The mitochondrial complex I inhibitor rotenone induces endoplasmic reticulum stress and activation of GSK-3ß in cultured rat retinal cells

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 9, 2014, Pages 5616-5628

  Han, Guoge ^a,b   Casson, Robert J ^a,b   Chidlow, Glyn ^a,b   Wood, John P M ^a,b  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

ATP; Calpain; ER Stress; GSK 3 ; Rotenone

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ADENOSINE TRIPHOSPHATE; BETA ACTIN; GLUCOSE REGULATED PROTEIN 78; GLYCOGEN SYNTHASE KINASE 3 BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PANCREATIC ENDOPLASMIC RETICULUM KINASE; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; ROTENONE; UNCLASSIFIED DRUG; CALPAIN; GLYCOGEN SYNTHASE KINASE 3; UNCOUPLING PROTEIN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL SIGNALING ASSAY; CELL VIABILITY ASSAY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; IMMUNOCYTOCHEMISTRY; NICK END LABELING; NONHUMAN; PATHOGENESIS; QUANTITATIVE ASSAY; RAT; RETINA CELL; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; DISEASE MODEL; DRUG EFFECT; GSK-3Β; IMMUNOHISTOCHEMISTRY; METABOLISM; RETINA NERVE CELL;

ATP; CALPAIN; ER STRESS; GSK-3Β; ROTENONE;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; GLYCOGEN SYNTHASE KINASE 3; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; RATS; REACTIVE OXYGEN SPECIES; RETINAL NEURONS; ROTENONE; UNCOUPLING AGENTS;

EID: 84908105412     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-14371     Document Type: Article

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