The histone demethylase UTX enables RB-dependent cell fate control

Genes and Development

Volumn 24, Issue 4, 2010, Pages 327-332

  Wang, Jordon K ^a   Tsai, Miao Chih ^a   Poulin, Gino ^b   Adler, Adam S ^a   Chen, Shuzhen ^c,d   Liu, Helen ^a   Shi, Yang ^c,d   Chang, Howard Y ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Cancer; Chromatin; Epigenetics; Gene regulation; Histone demethylation

Indexed keywords

HISTONE; HISTONE DEMETHYLASE; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL CYCLE ARREST; CELL FATE; CHROMATIN; CONTROLLED STUDY; DNA MODIFICATION; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GENE TARGETING; GENETIC CODE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN; GENE EXPRESSION REGULATION; GENOME; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; METHYLATION; MICE; NEOPLASMS; RETINOBLASTOMA BINDING PROTEINS;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 76749139057     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1882610     Document Type: Article

References (35)

1. Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K. 2007. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449: 731-734.
2. Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K. 2009. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes & Dev 23: 1171-1176.
3. Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M, Maertens G, Banck M, Zhou MM, Walsh MJ, et al. 2009. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes & Dev 23: 1177-1182.
4. Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. 2003. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 22: 5323-5335.
5. Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. 2006. Genomewide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Dev 20: 1123-1136.
6. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Monch K, Minucci S, Porse BT, Marine JC, et al. 2007. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes & Dev 21: 525-530.
7. Burkhart DL, Sage J. 2008. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8: 671-682.
8. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, et al. 2005. A networkbased analysis of systemic inflammation in humans. Nature 437: 1032-1037.
9. Ceol CJ, Horvitz HR. 2004. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HATcomplex as a negative regulator of Ras signaling. Dev Cell 6: 563-576.
10. Fay DS, Yochem J. 2007. The SynMuv genes of Caenorhabditis elegans in vulval development and beyond. Dev Biol 306: 1-9.
11. Ferguson EL, Horvitz HR. 1989. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Genetics 123: 109-121.
12. Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, Mazo A, Eisenbach L, Canaani E. 2007. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol 27: 1889-1903.
13. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK, Hermanson O, Rosenfeld MG. 2007. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450: 415-419.
14. Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, et al. 2008. Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res 18: 393-403.
15. Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, et al. 2003. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci 100: 11606-11611.
16. Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. 2007. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4α tumor suppressor gene. Genes & Dev 21: 49-54.
17. Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, et al. 2007. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 449: 689-694.
18. Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R. 2007. Demethylation of H3K27 regulates Polycomb recruitment and H2A ubiquitination. Science 318: 447-450.
19. Liu H, Adler AS, Segal E, Chang HY. 2007. A transcriptional program mediating entry into cellular quiescence. PLoS Genet 3: e91. doi: 10.1371/journal.pgen.0030091.
20. Morishita H, Yagi T. 2007. Protocadherin family: Diversity, structure, and function. Curr Opin Cell Biol 19: 584-592.
21. Olender T, Lancet D, Nebert DW. 2008. Update on the olfactory receptor (OR) gene superfamily. Hum Genomics 3: 87-97.
22. Paulson KE, Rieger-Christ K, McDevitt MA, Kuperwasser C, Kim J, Unanue VE, Zhang X, Hu M, Ruthazer R, Berasi SP, et al. 2007. Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. Cancer Res 67: 6136-6145.
23. Rando OJ, Chang HY. 2009. Genome-wide views of chromatin structure. Annu Rev Biochem 78: 245-271.
24. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, et al. 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129: 1311-1323.
25. Ruthenburg AJ, Allis CD, Wysocka J. 2007. Methylation of lysine 4 on histone H3: Intricacy of writing and reading a single epigenetic mark. Mol Cell 25: 15-30.
26. Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424: 223-228.
27. Segal E, Friedman N, Koller D, Regev A. 2004. A module map showing conditional activity of expression modules in cancer. Nat Genet 36: 1090-1098.
28. Sen GL, Webster DE, Barragan DI, Chang HY, Khavari PA. 2008. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes & Dev 22: 1865-1870.
29. Shaw T, Martin P. 2009. Epigenetic reprogramming during wound healing: Loss of Polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep 10: 881-886.
30. Solari F, Ahringer J. 2000. NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr Biol 10: 223-226.
31. Sparmann A, van Lohuizen M. 2006. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6: 846-856.
32. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. 2005. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci 102: 15545-15550.
33. Tevosian SG, Shih HH, Mendelson KG, Sheppard KA, Paulson KE, Yee AS. 1997. HBP1: A HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes & Dev 11: 383-396.
34. van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, et al. 2009. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 41: 521-523.
35. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, et al. 2002. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624-629.