Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

EMBO Journal

Volumn 32, Issue 10, 2013, Pages 1425-1439

  Lin, Weiqiang ^a   Sampathi, Shilpa ^b,f   Dai, Huifang ^a   Liu, Changwei ^a,c   Zhou, Mian ^a   Hu, Jenny ^a   Huang, Qin ^a   Campbell, Judith ^d   Shin Ya, Kazuo ^e   Zheng, Li ^a   Chai, Weihang ^b   Shen, Binghui ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c ZHEJIANG UNIVERSITY   (China)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^e NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aneuploidy; Cancer; DNA2 nuclease; G4; Telomere

Indexed keywords

GUANINE QUADRUPLEX; HELICASE; NUCLEASE;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA DAMAGE; DNA METABOLISM; DNA REPLICATION; DNA STRUCTURE; FEMALE; GENOMIC INSTABILITY; HETEROZYGOTE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; TELOMERE; TETRAPLOIDY;

ADENOCARCINOMA; ANEUPLOIDY; ANIMALS; CHROMOSOME SEGREGATION; DNA DAMAGE; DNA HELICASES; FETAL DEATH; G-QUADRUPLEXES; HOMOZYGOTE; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1; TELOMERIC REPEAT BINDING PROTEIN 2;

MAMMALIA; MUS;

EID: 84878625912     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.88     Document Type: Article

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