Calpain inhibitors and antioxidants act synergistically to prevent cell necrosis: Effects of the novel dual inhibitors (cysteine protease inhibitor and antioxidant) BN 82204 and its pro-drug BN 82270

Journal of Neurochemistry

Volumn 98, Issue 4, 2006, Pages 1217-1228

  Pignol, Bernadette ^a   Auvin, Serge ^a   Carré, Denis ^a   Marin, Jean Grégoire ^a   Chabrier, Pierre Etienne ^a  

^a IPSEN   (France)

Author keywords

Antioxidant; C6 and SHSY5Y cells; Calpain; Cathepsin; Maitotoxin; Synergistic protection

Indexed keywords

3 [[N (10H PHENOTHIAZIN 2 YLCARBONYL)LEUCYL]AMINO]TETRAHYDROFURAN 2 YL; 3 [[N (10H PHENOTHIAZIN 2 YLCARBONYL)LEUCYL]AMINO]TETRAHYDROFURAN 2 YL ACETATE; ANTIOXIDANT; BN 82204; BN 82270; CALPAIN; CALPASTATIN; MAITOTOXIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENTIATION; ENZYME ACTIVITY; GLIOMA CELL; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CALPAIN; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; DINOPROST; DRUG SYNERGISM; HUMANS; LIPID PEROXIDATION; METHOTREXATE; NECROSIS; NUCLEIC ACID SYNTHESIS INHIBITORS; PHENOTHIAZINES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SERINE ENDOPEPTIDASES;

EID: 33746409694     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03952.x     Document Type: Article

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