad.924501
    • Mahon PC, Hirota K, Semenza GL. 2001. FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686. (Pubitemid 32988878)
    • (2001) Genes and Development , vol.15 , Issue.20 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 60
    • 0035969508 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
    • DOI 10.1038/35107085
    • Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L. 2001. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414: 550-554. (Pubitemid 33131538)
    • (2001) Nature , vol.414 , Issue.6863 , pp. 550-554
    • Makino, Y.1    Cao, R.2    Svensson, K.3    Bertilsson, G.4    Asman, M.5    Tanaka, H.6    Cao, Y.7    Berkenstam, A.8    Poellinger, L.9
  • 63
    • 24644484730 scopus 로고    scopus 로고
    • Human HIF-3α4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma
    • DOI 10.1096/fj.05-3788com
    • Maynard MA, Evans AJ, Hosomi T, Hara S, Jewett MA, Ohh M. 2005. Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. FASEB J 19:1396-1406. (Pubitemid 41278998)
    • (2005) FASEB Journal , vol.19 , Issue.11 , pp. 1396-1406
    • Maynard, M.A.1    Evans, A.J.2    Hosomi, T.3    Hara, S.4    Jewett, M.A.S.5    Ohh, M.6
  • 64
    • 41749099273 scopus 로고    scopus 로고
    • Cellular oxygen sensing in health and disease
    • DOI 10.1007/s00467-007-0632-x
    • Mole DR, Ratcliffe PJ. 2008. Cellular oxygen sensing in health and disease. Pediatr Nephrol 23:681-694. (Pubitemid 351486180)
    • (2008) Pediatric Nephrology , vol.23 , Issue.5 , pp. 681-694
    • Mole, D.R.1    Ratcliffe, P.J.2
  • 66
    • 0034647742 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
    • DOI 10.1074/jbc.M000636200
    • Mukhopadhyay CK, Mazumder B, Fox PL. 2000. Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem 275:21048-21054. (Pubitemid 30481794)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.28 , pp. 21048-21054
    • Mukhopadhyay, C.K.1    Mazumder, B.2    Fox, P.L.3
  • 68
    • 16544375464 scopus 로고    scopus 로고
    • Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: Prognostic significance
    • Nam DH, Park K, Suh YL, Kim JH. 2004. Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: Prognostic significance. Oncol Rep 11:863-869.
    • (2004) Oncol Rep , vol.11 , pp. 863-869
    • Nam, D.H.1    Park, K.2    Suh, Y.L.3    Kim, J.H.4
  • 69
    • 34547838192 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1α, hypoxia-inducible factor 2α, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1α is an independent prognostic factor in ovarian carcinoma
    • DOI 10.1016/j.humpath.2007.02.010, PII S0046817707000998
    • Osada R, Horiuchi A, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama Y, Melillo G, Konishi I. 2007. Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. Hum Pathol 38:1310-1320. (Pubitemid 47247486)
    • (2007) Human Pathology , vol.38 , Issue.9 , pp. 1310-1320
    • Osada, R.1    Horiuchi, A.2    Kikuchi, N.3    Yoshida, J.4    Hayashi, A.5    Ota, M.6    Katsuyama, Y.7    Mellilo, G.8    Konishi, I.9
  • 70
    • 33846630894 scopus 로고    scopus 로고
    • Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro
    • DOI 10.1128/MCB.01223-06
    • Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC. 2007. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol 27:912-925. (Pubitemid 46174556)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.3 , pp. 912-925
    • Pan, Y.1    Mansfield, K.D.2    Bertozzi, C.C.3    Rudenko, V.4    Chan, D.A.5    Giaccia, A.J.6    Simon, M.C.7
  • 71
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper MS, Ferrara N, Orci L, Montesano R. 1991. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181:902-906.
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 72
    • 38349111676 scopus 로고    scopus 로고
    • Role of the hypoxia inducible factors HIF in iron metabolism
    • Peyssonnaux C, Nizet V, Johnson RS. 2008. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 7:28-32.
    • (2008) Cell Cycle , vol.7 , pp. 28-32
    • Peyssonnaux, C.1    Nizet, V.2    Johnson, R.S.3
  • 73
    • 78751584845 scopus 로고    scopus 로고
    • Expressions of hypoxia-inducible factor-1alpha and hexokinase-II in gastric adenocarcinoma: The impact on prognosis and correlation to clinicopathologic features
    • Qiu MZ, Han B, Luo HY, Zhou ZW, Wang ZQ, Wang FH, Li YH, Xu RH. 2010. Expressions of hypoxia-inducible factor-1alpha and hexokinase-II in gastric adenocarcinoma: The impact on prognosis and correlation to clinicopathologic features. Tumour Biol 32(1):159-166.
    • (2010) Tumour Biol , vol.32 , Issue.1 , pp. 159-166
    • Qiu, M.Z.1    Han, B.2    Luo, H.Y.3    Zhou, Z.W.4    Wang, Z.Q.5    Wang, F.H.6    Li, Y.H.7    Xu, R.H.8
  • 74
    • 65249185780 scopus 로고    scopus 로고
    • Downregulation of MiR-199a derepresses hypoxia-inducible factor-1{alpha} and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    • Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. 2009. Downregulation of MiR-199a derepresses hypoxia-inducible factor-1{alpha} and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 104:879-886.
    • (2009) Circ Res , vol.104 , pp. 879-886
    • Rane, S.1    He, M.2    Sayed, D.3    Vashistha, H.4    Malhotra, A.5    Sadoshima, J.6    Vatner, D.E.7    Vatner, S.F.8    Abdellatif, M.9
  • 75
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • DOI 10.1038/cdd.2008.21, PII CDD200821, The biology of Hypoxia-inducible factors
    • Rankin EB, Giaccia AJ. 2008. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 15:678-685. (Pubitemid 351405072)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.4 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 76
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • Rolfe DF, Brown GC. 1997. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 77:731-758. (Pubitemid 27328739)
    • (1997) Physiological Reviews , vol.77 , Issue.3 , pp. 731-758
    • Rolfe, D.F.S.1    Brown, G.C.2
  • 77
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1α is required for solid tumor formation and embryonic vascularization
    • DOI 10.1093/emboj/17.11.3005
    • Ryan HE, Lo J, Johnson RS. 1998. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17:3005-3015. (Pubitemid 28254373)
    • (1998) EMBO Journal , vol.17 , Issue.11 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 78
    • 65549105393 scopus 로고    scopus 로고
    • Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: Systematic review and meta-analysis
    • Schoenleber SJ, Kurtz DM, Talwalkar JA, Roberts LR, Gores GJ. 2009. Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: Systematic review and meta-analysis. Br J Cancer 100:1385-1392.
    • (2009) Br J Cancer , vol.100 , pp. 1385-1392
    • Schoenleber, S.J.1    Kurtz, D.M.2    Talwalkar, J.A.3    Roberts, L.R.4    Gores, G.J.5
  • 81
    • 0035313697 scopus 로고    scopus 로고
    • HIF-1 and mechanisms of hypoxia sensing
    • DOI 10.1016/S0955-0674(00)00194-0
    • Semenza GL. 2001. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13:167-171. (Pubitemid 32209217)
    • (2001) Current Opinion in Cell Biology , vol.13 , Issue.2 , pp. 167-171
    • Semenza, G.L.1
  • 82
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. 2003. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732. (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 83
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. 2010. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-634.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 85
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. 1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447-5454.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 86
    • 0032491429 scopus 로고    scopus 로고
    • Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro
    • DOI 10.1074/jbc.273.45.29979
    • Shen B-Q, Lee DY, Gerber H-P, Keyt BA, Ferrara N, Zioncheck TF. 1998. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro. J Biol Chem 273:29979-29985. (Pubitemid 28510016)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.45 , pp. 29979-29985
    • Shen, B.-Q.1    Lee, D.Y.2    Gerber, H.-P.3    Keyt, B.A.4    Ferrara, N.5    Zioncheck, T.F.6
  • 87
    • 33751117499 scopus 로고    scopus 로고
    • HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
    • Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. 2006. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 291:L941-L949.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Shimoda, L.A.1    Fallon, M.2    Pisarcik, S.3    Wang, J.4    Semenza, G.L.5
  • 88
    • 41149115123 scopus 로고    scopus 로고
    • The role of oxygen availability in embryonic development and stem cell function
    • Simon MC, Keith B. 2008. The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 9:285-296.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 285-296
    • Simon, M.C.1    Keith, B.2
  • 89
    • 16344389190 scopus 로고    scopus 로고
    • Angiogenesis: Where do we stand now?
    • Simons M. 2005. Angiogenesis: Where do we stand now? Circulation 111:1556-1566.
    • (2005) Circulation , vol.111 , pp. 1556-1566
    • Simons, M.1
  • 90
    • 0036721256 scopus 로고    scopus 로고
    • Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    • Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. 2002. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 95:1055-1063.
    • (2002) Cancer , vol.95 , pp. 1055-1063
    • Sivridis, E.1    Giatromanolaki, A.2    Gatter, K.C.3    Harris, A.L.4    Koukourakis, M.I.5
  • 91
    • 77955291967 scopus 로고    scopus 로고
    • The altered metabolism of tumors: HIF-1 and its role in the Warburg effect
    • Stubbs M, Griffiths JR. 2010. The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. Adv Enzyme Regul 50:44-55.
    • (2010) Adv Enzyme Regul , vol.50 , pp. 44-55
    • Stubbs, M.1    Griffiths, J.R.2
  • 92
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. 2000. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411-421.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 93
    • 38149059911 scopus 로고    scopus 로고
    • Mitochondria and cellular oxygen sensing in the HIF pathway
    • Taylor CT. 2008. Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem J 409:19-26.
    • (2008) Biochem J , vol.409 , pp. 19-26
    • Taylor, C.T.1
  • 94
    • 78549270044 scopus 로고    scopus 로고
    • Antiangiogenic agents and targets: A perspective
    • Teicher BA. 2010. Antiangiogenic agents and targets: A perspective. Biochem Pharmacol 81(1):6-12.
    • (2010) Biochem Pharmacol , vol.81 , Issue.1 , pp. 6-12
    • Teicher, B.A.1
  • 96
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. 1997. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 97
    • 50949121232 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for critical limb ischemia: Microvascular therapies coming of age
    • Tongers J, Roncalli JG, Losordo DW. 2008. Therapeutic angiogenesis for critical limb ischemia: Microvascular therapies coming of age. Circulation 118:9-16.
    • (2008) Circulation , vol.118 , pp. 9-16
    • Tongers, J.1    Roncalli, J.G.2    Losordo, D.W.3
  • 98
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha dependent mechanism
    • Ullah MS, Davies AJ, Halestrap AP. 2006. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha dependent mechanism. J Biol Chem 281:9030-9037.
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 99
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 100
    • 0036021479 scopus 로고    scopus 로고
    • Hypoxia in breast cancer: Pathogenesis, characterization and biological/therapeutic implications
    • Vaupel P, Briest S, Hockel M. 2002. Hypoxia in breast cancer: Pathogenesis, characterization and biological/therapeutic implications. Wien Med Wochenschr 152:334-342.
    • (2002) Wien Med Wochenschr , vol.152 , pp. 334-342
    • Vaupel, P.1    Briest, S.2    Hockel, M.3
  • 102
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
    • Wang V, Davis DA, Haque M, Huang LE, Yarchoan R. 2005. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res 65:3299-3306.
    • (2005) Cancer Res , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 103
    • 1442339194 scopus 로고    scopus 로고
    • Nitric oxide and reactive oxygen species exert opposing effects on the stability of hypoxia-inducible factor-1alpha (HIF-1alpha) in explants of human pial arteries
    • Wellman TL, Jenkins J, Penar PL, Tranmer B, Zahr R, Lounsbury KM. 2004. Nitric oxide and reactive oxygen species exert opposing effects on the stability of hypoxia-inducible factor-1alpha (HIF-1alpha) in explants of human pial arteries. FASEB J 18:379-381.
    • (2004) FASEB J , vol.18 , pp. 379-381
    • Wellman, T.L.1    Jenkins, J.2    Penar, P.L.3    Tranmer, B.4    Zahr, R.5    Lounsbury, K.M.6
  • 105
    • 1642341137 scopus 로고    scopus 로고
    • VEGF and HIF-1alpha expression are increased in advanced stages of epithelial ovarian cancer
    • Wong C, Wellman TL, Lounsbury KM. 2003. VEGF and HIF-1alpha expression are increased in advanced stages of epithelial ovarian cancer. Gynecol Oncol 91:513-517.
    • (2003) Gynecol Oncol , vol.91 , pp. 513-517
    • Wong, C.1    Wellman, T.L.2    Lounsbury, K.M.3
  • 107
    • 77954608736 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of HIF-1alpha prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice
    • Xue W, Cai L, Tan Y, Thistlethwaite P, Kang YJ, Li X, Feng W. 2010. Cardiac-specific overexpression of HIF-1alpha prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice. Am J Pathol 177:97-105.
    • (2010) Am J Pathol , vol.177 , pp. 97-105
    • Xue, W.1    Cai, L.2    Tan, Y.3    Thistlethwaite, P.4    Kang, Y.J.5    Li, X.6    Feng, W.7
  • 109
    • 34447635558 scopus 로고    scopus 로고
    • Over-expression of hypoxia-inducible factor-1alpha in human osteosarcoma: Correlation with clinicopathological parameters and survival outcome
    • Yang QC, Zeng BF, Dong Y, Shi ZM, Jiang ZM, Huang J. 2007. Over-expression of hypoxia-inducible factor-1alpha in human osteosarcoma: Correlation with clinicopathological parameters and survival outcome. Jpn J Clin Oncol 37:127-134.
    • (2007) Jpn J Clin Oncol , vol.37 , pp. 127-134
    • Yang, Q.C.1    Zeng, B.F.2    Dong, Y.3    Shi, Z.M.4    Jiang, Z.M.5    Huang, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.