메뉴 건너뛰기




Volumn 126, Issue 2, 2006, Pages 336-344

Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MITOCHONDRIAL DNA;

EID: 33644647886     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700088     Document Type: Article
Times cited : (86)

References (56)
  • 2
    • 0019423856 scopus 로고
    • Sequence and organization of the human mitochondrial genome
    • Anderson S, Bankier AT, Barrell BG et al. (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457-65
    • (1981) Nature , vol.290 , pp. 457-465
    • Anderson, S.1    Bankier, A.T.2    Barrell, B.G.3
  • 4
    • 0031196736 scopus 로고    scopus 로고
    • Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system
    • Berneburg M, Gattermann N, Stege H, Grewe M, Vogelsang K, Ruzicka T et al. (1997) Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem Photobiol 66:271-5
    • (1997) Photochem Photobiol , vol.66 , pp. 271-275
    • Berneburg, M.1    Gattermann, N.2    Stege, H.3    Grewe, M.4    Vogelsang, K.5    Ruzicka, T.6
  • 5
    • 24344463478 scopus 로고    scopus 로고
    • Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences
    • Berneburg M, Gremmel T, Kurten V et al. (2005) Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences. J Invest Dermatol 125:213-20
    • (2005) J Invest Dermatol , vol.125 , pp. 213-220
    • Berneburg, M.1    Gremmel, T.2    Kurten, V.3
  • 6
    • 0033016467 scopus 로고    scopus 로고
    • Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion
    • Berneburg M, Grether-Beck S, Kurten V, Ruzicka T, Briviba K, Sies H et al. (1999) Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem 274:15345-9
    • (1999) J Biol Chem , vol.274 , pp. 15345-15349
    • Berneburg, M.1    Grether-Beck, S.2    Kurten, V.3    Ruzicka, T.4    Briviba, K.5    Sies, H.6
  • 8
    • 0031906187 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions in human skin reflect photo- Rather than chronologic aging
    • Birch-Machin MA, Tindall M, Turner R, Haldane F, Rees JL (1998) Mitochondrial DNA deletions in human skin reflect photo- rather than chronologic aging. J Invest Dermatol 110:149-52
    • (1998) J Invest Dermatol , vol.110 , pp. 149-152
    • Birch-Machin, M.A.1    Tindall, M.2    Turner, R.3    Haldane, F.4    Rees, J.L.5
  • 9
    • 0031885843 scopus 로고    scopus 로고
    • Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
    • Brierley EJ, Johnson MA, Lightowlers RN, James OF, Turnbull DM (1998) Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann Neurol 43:217-23
    • (1998) Ann Neurol , vol.43 , pp. 217-223
    • Brierley, E.J.1    Johnson, M.A.2    Lightowlers, R.N.3    James, O.F.4    Turnbull, D.M.5
  • 10
    • 0000825475 scopus 로고
    • The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria
    • Clayton DA, Doda JN, Friedberg EC (1974) The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci USA 71:2777-81
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 2777-2781
    • Clayton, D.A.1    Doda, J.N.2    Friedberg, E.C.3
  • 11
    • 0034972303 scopus 로고    scopus 로고
    • High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection
    • Coller HA, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG (2001) High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet 28:147-50
    • (2001) Nat Genet , vol.28 , pp. 147-150
    • Coller, H.A.1    Khrapko, K.2    Bodyak, N.D.3    Nekhaeva, E.4    Herrero-Jimenez, P.5    Thilly, W.G.6
  • 13
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • Cortopassi CA, Arnheim N (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18:6927-33
    • (1990) Nucleic Acids Res , vol.18 , pp. 6927-6933
    • Cortopassi, C.A.1    Arnheim, N.2
  • 14
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Cortopassi GA, Shibata D, Soong NW, Arnheim N (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 89:7370-4
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1    Shibata, D.2    Soong, N.W.3    Arnheim, N.4
  • 15
    • 0032694302 scopus 로고    scopus 로고
    • The broad spectrum of responses to oxidants in proliferating cells: A new paradigm for oxidative stress
    • Davies KJ (1999) The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life 48:41-7
    • (1999) IUBMB Life , vol.48 , pp. 41-47
    • Davies, K.J.1
  • 17
    • 0037364314 scopus 로고    scopus 로고
    • A role for mitochondrial enzymes in inherited neoplasia and beyond
    • Eng C, Kiuru M, Fernandez MJ, Aaltonen LA (2003) A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat Rev Cancer 3:193-202
    • (2003) Nat Rev Cancer , vol.3 , pp. 193-202
    • Eng, C.1    Kiuru, M.2    Fernandez, M.J.3    Aaltonen, L.A.4
  • 18
    • 0039250954 scopus 로고    scopus 로고
    • Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
    • Fliss MS, Usadel H, Caballero OL et al. (2000) Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 287:2017-9
    • (2000) Science , vol.287 , pp. 2017-2019
    • Fliss, M.S.1    Usadel, H.2    Caballero, O.L.3
  • 19
    • 0017171254 scopus 로고
    • Mutator activity of petite strains of Saccharomyces cerevisiae
    • Flury F, von Borstel RC, Williamson DH (1976) Mutator activity of petite strains of Saccharomyces cerevisiae. Genetics 83:645-53
    • (1976) Genetics , vol.83 , pp. 645-653
    • Flury, F.1    Von Borstel, R.C.2    Williamson, D.H.3
  • 20
    • 0034989085 scopus 로고    scopus 로고
    • Local rates of recombination are positively correlated with GC content in the human genome
    • Fullerton SM, Bernardo Carvalho A, Clark AG (2001) Local rates of recombination are positively correlated with GC content in the human genome. Mol Biol Evol 18:1139-42
    • (2001) Mol Biol Evol , vol.18 , pp. 1139-1142
    • Fullerton, S.M.1    Bernardo Carvalho, A.2    Clark, A.G.3
  • 22
    • 2942623969 scopus 로고    scopus 로고
    • Implications of using the ND1 gene as a control region for real-time PCR analysis of mitochondrial DNA deletions in human skin
    • Harbottle A, Krishnan KJ, Birch-Machin MA (2004) Implications of using the ND1 gene as a control region for real-time PCR analysis of mitochondrial DNA deletions in human skin. J Invest Dermatol 122:1518-21
    • (2004) J Invest Dermatol , vol.122 , pp. 1518-1521
    • Harbottle, A.1    Krishnan, K.J.2    Birch-Machin, M.A.3
  • 23
    • 0029765459 scopus 로고    scopus 로고
    • The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA
    • Hou JH, Wei YH (1996) The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA. Biochem J 318(Part 3):1065-70
    • (1996) Biochem J , vol.318 , Issue.3 PART , pp. 1065-1070
    • Hou, J.H.1    Wei, Y.H.2
  • 24
    • 0025113789 scopus 로고
    • Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence
    • Ikebe S, Tanaka M, Ohno K et al. (1990) Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem Biophys Res Commun 170:1044-8
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 1044-1048
    • Ikebe, S.1    Tanaka, M.2    Ohno, K.3
  • 25
    • 0033772263 scopus 로고    scopus 로고
    • Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes
    • Inoue K, Nakada K, Ogura A, Isobe K, Goto Y, Nonaka I et al. (2000) Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes. Nat Genet 26:176-81
    • (2000) Nat Genet , vol.26 , pp. 176-181
    • Inoue, K.1    Nakada, K.2    Ogura, A.3    Isobe, K.4    Goto, Y.5    Nonaka, I.6
  • 27
    • 0034783384 scopus 로고    scopus 로고
    • In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet a irradiation
    • Koch H, Wittern KP, Bergemann J (2001) In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation. J Invest Dermatol 117:892-7
    • (2001) J Invest Dermatol , vol.117 , pp. 892-897
    • Koch, H.1    Wittern, K.P.2    Bergemann, J.3
  • 29
    • 9744276756 scopus 로고    scopus 로고
    • The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin
    • Krishnan KJ, Harbottle A, Birch-Machin MA (2004) The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin. J Invest Dermatol 123:1020-4
    • (2004) J Invest Dermatol , vol.123 , pp. 1020-1024
    • Krishnan, K.J.1    Harbottle, A.2    Birch-Machin, M.A.3
  • 30
    • 0002026429 scopus 로고    scopus 로고
    • Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin
    • Lu CY, Lee HC, Fahn HJ, Wei YH (1999) Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res 423:11-21
    • (1999) Mutat Res , vol.423 , pp. 11-21
    • Lu, C.Y.1    Lee, H.C.2    Fahn, H.J.3    Wei, Y.H.4
  • 31
    • 0027166063 scopus 로고
    • In vivo and in vitro evidence for slipped mispairing in mammalian mitochondria
    • Madsen CS, Ghivizzani SC, Hauswirth WW (1993) In vivo and in vitro evidence for slipped mispairing in mammalian mitochondria. Proc Natl Acad Sci USA 90:7671-5
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7671-7675
    • Madsen, C.S.1    Ghivizzani, S.C.2    Hauswirth, W.W.3
  • 32
    • 0025044656 scopus 로고
    • Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA
    • Mita S, Rizzuto R, Moraes CT et al. (1990) Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA. Nucleic Acids Res 18:561-7
    • (1990) Nucleic Acids Res , vol.18 , pp. 561-567
    • Mita, S.1    Rizzuto, R.2    Moraes, C.T.3
  • 33
    • 0032401024 scopus 로고    scopus 로고
    • Ageing and mammalian mitochondrial genetics
    • Nagley P, Wei YH (1998) Ageing and mammalian mitochondrial genetics. Trends Genet 14:513-7
    • (1998) Trends Genet , vol.14 , pp. 513-517
    • Nagley, P.1    Wei, Y.H.2
  • 34
    • 0027941299 scopus 로고
    • Human skin mitochondrial DNA deletions associated with light exposure
    • Pang CY, Lee HC, Yang JH, Wei YH (1994) Human skin mitochondrial DNA deletions associated with light exposure. Arch Biochem Biophys 312:534-8
    • (1994) Arch Biochem Biophys , vol.312 , pp. 534-538
    • Pang, C.Y.1    Lee, H.C.2    Yang, J.H.3    Wei, Y.H.4
  • 36
  • 37
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • Polyak K, Li Y, Zhu H et al. (1998) Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 20:291-3
    • (1998) Nat Genet , vol.20 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3
  • 38
    • 0033774235 scopus 로고    scopus 로고
    • The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin
    • Ray AJ, Turner R, Nikaido O, Rees JL, Birch-Machin MA (2000) The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin. J Invest Dermatol 115:674-9
    • (2000) J Invest Dermatol , vol.115 , pp. 674-679
    • Ray, A.J.1    Turner, R.2    Nikaido, O.3    Rees, J.L.4    Birch-Machin, M.A.5
  • 39
    • 0029116061 scopus 로고
    • Oxidative damage to mitochondrial DNA and its relationship to ageing
    • Richter C (1995) Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 27:647-53
    • (1995) Int J Biochem Cell Biol , vol.27 , pp. 647-653
    • Richter, C.1
  • 40
    • 4143081492 scopus 로고    scopus 로고
    • Two direct repeats cause most human mtDNA deletions
    • Samuels DC, Schon EA, Chinnery PF (2004) Two direct repeats cause most human mtDNA deletions. Trends Genet 20:393-8
    • (2004) Trends Genet , vol.20 , pp. 393-398
    • Samuels, D.C.1    Schon, E.A.2    Chinnery, P.F.3
  • 42
    • 0024596946 scopus 로고
    • A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA
    • Schon EA, Rizzuto R, Moraes CT, Nakase H, Zeviani M, DiMauro S (1989) A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA. Science 244:346-9
    • (1989) Science , vol.244 , pp. 346-349
    • Schon, E.A.1    Rizzuto, R.2    Moraes, C.T.3    Nakase, H.4    Zeviani, M.5    DiMauro, S.6
  • 43
    • 0028140454 scopus 로고
    • Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy
    • Sciacco M, Bonilla E, Schon EA, DiMauro S, Moraes CT (1994) Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy. Hum Mol Genet 3:13-9
    • (1994) Hum Mol Genet , vol.3 , pp. 13-19
    • Sciacco, M.1    Bonilla, E.2    Schon, E.A.3    DiMauro, S.4    Moraes, C.T.5
  • 45
    • 24344447309 scopus 로고    scopus 로고
    • H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo
    • Shin MH, Rhie GE, Kim YK et al. (2005) H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo. J Invest Dermatol 125:221-9
    • (2005) J Invest Dermatol , vol.125 , pp. 221-229
    • Shin, M.H.1    Rhie, G.E.2    Kim, Y.K.3
  • 46
    • 0024317560 scopus 로고
    • Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy
    • Shoffner JM, Lott MT, Voljavec AS, Soueidan SA, Costigan DA, Wallace DC (1989) Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci USA 86:7952-6
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7952-7956
    • Shoffner, J.M.1    Lott, M.T.2    Voljavec, A.S.3    Soueidan, S.A.4    Costigan, D.A.5    Wallace, D.C.6
  • 47
    • 0034687797 scopus 로고    scopus 로고
    • Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice
    • Sligh JE, Levy SE, Waymire KG et al. (2000) Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice. Proc Natl Acad Sci USA 97:14461-6
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 14461-14466
    • Sligh, J.E.1    Levy, S.E.2    Waymire, K.G.3
  • 48
    • 0025243540 scopus 로고
    • Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes
    • Torroni A, Stepien G, Hodge JA, Wallace DC (1990) Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes. J Biol Chem 265:20589-93
    • (1990) J Biol Chem , vol.265 , pp. 20589-20593
    • Torroni, A.1    Stepien, G.2    Hodge, J.A.3    Wallace, D.C.4
  • 50
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • Wallace DC (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256:628-32
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 52
    • 0033525773 scopus 로고    scopus 로고
    • Mitochondrial diseases in man and mouse
    • Wallace DC (1999) Mitochondrial diseases in man and mouse. Science 283:1482-8
    • (1999) Science , vol.283 , pp. 1482-1488
    • Wallace, D.C.1
  • 53
    • 2542505678 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • Wei YH (1998) Oxidative stress and mitochondrial DNA mutations in human aging. Proc Soc Exp Biol Med 217:53-63
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 53-63
    • Wei, Y.H.1
  • 55
    • 0027963448 scopus 로고
    • A specific 4977-bp deletion of mitochondrial DNA in human ageing skin
    • Yang JH, Lee HC, Lin KJ, Wei YH (1994) A specific 4977-bp deletion of mitochondrial DNA in human ageing skin. Arch Dermatol Res 286:386-90
    • (1994) Arch Dermatol Res , vol.286 , pp. 386-390
    • Yang, J.H.1    Lee, H.C.2    Lin, K.J.3    Wei, Y.H.4
  • 56
    • 0029121602 scopus 로고
    • Photoageing-associated mitochondrial DNA length mutations in human skin
    • Yang JH, Lee HC, Wei YH (1995) Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res 287:641-8
    • (1995) Arch Dermatol Res , vol.287 , pp. 641-648
    • Yang, J.H.1    Lee, H.C.2    Wei, Y.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.