-
1
-
-
78751662908
-
The Polycomb complex PRC2 and its mark in life
-
Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011;469:343-9.
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
2
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-26.
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
Kamal, M.4
Huebert, D.J.5
Cuff, J.6
-
3
-
-
34248169728
-
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
-
Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 2007;27:3769-79.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3769-3779
-
-
Pasini, D.1
Bracken, A.P.2
Hansen, J.B.3
Capillo, M.4
Helin, K.5
-
4
-
-
36749082438
-
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
-
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A 2007;104:18439-44.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 18439-18444
-
-
Hong, S.1
Cho, Y.W.2
Yu, L.R.3
Yu, H.4
Veenstra, T.D.5
Ge, K.6
-
5
-
-
35148867907
-
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
-
Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007;449:731-4.
-
(2007)
Nature
, vol.449
, pp. 731-734
-
-
Agger, K.1
Cloos, P.A.2
Christensen, J.3
Pasini, D.4
Rose, S.5
Rappsilber, J.6
-
6
-
-
6844242334
-
The UTX gene escapes X inactivation in mice and humans
-
Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet 1998;7:737-42.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 737-742
-
-
Greenfield, A.1
Carrel, L.2
Pennisi, D.3
Philippe, C.4
Quaderi, N.5
Siggers, P.6
-
7
-
-
84875722648
-
Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells
-
Morales Torres C, Laugesen A, Helin K. Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS ONE 2013;8:e60020.
-
(2013)
PLoS ONE
, vol.8
, pp. e60020
-
-
Morales Torres, C.1
Laugesen, A.2
Helin, K.3
-
8
-
-
51849102077
-
The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment
-
Burgold T, Spreafico F, De Santa F, Totaro MG, Prosperini E, Natoli G, et al. The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS ONE 2008;3:e3034.
-
(2008)
PLoS ONE
, vol.3
, pp. e3034
-
-
Burgold, T.1
Spreafico, F.2
De Santa, F.3
Totaro, M.G.4
Prosperini, E.5
Natoli, G.6
-
10
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003;100:11606-11.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
Shen, R.4
Ota, I.5
Tomlins, S.A.6
-
11
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002;419:624-9.
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
Barrette, T.R.4
Kumar-Sinha, C.5
Sanda, M.G.6
-
12
-
-
84862783103
-
Interrogating genomic and epigenomic data to understand prostate cancer
-
Kim J, Yu J. Interrogating genomic and epigenomic data to understand prostate cancer. Biochim Biophys Acta 2012;1825:186-96.
-
(2012)
Biochim Biophys Acta
, vol.1825
, pp. 186-196
-
-
Kim, J.1
Yu, J.2
-
13
-
-
84871052080
-
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
-
Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012;338:1465-9.
-
(2012)
Science
, vol.338
, pp. 1465-1469
-
-
Xu, K.1
Wu, Z.J.2
Groner, A.C.3
He, H.H.4
Cai, C.5
Lis, R.T.6
-
14
-
-
84879000598
-
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
-
Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 2013;23:839-52.
-
(2013)
Cancer Cell
, vol.23
, pp. 839-852
-
-
Kim, E.1
Kim, M.2
Woo, D.H.3
Shin, Y.4
Shin, J.5
Chang, N.6
-
15
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010;42:181-5.
-
(2010)
Nat Genet
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
Mungall, A.J.4
An, J.5
Goya, R.6
-
16
-
-
84863165348
-
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
-
McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y, et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci U S A 2012;109:2989-94.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 2989-2994
-
-
McCabe, M.T.1
Graves, A.P.2
Ganji, G.3
Diaz, E.4
Halsey, W.S.5
Jiang, Y.6
-
17
-
-
84866597616
-
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
-
Majer CR, Jin L, Scott MP, Knutson SK, Kuntz KW, Keilhack H, et al. A687V EZH2 is a gain-of-function mutation found in lymphoma patients. FEBS Lett 2012;586:3448-51.
-
(2012)
FEBS Lett
, vol.586
, pp. 3448-3451
-
-
Majer, C.R.1
Jin, L.2
Scott, M.P.3
Knutson, S.K.4
Kuntz, K.W.5
Keilhack, H.6
-
18
-
-
84877815031
-
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
-
Beguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 2013;23:677-92.
-
(2013)
Cancer Cell
, vol.23
, pp. 677-692
-
-
Beguelin, W.1
Popovic, R.2
Teater, M.3
Jiang, Y.4
Bunting, K.L.5
Rosen, M.6
-
19
-
-
78650454078
-
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
-
Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM, et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A 2010;107:20980-5.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
Scott, M.P.2
Kuntz, K.W.3
Knutson, S.K.4
Pollock, R.M.5
Richon, V.M.6
-
20
-
-
79952167230
-
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
-
Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011;117:2451-9.
-
(2011)
Blood
, vol.117
, pp. 2451-2459
-
-
Yap, D.B.1
Chu, J.2
Berg, T.3
Schapira, M.4
Cheng, S.W.5
Moradian, A.6
-
21
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010;42:722-6.
-
(2010)
Nat Genet
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
Hidalgo-Curtis, C.E.4
Bryant, C.5
Jones, A.V.6
-
22
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tonnissen ER, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 2010;42:665-7.
-
(2010)
Nat Genet
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.2
Kuiper, R.P.3
Knops, R.4
Massop, M.5
Tonnissen, E.R.6
-
23
-
-
84856747744
-
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
-
Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Flaherty MS, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med 2012;18:298-301.
-
(2012)
Nat Med
, vol.18
, pp. 298-301
-
-
Ntziachristos, P.1
Tsirigos, A.2
Van Vlierberghe, P.3
Nedjic, J.4
Trimarchi, T.5
Flaherty, M.S.6
-
24
-
-
79960227474
-
Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
-
Abdel-Wahab O, Pardanani A, Patel J, Wadleigh M, Lasho T, Heguy A, et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia 2011;25:1200-2.
-
(2011)
Leukemia
, vol.25
, pp. 1200-1202
-
-
Abdel-Wahab, O.1
Pardanani, A.2
Patel, J.3
Wadleigh, M.4
Lasho, T.5
Heguy, A.6
-
25
-
-
79959794787
-
Clinical effect of point mutations in myelodysplastic syndromes
-
Bejar R, Stevenson K, Abdel-Wahab O, Galili N, Nilsson B, Garcia-Manero G, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med 2011;364:2496-506.
-
(2011)
N Engl J Med
, vol.364
, pp. 2496-2506
-
-
Bejar, R.1
Stevenson, K.2
Abdel-Wahab, O.3
Galili, N.4
Nilsson, B.5
Garcia-Manero, G.6
-
26
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012;366:1079-89.
-
(2012)
N Engl J Med
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
-
27
-
-
84888083126
-
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
-
Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, et al. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med 2013;210:2627-39.
-
(2013)
J Exp Med
, vol.210
, pp. 2627-2639
-
-
Muto, T.1
Sashida, G.2
Oshima, M.3
Wendt, G.R.4
Mochizuki-Kashio, M.5
Nagata, Y.6
-
28
-
-
84857042600
-
Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms
-
Brecqueville M, Cervera N, Adelaide J, Rey J, Carbuccia N, Chaffanet M, et al. Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms. Blood Cancer J 2011;1:e33.
-
(2011)
Blood Cancer J
, vol.1
, pp. e33
-
-
Brecqueville, M.1
Cervera, N.2
Adelaide, J.3
Rey, J.4
Carbuccia, N.5
Chaffanet, M.6
-
29
-
-
84861702964
-
Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms
-
Brecqueville M, Rey J, Bertucci F, Coppin E, Finetti P, Carbuccia N, et al. Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes Chromosomes Cancer 2012;51:743-55.
-
(2012)
Genes Chromosomes Cancer
, vol.51
, pp. 743-755
-
-
Brecqueville, M.1
Rey, J.2
Bertucci, F.3
Coppin, E.4
Finetti, P.5
Carbuccia, N.6
-
30
-
-
84856596417
-
Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
-
Score J, Hidalgo-Curtis C, Jones AV, Winkelmann N, Skinner A, Ward D, et al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. Blood 2012;119:1208-13.
-
(2012)
Blood
, vol.119
, pp. 1208-1213
-
-
Score, J.1
Hidalgo-Curtis, C.2
Jones, A.V.3
Winkelmann, N.4
Skinner, A.5
Ward, D.6
-
31
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
-
Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 2012;22:180-93.
-
(2012)
Cancer Cell
, vol.22
, pp. 180-193
-
-
Abdel-Wahab, O.1
Adli, M.2
LaFave, L.M.3
Gao, J.4
Hricik, T.5
Shih, A.H.6
-
32
-
-
77952421834
-
Frequent mutation of the polycombassociated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
-
Boultwood J, Perry J, Pellagatti A, Fernandez-Mercado M, Fernandez-Santamaria C, Calasanz MJ, et al. Frequent mutation of the polycombassociated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia 2010;24:1062-5.
-
(2010)
Leukemia
, vol.24
, pp. 1062-1065
-
-
Boultwood, J.1
Perry, J.2
Pellagatti, A.3
Fernandez-Mercado, M.4
Fernandez-Santamaria, C.5
Calasanz, M.J.6
-
33
-
-
84887462456
-
Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations
-
Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, et al. Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest 2013;123:4627-40.
-
(2013)
J Clin Invest
, vol.123
, pp. 4627-4640
-
-
Inoue, D.1
Kitaura, J.2
Togami, K.3
Nishimura, K.4
Enomoto, Y.5
Uchida, T.6
-
34
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012;2:401-4.
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
Gross, B.E.4
Sumer, S.O.5
Aksoy, B.A.6
-
35
-
-
84908396308
-
-
Available from
-
Cbioportal.org. cBioPortal for Cancer Genomics. 2014 Available from: http://www.cbioportal.org/public-portal/
-
(2014)
CBioPortal for Cancer Genomics
-
-
-
37
-
-
80052266351
-
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
-
Gui Y, Guo G, Huang Y, Hu X, Tang A, Gao S, et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet 2011;43:875-8.
-
(2011)
Nat Genet
, vol.43
, pp. 875-878
-
-
Gui, Y.1
Guo, G.2
Huang, Y.3
Hu, X.4
Tang, A.5
Gao, S.6
-
38
-
-
84893786820
-
Advanced urothelial carcinoma: Next-generation sequencing reveals diverse genomic alterations and targets of therapy
-
Ross JS, Wang K, Al-Rohil RN, Nazeer T, Sheehan CE, Otto GA, et al. Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy. Mod Pathol 2014;27:271-80.
-
(2014)
Mod Pathol
, vol.27
, pp. 271-280
-
-
Ross, J.S.1
Wang, K.2
Al-Rohil, R.N.3
Nazeer, T.4
Sheehan, C.E.5
Otto, G.A.6
-
39
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009;41:521-3.
-
(2009)
Nat Genet
, vol.41
, pp. 521-523
-
-
Van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
Chen, L.4
Bignell, G.5
Greenman, C.6
-
40
-
-
84879689007
-
The mutational landscape of adenoid cystic carcinoma
-
Ho AS, Kannan K, Roy DM, Morris LG, Ganly I, Katabi N, et al. The mutational landscape of adenoid cystic carcinoma. Nat Genet 2013;45:791-8.
-
(2013)
Nat Genet
, vol.45
, pp. 791-798
-
-
Ho, A.S.1
Kannan, K.2
Roy, D.M.3
Morris, L.G.4
Ganly, I.5
Katabi, N.6
-
41
-
-
76749139057
-
The histone demethylase UTX enables RB-dependent cell fate control
-
Wang JK, Tsai MC, Poulin G, Adler AS, Chen S, Liu H, et al. The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev 2010;24:327-32.
-
(2010)
Genes Dev
, vol.24
, pp. 327-332
-
-
Wang, J.K.1
Tsai, M.C.2
Poulin, G.3
Adler, A.S.4
Chen, S.5
Liu, H.6
-
42
-
-
84896536423
-
UTX and MLL4 Coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
-
Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, et al. UTX and MLL4 Coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res 2014;74:1705-17.
-
(2014)
Cancer Res
, vol.74
, pp. 1705-1717
-
-
Kim, J.H.1
Sharma, A.2
Dhar, S.S.3
Lee, S.H.4
Gu, B.5
Chan, C.H.6
-
43
-
-
84884589668
-
Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells
-
Chapman-Rothe N, Curry E, Zeller C, Liber D, Stronach E, Gabra H, et al. Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells. Oncogene 2013;32:4586-92.
-
(2013)
Oncogene
, vol.32
, pp. 4586-4592
-
-
Chapman-Rothe, N.1
Curry, E.2
Zeller, C.3
Liber, D.4
Stronach, E.5
Gabra, H.6
-
44
-
-
77951980558
-
The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila
-
Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, et al. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol 2010;30:2485-97.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 2485-2497
-
-
Herz, H.M.1
Madden, L.D.2
Chen, Z.3
Bolduc, C.4
Buff, E.5
Gupta, R.6
-
45
-
-
80053135096
-
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
-
Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011;118:3932-41.
-
(2011)
Blood
, vol.118
, pp. 3932-3941
-
-
Jankowska, A.M.1
Makishima, H.2
Tiu, R.V.3
Szpurka, H.4
Huang, Y.5
Traina, F.6
-
46
-
-
84862777410
-
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
-
Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 2012;44:251-3.
-
(2012)
Nat Genet
, vol.44
, pp. 251-253
-
-
Wu, G.1
Broniscer, A.2
McEachron, T.A.3
Lu, C.4
Paugh, B.S.5
Becksfort, J.6
-
47
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012;482:226-31.
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
Korshunov, A.2
Liu, X.Y.3
Jones, D.T.4
Pfaff, E.5
Jacob, K.6
-
48
-
-
84877299145
-
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
-
Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev 2013;27:985-90.
-
(2013)
Genes Dev
, vol.27
, pp. 985-990
-
-
Chan, K.M.1
Fang, D.2
Gan, H.3
Hashizume, R.4
Yu, C.5
Schroeder, M.6
-
49
-
-
84865863019
-
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
-
Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol 2012;124:439-47.
-
(2012)
Acta Neuropathol
, vol.124
, pp. 439-447
-
-
Khuong-Quang, D.A.1
Buczkowicz, P.2
Rakopoulos, P.3
Liu, X.Y.4
Fontebasso, A.M.5
Bouffet, E.6
-
50
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012;22:425-37.
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
Witt, H.2
Hovestadt, V.3
Khuong-Quang, D.A.4
Jones, D.T.5
Konermann, C.6
-
51
-
-
84877785024
-
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
-
Lewis PW, Muller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 2013;340:857-61.
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.W.1
Muller, M.M.2
Koletsky, M.S.3
Cordero, F.4
Lin, S.5
Banaszynski, L.A.6
-
52
-
-
84887617868
-
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression inK27Mmutant pediatric high-grade gliomas
-
Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 2013;24:660-72.
-
(2013)
Cancer Cell
, vol.24
, pp. 660-672
-
-
Bender, S.1
Tang, Y.2
Lindroth, A.M.3
Hovestadt, V.4
Jones, D.T.5
Kool, M.6
-
53
-
-
84877621282
-
Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN
-
Bjerke L, Mackay A, Nandhabalan M, Burford A, Jury A, Popov S, et al. Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov 2013;3:512-19.
-
(2013)
Cancer Discov
, vol.3
, pp. 512-519
-
-
Bjerke, L.1
Mackay, A.2
Nandhabalan, M.3
Burford, A.4
Jury, A.5
Popov, S.6
-
54
-
-
84888353557
-
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
-
Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet 2013;45:1479-82.
-
(2013)
Nat Genet
, vol.45
, pp. 1479-1482
-
-
Behjati, S.1
Tarpey, P.S.2
Presneau, N.3
Scheipl, S.4
Pillay, N.5
Van Loo, P.6
-
55
-
-
84865279783
-
Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3
-
Zheng Y, Sweet SM, Popovic R, Martinez-Garcia E, Tipton JD, Thomas PM, et al. Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proc Natl Acad Sci U S A 2012;109:13549-54.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 13549-13554
-
-
Zheng, Y.1
Sweet, S.M.2
Popovic, R.3
Martinez-Garcia, E.4
Tipton, J.D.5
Thomas, P.M.6
-
56
-
-
79953143753
-
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation
-
Yuan W, Xu M, Huang C, Liu N, Chen S, Zhu B. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem 2011;286:7983-9.
-
(2011)
J Biol Chem
, vol.286
, pp. 7983-7989
-
-
Yuan, W.1
Xu, M.2
Huang, C.3
Liu, N.4
Chen, S.5
Zhu, B.6
-
57
-
-
84871204903
-
EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms
-
Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, et al. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 2012;26:2557-60.
-
(2012)
Leukemia
, vol.26
, pp. 2557-2560
-
-
Ueda, T.1
Sanada, M.2
Matsui, H.3
Yamasaki, N.4
Honda, Z.I.5
Shih, L.Y.6
-
58
-
-
84878921669
-
Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies
-
Khan SN, Jankowska AM, Mahfouz R, Dunbar AJ, Sugimoto Y, Hosono N, et al. Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies. Leukemia 2013;27:1301-9.
-
(2013)
Leukemia
, vol.27
, pp. 1301-1309
-
-
Khan, S.N.1
Jankowska, A.M.2
Mahfouz, R.3
Dunbar, A.J.4
Sugimoto, Y.5
Hosono, N.6
-
59
-
-
82755176823
-
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27
-
Zhang Y, Yang X, Gui B, Xie G, Zhang D, Shang Y, et al. Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27. J Biol Chem 2011;286:42414-25.
-
(2011)
J Biol Chem
, vol.286
, pp. 42414-42425
-
-
Zhang, Y.1
Yang, X.2
Gui, B.3
Xie, G.4
Zhang, D.5
Shang, Y.6
-
60
-
-
57049167675
-
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation
-
Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, et al. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell 2008;32:718-26.
-
(2008)
Mol Cell
, vol.32
, pp. 718-726
-
-
Mulligan, P.1
Westbrook, T.F.2
Ottinger, M.3
Pavlova, N.4
Chang, B.5
Macia, E.6
-
61
-
-
84856523538
-
CBX7 is a tumor suppressor in mice and humans
-
Forzati F, Federico A, Pallante P, Abbate A, Esposito F, Malapelle U, et al. CBX7 is a tumor suppressor in mice and humans. J Clin Invest 2012;122:612-23.
-
(2012)
J Clin Invest
, vol.122
, pp. 612-623
-
-
Forzati, F.1
Federico, A.2
Pallante, P.3
Abbate, A.4
Esposito, F.5
Malapelle, U.6
-
62
-
-
84876485242
-
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
-
Klauke K, Radulovic V, Broekhuis M, Weersing E, Zwart E, Olthof S, et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol 2013;15:353-62.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 353-362
-
-
Klauke, K.1
Radulovic, V.2
Broekhuis, M.3
Weersing, E.4
Zwart, E.5
Olthof, S.6
-
63
-
-
20844463416
-
Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients
-
Keats JJ, Maxwell CA, Taylor BJ, Hendzel MJ, Chesi M, Bergsagel PL, et al. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood 2005;105:4060-9.
-
(2005)
Blood
, vol.105
, pp. 4060-4069
-
-
Keats, J.J.1
Maxwell, C.A.2
Taylor, B.J.3
Hendzel, M.J.4
Chesi, M.5
Bergsagel, P.L.6
-
64
-
-
78650978001
-
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
-
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, et al. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood 2011;117:211-20.
-
(2011)
Blood
, vol.117
, pp. 211-220
-
-
Martinez-Garcia, E.1
Popovic, R.2
Min, D.J.3
Sweet, S.M.4
Thomas, P.M.5
Zamdborg, L.6
-
65
-
-
84879414983
-
The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
-
Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene 2013;32:2882-90.
-
(2013)
Oncogene
, vol.32
, pp. 2882-2890
-
-
Ezponda, T.1
Popovic, R.2
Shah, M.Y.3
Martinez-Garcia, E.4
Zheng, Y.5
Min, D.J.6
-
66
-
-
84886937976
-
MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation
-
Popovic R, Martinez E, Zhang Q, Ezponda T, Jiang Y, Shah MY, et al. MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation. ASH Annual Meeting Abstracts 2012;120:523.
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, pp. 523
-
-
Popovic, R.1
Martinez, E.2
Zhang, Q.3
Ezponda, T.4
Jiang, Y.5
Shah, M.Y.6
-
67
-
-
84891861309
-
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies
-
Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, et al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia 2014;28:198-201.
-
(2014)
Leukemia
, vol.28
, pp. 198-201
-
-
Oyer, J.A.1
Huang, X.2
Zheng, Y.3
Shim, J.4
Ezponda, T.5
Carpenter, Z.6
-
68
-
-
84887108791
-
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
-
Jaffe JD, Wang Y, Chan HM, Zhang J, Huether R, Kryukov GV, et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet 2013;45:1386-91.
-
(2013)
Nat Genet
, vol.45
, pp. 1386-1391
-
-
Jaffe, J.D.1
Wang, Y.2
Chan, H.M.3
Zhang, J.4
Huether, R.5
Kryukov, G.V.6
-
69
-
-
84887285547
-
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
-
Bea S, Valdes-Mas R, Navarro A, Salaverria I, Martin-Garcia D, Jares P, et al. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A 2013;110:18250-5.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 18250-18255
-
-
Bea, S.1
Valdes-Mas, R.2
Navarro, A.3
Salaverria, I.4
Martin-Garcia, D.5
Jares, P.6
-
70
-
-
34347392874
-
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
-
Wang GG, Cai L, Pasillas MP, Kamps MP. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol 2007;9:804-12.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 804-812
-
-
Wang, G.G.1
Cai, L.2
Pasillas, M.P.3
Kamps, M.P.4
-
71
-
-
77957955244
-
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
-
Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, et al. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell 2010;18:316-28.
-
(2010)
Cancer Cell
, vol.18
, pp. 316-328
-
-
Wilson, B.G.1
Wang, X.2
Shen, X.3
McKenna, E.S.4
Lemieux, M.E.5
Cho, Y.J.6
-
72
-
-
84870573126
-
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
-
McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012;492:108-12.
-
(2012)
Nature
, vol.492
, pp. 108-112
-
-
McCabe, M.T.1
Ott, H.M.2
Ganji, G.3
Korenchuk, S.4
Thompson, C.5
Van Aller, G.S.6
-
73
-
-
84884532954
-
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
-
Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 2013;9:643-50.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 643-650
-
-
Kim, W.1
Bird, G.H.2
Neff, T.3
Guo, G.4
Kerenyi, M.A.5
Walensky, L.D.6
-
74
-
-
84921318899
-
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
-
Knutson SK, Kawano S, Minoshima Y, Warholic NM, Huang KC, Xiao Y, et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther 2014;13:842-54.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 842-854
-
-
Knutson, S.K.1
Kawano, S.2
Minoshima, Y.3
Warholic, N.M.4
Huang, K.C.5
Xiao, Y.6
-
75
-
-
84877324084
-
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
-
Knutson SK, Warholic NM, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A 2013;110:7922-7.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 7922-7927
-
-
Knutson, S.K.1
Warholic, N.M.2
Wigle, T.J.3
Klaus, C.R.4
Allain, C.J.5
Raimondi, A.6
-
76
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012;488:404-8.
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
-
77
-
-
84874116695
-
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
-
James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 2013;9:184-91.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 184-191
-
-
James, L.I.1
Barsyte-Lovejoy, D.2
Zhong, N.3
Krichevsky, L.4
Korboukh, V.K.5
Herold, J.M.6
|