메뉴 건너뛰기




Volumn 56, Issue 10, 2011, Pages 689-694

The generation of mitochondrial DNA large-scale deletions in human cells

Author keywords

generation; large scale deletions; mitochondrial DNA; repair; replication

Indexed keywords

MITOCHONDRIAL DNA;

EID: 80155174769     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2011.97     Document Type: Review
Times cited : (52)

References (61)
  • 1
    • 77955290363 scopus 로고    scopus 로고
    • Evaluating mitochondrial DNA in cancer occurrence and development
    • Shen, L., Fang, H., Chen, T., He, J., Zhang, M., Wei, X. et al. Evaluating mitochondrial DNA in cancer occurrence and development. Ann. NY Acad. Sci. 1201, 26-33 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1201 , pp. 26-33
    • Shen, L.1    Fang, H.2    Chen, T.3    He, J.4    Zhang, M.5    Wei, X.6
  • 3
    • 84857795466 scopus 로고    scopus 로고
    • MITOMAP: A Human Mitochondrial Genome Database.. http://www.mitomap.org (2010).
    • (2010)
  • 4
    • 17744393686 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human disease
    • Taylor, R. W. & Turnbull, D. M. Mitochondrial DNA mutations in human disease. Nat. Rev. Genet. 6, 389-402 (2005).
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 389-402
    • Taylor, R.W.1    Turnbull, D.M.2
  • 5
    • 68149137896 scopus 로고    scopus 로고
    • Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis
    • Lu, J., Sharma, L. K. & Bai, Y. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell. Res. 19, 802-815 (2009).
    • (2009) Cell. Res. , vol.19 , pp. 802-815
    • Lu, J.1    Sharma, L.K.2    Bai, Y.3
  • 6
    • 34047130220 scopus 로고    scopus 로고
    • DNA supercoiling suppresses real-time PCR: A new approach to the quantification of mitochondrial DNA damage and repair
    • Chen, J., Kadlubar, F. F. & Chen, J. Z. DNA supercoiling suppresses real-time PCR: a new approach to the quantification of mitochondrial DNA damage and repair. Nucleic Acids Res. 35, 1377-1388 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. 1377-1388
    • Chen, J.1    Kadlubar, F.F.2    Chen, J.Z.3
  • 7
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • Richter, C., Park, J. W. & Ames, B. N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl Acad. Sci. USA 85, 6465-6467 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 8
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames, B. N., Shigenaga, M. K. & Hagen, T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA 90, 7915-7922 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 9
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • Wallace, D. C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359-407 (2005).
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 10
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • Polyak, K., Li, Y., Zhu, H., Lengauer, C., Willson, J. K., Markowitz, S. D. et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat. Genet. 20, 291-293 (1998).
    • (1998) Nat. Genet. , vol.20 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3    Lengauer, C.4    Willson, J.K.5    Markowitz, S.D.6
  • 11
    • 0039250954 scopus 로고    scopus 로고
    • Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
    • Fliss, M. S., Usadel, H., Caballero, O. L., Wu, L., Buta, M. R., Eleff, S. M. et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 287, 2017-2019 (2000).
    • (2000) Science , vol.287 , pp. 2017-2019
    • Fliss, M.S.1    Usadel, H.2    Caballero, O.L.3    Wu, L.4    Buta, M.R.5    Eleff, S.M.6
  • 12
    • 64549098628 scopus 로고    scopus 로고
    • A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
    • Park, J. S., Sharma, L. K., Li, H., Xiang, R., Holstein, D., Wu, J. et al. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum. Mol. Genet. 18, 1578-1589 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1578-1589
    • Park, J.S.1    Sharma, L.K.2    Li, H.3    Xiang, R.4    Holstein, D.5    Wu, J.6
  • 13
    • 46749100918 scopus 로고    scopus 로고
    • The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?
    • Meissner, C., Bruse, P., Mohamed, S. A., Schulz, A., Warnk, H., Storm, T. et al. The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: a useful biomarker or more? Exp. Gerontol. 43, 645-652 (2008).
    • (2008) Exp. Gerontol. , vol.43 , pp. 645-652
    • Meissner, C.1    Bruse, P.2    Mohamed, S.A.3    Schulz, A.4    Warnk, H.5    Storm, T.6
  • 14
    • 33644647886 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers
    • Eshaghian, A., Vleugels, R. A., Canter, J. A., McDonald, M. A., Stasko, T. & Sligh, J. E. Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers. J. Invest. Dermatol. 126, 336-344 (2006).
    • (2006) J. Invest. Dermatol. , vol.126 , pp. 336-344
    • Eshaghian, A.1    Vleugels, R.A.2    Canter, J.A.3    McDonald, M.A.4    Stasko, T.5    Sligh, J.E.6
  • 16
    • 33646595697 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer
    • Tseng, L. M., Yin, P. H., Chi, C. W., Hsu, C. Y., Wu, C. W., Lee, L. M. et al. Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer 45, 629-638 (2006).
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 629-638
    • Tseng, L.M.1    Yin, P.H.2    Chi, C.W.3    Hsu, C.Y.4    Wu, C.W.5    Lee, L.M.6
  • 17
    • 23044514580 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer
    • Wu, C. W., Yin, P. H., Hung, W. Y., Li, A. F., Li, S. H., Chi, C. W. et al. Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosomes Cancer 44, 19-28 (2005).
    • (2005) Genes Chromosomes Cancer , vol.44 , pp. 19-28
    • Wu, C.W.1    Yin, P.H.2    Hung, W.Y.3    Li, A.F.4    Li, S.H.5    Chi, C.W.6
  • 18
    • 13144295901 scopus 로고    scopus 로고
    • Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma
    • Abnet, C. C., Huppi, K., Carrera, A., Armistead, D., McKenney, K., Hu, N. et al. Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma. BMC Cancer 4, 30 (2004).
    • (2004) BMC Cancer , vol.4 , pp. 30
    • Abnet, C.C.1    Huppi, K.2    Carrera, A.3    Armistead, D.4    McKenney, K.5    Hu, N.6
  • 19
    • 78651281751 scopus 로고    scopus 로고
    • The mitochondrial DNA 4977-bp deletion and its implication in copy number alteration in colorectal cancer
    • Chen, T., He, J., Shen, L., Fang, H., Nie, H., Jin, T. et al. The mitochondrial DNA 4977-bp deletion and its implication in copy number alteration in colorectal cancer. BMC Med. Genet. 12, 8 (2011).
    • (2011) BMC Med. Genet. , vol.12 , pp. 8
    • Chen, T.1    He, J.2    Shen, L.3    Fang, H.4    Nie, H.5    Jin, T.6
  • 20
    • 0024317560 scopus 로고
    • Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy
    • Shoffner, J. M., Lott, M. T., Voljavec, A. S., Soueidan, S. A., Costigan, D. A. & Wallace, D. C. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc. Natl Acad. Sci. USA 86, 7952-7956 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 7952-7956
    • Shoffner, J.M.1    Lott, M.T.2    Voljavec, A.S.3    Soueidan, S.A.4    Costigan, D.A.5    Wallace, D.C.6
  • 22
    • 0024328462 scopus 로고
    • Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome
    • Moraes, C. T., DiMauro, S., Zeviani, M., Lombes, A., Shanske, S., Miranda, A. F. et al. Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome. N. Engl. J. Med. 320, 1293-1299 (1989).
    • (1989) N. Engl. J. Med. , vol.320 , pp. 1293-1299
    • Moraes, C.T.1    DiMauro, S.2    Zeviani, M.3    Lombes, A.4    Shanske, S.5    Miranda, A.F.6
  • 23
    • 0026026191 scopus 로고
    • Different mechanisms inferred from sequences of human mitochondrial DNA deletions in ocular myopathies
    • Degoul, F., Nelson, I., Amselem, S., Romero, N., Obermaier-Kusser, B., Ponsot, G. et al. Different mechanisms inferred from sequences of human mitochondrial DNA deletions in ocular myopathies. Nucleic Acids Res. 19, 493-496 (1991).
    • (1991) Nucleic Acids Res. , vol.19 , pp. 493-496
    • Degoul, F.1    Nelson, I.2    Amselem, S.3    Romero, N.4    Obermaier-Kusser, B.5    Ponsot, G.6
  • 24
    • 0030854939 scopus 로고    scopus 로고
    • Association of myopathy with large-scale mitochondrial DNA duplications and deletions: Which is pathogenic?
    • Manfredi, G., Vu, T., Bonilla, E., Schon, E. A., DiMauro, S., Arnaudo, E. et al. Association of myopathy with large-scale mitochondrial DNA duplications and deletions: which is pathogenic? Ann. Neurol. 42, 180-188 (1997).
    • (1997) Ann. Neurol. , vol.42 , pp. 180-188
    • Manfredi, G.1    Vu, T.2    Bonilla, E.3    Schon, E.A.4    DiMauro, S.5    Arnaudo, E.6
  • 25
    • 1542753508 scopus 로고    scopus 로고
    • Compensatory amplification of mtDNA in a patient with a novel deletion/duplication and high mutant load
    • Wong, L. J., Perng, C. L., Hsu, C. H., Bai, R. K., Schelley, S., Vladutiu, G. D. et al. Compensatory amplification of mtDNA in a patient with a novel deletion/duplication and high mutant load. J. Med. Genet. 40, e125 (2003).
    • (2003) J. Med. Genet. , vol.40
    • Wong, L.J.1    Perng, C.L.2    Hsu, C.H.3    Bai, R.K.4    Schelley, S.5    Vladutiu, G.D.6
  • 26
    • 0024342089 scopus 로고
    • Directly repeated sequences associated with pathogenic mitochondrial DNA deletions
    • Johns, D. R., Rutledge, S. L., Stine, O. C. & Hurko, O. Directly repeated sequences associated with pathogenic mitochondrial DNA deletions. Proc. Natl Acad. Sci. USA. 86, 8059-8062 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 8059-8062
    • Johns, D.R.1    Rutledge, S.L.2    Stine, O.C.3    Hurko, O.4
  • 27
    • 0026849690 scopus 로고
    • Maternally transmitted diabetes and deafness associated with a 10.4kb mitochondrial DNA deletion
    • Ballinger, S. W., Shoffner, J. M., Hedaya, E. V., Trounce, I., Polak, M. A., Koontz, D. A. et al. Maternally transmitted diabetes and deafness associated with a 10.4kb mitochondrial DNA deletion. Nat. Genet. 1, 11-15 (1992).
    • (1992) Nat. Genet. , vol.1 , pp. 11-15
    • Ballinger, S.W.1    Shoffner, J.M.2    Hedaya, E.V.3    Trounce, I.4    Polak, M.A.5    Koontz, D.A.6
  • 28
    • 0024541068 scopus 로고
    • Mitochondrial DNA mutations and neuromuscular disease
    • Wallace, D. C. Mitochondrial DNA mutations and neuromuscular disease. Trends. Genet. 5, 9-13 (1989).
    • (1989) Trends. Genet. , vol.5 , pp. 9-13
    • Wallace, D.C.1
  • 29
    • 0043209312 scopus 로고    scopus 로고
    • Characterisation of repeat and palindrome elements in patients harbouring single deletions of mitochondrial DNA
    • Solano, A., Gamez, J., Carod, F. J., Pineda, M., Playan, A., Lopez-Gallardo, E. et al. Characterisation of repeat and palindrome elements in patients harbouring single deletions of mitochondrial DNA. J. Med. Genet. 40, e86 (2003).
    • (2003) J. Med. Genet. , vol.40
    • Solano, A.1    Gamez, J.2    Carod, F.J.3    Pineda, M.4    Playan, A.5    Lopez-Gallardo, E.6
  • 30
    • 3242777099 scopus 로고    scopus 로고
    • Mitochondrial DNA and human thyroid diseases
    • Rogounovitch, T., Saenko, V. & Yamashita, S. Mitochondrial DNA and human thyroid diseases. Endocr. J. 51, 265-277 (2004).
    • (2004) Endocr. J. , vol.51 , pp. 265-277
    • Rogounovitch, T.1    Saenko, V.2    Yamashita, S.3
  • 31
    • 0028951863 scopus 로고
    • Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome
    • Zhang, C., Baumer, A., Mackay, I. R., Linnane, A. W. & Nagley, P. Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome. Hum. Mol. Genet. 4, 751-754 (1995).
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 751-754
    • Zhang, C.1    Baumer, A.2    Mackay, I.R.3    Linnane, A.W.4    Nagley, P.5
  • 33
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Cortopassi, G. A., Shibata, D., Soong, N. W. & Arnheim, N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl Acad. Sci. USA 89, 7370-7374 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1    Shibata, D.2    Soong, N.W.3    Arnheim, N.4
  • 34
    • 33748643416 scopus 로고    scopus 로고
    • Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers
    • Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S. et al. Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am. J. Hum. Genet. 79, 469-480 (2006).
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 469-480
    • Bua, E.1    Johnson, J.2    Herbst, A.3    Delong, B.4    McKenzie, D.5    Salamat, S.6
  • 35
    • 41149097145 scopus 로고    scopus 로고
    • Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases
    • Ye, C., Shu, X. O., Wen, W., Pierce, L., Courtney, R., Gao, Y. T. et al. Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases. Breast Cancer Res. Treat. 108, 427-434 (2008).
    • (2008) Breast Cancer Res. Treat. , vol.108 , pp. 427-434
    • Ye, C.1    Shu, X.O.2    Wen, W.3    Pierce, L.4    Courtney, R.5    Gao, Y.T.6
  • 36
  • 37
    • 0024596946 scopus 로고
    • A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA
    • Schon, E. A., Rizzuto, R., Moraes, C. T., Nakase, H., Zeviani, M. & DiMauro, S. A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA. Science 244, 346-349 (1989).
    • (1989) Science , vol.244 , pp. 346-349
    • Schon, E.A.1    Rizzuto, R.2    Moraes, C.T.3    Nakase, H.4    Zeviani, M.5    DiMauro, S.6
  • 38
    • 4143081492 scopus 로고    scopus 로고
    • Two direct repeats cause most human mtDNA deletions
    • Samuels, D. C., Schon, E. A. & Chinnery, P. F. Two direct repeats cause most human mtDNA deletions. Trends. Genet. 20, 393-398 (2004).
    • (2004) Trends. Genet. , vol.20 , pp. 393-398
    • Samuels, D.C.1    Schon, E.A.2    Chinnery, P.F.3
  • 39
    • 0019996193 scopus 로고
    • On the formation of spontaneous deletions: The importance of short sequence homologies in the generation of large deletions
    • Albertini, A. M., Hofer, M., Calos, M. P. & Miller, J. H. On the formation of spontaneous deletions: the importance of short sequence homologies in the generation of large deletions. Cell 29, 319-328 (1982).
    • (1982) Cell , vol.29 , pp. 319-328
    • Albertini, A.M.1    Hofer, M.2    Calos, M.P.3    Miller, J.H.4
  • 41
    • 0014690248 scopus 로고
    • Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat
    • Gross, N. J., Getz, G. S. & Rabinowitz, M. Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat. J. Biol. Chem. 244, 1552-1562 (1969).
    • (1969) J. Biol. Chem. , vol.244 , pp. 1552-1562
    • Gross, N.J.1    Getz, G.S.2    Rabinowitz, M.3
  • 42
    • 0015457563 scopus 로고
    • Replication of mitochondrial DNA in mouse L cells and their thymidine kinase-derivatives: Displacement replication on a covalentlyclosed circular template
    • Robberson, D. L. & Clayton, D. A. Replication of mitochondrial DNA in mouse L cells and their thymidine kinase-derivatives: displacement replication on a covalentlyclosed circular template. Proc. Natl Acad. Sci. USA. 69, 3810-3814 (1972).
    • (1972) Proc. Natl Acad. Sci. USA , vol.69 , pp. 3810-3814
    • Robberson, D.L.1    Clayton, D.A.2
  • 43
    • 0019978703 scopus 로고
    • Replication of animal mitochondrial DNA
    • Clayton, D. A. Replication of animal mitochondrial DNA. Cell 28, 693-705 (1982).
    • (1982) Cell , vol.28 , pp. 693-705
    • Clayton, D.A.1
  • 44
    • 0034598918 scopus 로고    scopus 로고
    • Coupled leading-and lagging-strand synthesis of mammalian mitochondrial DNA
    • Holt, I. J., Lorimer, H. E. & Jacobs, H. T. Coupled leading-and lagging-strand synthesis of mammalian mitochondrial DNA. Cell 100, 515-524 (2000).
    • (2000) Cell , vol.100 , pp. 515-524
    • Holt, I.J.1    Lorimer, H.E.2    Jacobs, H.T.3
  • 46
    • 0007662353 scopus 로고
    • Priming of human mitochondrial DNA replication occurs at the light-strand promoter
    • Chang, D. D. & Clayton, D. A. Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc. Natl Acad. Sci. USA 82, 351-355 (1985).
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 351-355
    • Chang, D.D.1    Clayton, D.A.2
  • 47
    • 0036020222 scopus 로고    scopus 로고
    • Base composition at mtDNA boundaries suggests a DNA triple helix model for human mitochondrial DNA large-scale rearrangements
    • Rocher, C., Letellier, T., Copeland, W. C. & Lestienne, P. Base composition at mtDNA boundaries suggests a DNA triple helix model for human mitochondrial DNA large-scale rearrangements. Mol. Genet. Metab. 76, 123-132 (2002).
    • (2002) Mol. Genet. Metab. , vol.76 , pp. 123-132
    • Rocher, C.1    Letellier, T.2    Copeland, W.C.3    Lestienne, P.4
  • 48
    • 0024410144 scopus 로고
    • DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding
    • Welter, C., Dooley, S., Zang, K. D. & Blin, N. DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding. Nucleic Acids Res. 17, 6077-6086 (1989).
    • (1989) Nucleic Acids Res. , vol.17 , pp. 6077-6086
    • Welter, C.1    Dooley, S.2    Zang, K.D.3    Blin, N.4
  • 49
    • 0035805499 scopus 로고    scopus 로고
    • DNA bends in TATA-binding protein-TATA complexes in solution are DNA sequence-dependent
    • Wu, J., Parkhurst, K. M., Powell, R. M., Brenowitz, M. & Parkhurst, L. J. DNA bends in TATA-binding protein-TATA complexes in solution are DNA sequence-dependent. J. Biol. Chem. 276, 14614-14622 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 14614-14622
    • Wu, J.1    Parkhurst, K.M.2    Powell, R.M.3    Brenowitz, M.4    Parkhurst, L.J.5
  • 50
    • 0347695996 scopus 로고    scopus 로고
    • Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone
    • Bowmaker, M., Yang, M. Y., Yasukawa, T., Reyes, A., Jacobs, H. T., Huberman, J. A. et al. Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. J. Biol. Chem. 278, 50961-50969 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 50961-50969
    • Bowmaker, M.1    Yang, M.Y.2    Yasukawa, T.3    Reyes, A.4    Jacobs, H.T.5    Huberman, J.A.6
  • 51
    • 20444428352 scopus 로고    scopus 로고
    • A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA
    • Yasukawa, T., Yang, M. Y., Jacobs, H. T. & Holt, I. J. A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Mol. Cell. 18, 651-662 (2005).
    • (2005) Mol. Cell , vol.18 , pp. 651-662
    • Yasukawa, T.1    Yang, M.Y.2    Jacobs, H.T.3    Holt, I.J.4
  • 52
    • 26944500840 scopus 로고    scopus 로고
    • Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism
    • Brown, T. A., Cecconi, C., Tkachuk, A. N., Bustamante, C. & Clayton, D. A. Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism. Genes. Dev. 19, 2466-2476 (2005).
    • (2005) Genes. Dev. , vol.19 , pp. 2466-2476
    • Brown, T.A.1    Cecconi, C.2    Tkachuk, A.N.3    Bustamante, C.4    Clayton, D.A.5
  • 53
    • 17344372911 scopus 로고    scopus 로고
    • Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans
    • Srivastava, S. & Moraes, C. T. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Hum. Mol. Genet. 14, 893-902 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 893-902
    • Srivastava, S.1    Moraes, C.T.2
  • 54
    • 61849118621 scopus 로고    scopus 로고
    • Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons
    • Fukui, H. & Moraes, C. T. Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum. Mol. Genet. 18, 1028-1036 (2008).
    • (2008) Hum. Mol. Genet. , vol.18 , pp. 1028-1036
    • Fukui, H.1    Moraes, C.T.2
  • 55
    • 0034195218 scopus 로고    scopus 로고
    • Partners and pathwaysrepairing a double-strand break
    • Haber, J. E. Partners and pathwaysrepairing a double-strand break. Trends. Genet. 16, 259-264 (2000).
    • (2000) Trends. Genet. , vol.16 , pp. 259-264
    • Haber, J.E.1
  • 56
    • 0034461607 scopus 로고    scopus 로고
    • Coupled homologous and nonhomologous repair of a doublestrand break preserves genomic integrity in mammalian cells
    • Richardson, C. & Jasin, M. Coupled homologous and nonhomologous repair of a doublestrand break preserves genomic integrity in mammalian cells. Mol. Cell. Biol. 20, 9068-9075 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9068-9075
    • Richardson, C.1    Jasin, M.2
  • 57
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent, D. C., Hoeijmakers, J. H. & Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2, 196-206 (2001).
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 58
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA doublestrand break repair during the mammalian cell cycle
    • Rothkamm, K., Kruger, I., Thompson, L. H. & Lobrich, M. Pathways of DNA doublestrand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23, 5706-5715 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 59
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA doublestrand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H. et al. Homologous recombination and non-homologous end-joining pathways of DNA doublestrand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17, 5497-5508 (1998).
    • (1998) EMBO J. , vol.17 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6
  • 60
    • 0034599981 scopus 로고    scopus 로고
    • Homologous and non-homologous recombination differentially affect DNA damage repair in mice
    • Essers, J., van Steeg, H., de Wit, J., Swagemakers, S. M., Vermeij, M., Hoeijmakers, J. H. et al. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO J. 19, 1703-1710 (2000).
    • (2000) EMBO J. , vol.19 , pp. 1703-1710
    • Essers, J.1    Van Steeg, H.2    De Wit, J.3    Swagemakers, S.M.4    Vermeij, M.5    Hoeijmakers, J.H.6
  • 61
    • 33845518305 scopus 로고    scopus 로고
    • DNA repair in neurons: So if they don't divide what's to repair?
    • Fishel, M. L., Vasko, M. R. & Kelley, M. R. DNA repair in neurons: so if they don't divide what's to repair? Mutat. Res. 614, 24-36 (2007).
    • (2007) Mutat. Res. , vol.614 , pp. 24-36
    • Fishel, M.L.1    Vasko, M.R.2    Kelley, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.