DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative twinkle helicase

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 29975-29993

  Bharti, Sanjay Kumar ^a   Sommers, Joshua A ^a   Zhou, Jun ^b,c   Kaplan, Daniel L ^d   Spelbrink, Johannes N ^e,f   Mergny, Jean Louis ^b,c   Brosh, Robert M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c INSTITUT EUROPÉEN DE CHIMIE ET BIOLOGIE   (France)

^d FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; DICHROISM; DISEASES; DNA; FACSIMILE; GENES; MACHINERY; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS; SUBSTRATES;

BIOCHEMICAL ANALYSIS; COMPUTATIONAL ANALYSIS; HUMAN GENETIC DISORDERS; MITOCHONDRIAL GENOMES; MOLECULAR DETERMINANTS; RENAL CELL CARCINOMA; REPLICATION MACHINERY; SOURCE OF INSTABILITY;

DNA SEQUENCES;

GUANINE QUADRUPLEX; HELICASE; MITOCHONDRIAL DNA; TWINKLE HELICASE; UNCLASSIFIED DRUG; C10ORF2 PROTEIN, HUMAN; DNA HELICASE; MITOCHONDRIAL PROTEIN; RECOMBINANT PROTEIN;

AGING; ARTICLE; CIRCULAR DICHROISM; COLON ADENOCARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; DNA STRUCTURE; GENE PRODUCT; GENETIC DISORDER; GENOMIC INSTABILITY; IN VITRO STUDY; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LIVER TUMOR; LUNG CANCER; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL DNA DEPLETION SYNDROME; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL GENOME; NUCLEOTIDE SEQUENCE; PROTEIN DNA INTERACTION; PROTEIN SECONDARY STRUCTURE; THYROID TUMOR; ULTRAVIOLET SPECTROSCOPY; ANIMAL; BIOLOGY; DISEASES; DNA DAMAGE; DNA DENATURATION; DNA REPLICATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENE DELETION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MITOCHONDRION; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE MOTIF; TELOMERE; ULTRAVIOLET RADIATION;

AGING; ANIMALS; BASE SEQUENCE; CIRCULAR DICHROISM; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DISEASE; DNA DAMAGE; DNA HELICASES; DNA REPLICATION; DNA, MITOCHONDRIAL; EVOLUTION, MOLECULAR; G-QUADRUPLEXES; GENOME, MITOCHONDRIAL; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASMS; NUCLEIC ACID DENATURATION; NUCLEOTIDE MOTIFS; RECOMBINANT PROTEINS; SEQUENCE DELETION; SUBSTRATE SPECIFICITY; TELOMERE; ULTRAVIOLET RAYS;

EID: 84908178815     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.567073     Document Type: Article

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