Curcumin ameliorates reserpine-induced pain-depression dyad: Behavioural, biochemical, neurochemical and molecular evidences

Psychoneuroendocrinology

Volumn 36, Issue 10, 2011, Pages 1570-1581

  Arora, V ^a   Kuhad, A ^a   Tiwari, V ^a   Chopra, K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Allodynia; Biogenic amines; Pain depression dyad; Substance P

Indexed keywords

CASPASE 3; CATALASE; CURCUMIN; DOPAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NITRITE; NORADRENALIN; RESERPINE; SEROTONIN; SUBSTANCE P; SUPEROXIDE DISMUTASE; THIOL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; FORCED SWIMMING TEST; HIPPOCAMPUS; IMMOBILIZATION; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NITROSATIVE STRESS; NONHUMAN; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; CURCUMIN; DEPRESSION; MALE; MODELS, BIOLOGICAL; MOLECULAR DIAGNOSTIC TECHNIQUES; NEUROCHEMISTRY; PAIN; RATS; RATS, WISTAR; RESERPINE;

EID: 80054871119     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2011.04.012     Document Type: Article

References (73)

1. Arnow B.A., Hunkeler E.M., Blasey C.M., Lee J., Constantino M.J., Fireman B., Kraemer H.C., Dea R., Robinson R., Hayward C. Comorbid depression, chronic pain, and disability in primary care. Psychosom. Med. 2006, 68:262-268.
2. Bagis S., Tamer L., Sahin G., Bilgin R., Guler H., Ercan B., Erdogan C. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder?. Rheumatol. Int. 2005, 25:188-190.
3. Bair M.J., Robinson R.L., Eckert G.J., Stang P.E., Croghan T.W., Kroenke K. Impact of pain on depression treatment response in primary care. Psychosom. Med. 2004, 66:17-22.
4. Bair M.J., Robinson R.L., Katon W., Kroenke K. Depression and pain comorbidity: a literature review. Arch. Intern. Med. 2003, 163:2433-2445.
5. Bharti A.C., Donato N., Singh S., Aggarwal B.B. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2003, 101:1053-1062.
6. Bhutani M.K., Bishnoi M., Kulkarni S.K. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol. Biochem. Behav. 2009, 92:39-43.
7. Bierhaus A., Schiekofer S., Schwaninger M., Andrassy M., Humpert P.M., Chen J., Hong M., Luther T., Henle T., Kloting I., Morcos M., Hofmann M., Tritschler H., Weigle B., Kasper M., Smith M., Perry G., Schmidt A.M., Stern D.M., Haring H.U., Schleicher E., Nawroth P.P. Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 2001, 50:2792-2808.
8. Bilici M., Efe H., Koroglu M.A., Uydu H.A., Bekaroglu M., Deger O. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J. Affect Disord. 2001, 64:43-51.
9. Bilska A., Dubiel M., Sokolowska-Jezewicz M., Lorenc-Koci E., Wlodek L. Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience 2007, 146:1758-1771.
10. Blier P., Gobbi G., Haddjeri N., Santarelli L., Mathew G., Hen R. Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response. J. Psychiatry Neurosci. 2004, 29:208-218.
11. Campbell L.C., Clauw D.J., Keefe F.J. Persistent pain and depression: a biopsychosocial perspective. Biol. Psychiatry 2003, 54:399-409.
12. Cho J.W., Lee K.S., Kim C.W. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int. J. Mol. Med. 2007, 19:469-474.
13. Chopra K., Tiwari V., Arora V., Kuhad A. Sesamol suppresses neuro-inflammatory cascade in experimental model of diabetic neuropathy. J. Pain 2010, 11:950-957.
14. Claiborne A. Catalase activity. Handbook of Methods for Oxygen Radical Research 1985, 283-284. CRC Press, Boca Raton. R.A. Greenwald (Ed.).
15. Cordero M.D., Moreno-Fernandez A.M., Demiguel M., Bonal P., Campa F., Jimenez-Jimenez L.M., Ruiz-Losada A., Sanchez-Dominguez B., Alcazar J.A.S., Salviati L., Navas P. Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin. Biochem. 2009, 42:732-735.
16. Dersh J., Polatin P.B., Gatchel R.J. Chronic pain and psychopathology: research findings and theoretical considerations. Psychosom. Med. 2002, 64:773-786.
17. Dohare P., Garg P., Jain V., Nath C., Ray M. Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. Behav. Brain Res. 2008, 193:289-297.
18. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., Lanctot K.L. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67:446-457.
19. Elhwuegi A.S. Central monoamines and their role in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2004, 28:435-451.
20. Ferrer-Garcia M.D., Wernicke J.F., Detke M.J., Iyengar S. The depression-pain complex: overlap between the two problems and implications for neuropathic pain 2006, 307-325. IASP Press, Seattle. J.N. Campbell, A.I. Basbaum, A. Dray, R. Dubner, R.H. Dworkin, C.N. Sang (Eds.).
21. Fishbain D.A., Cutler R., Rosomoff H.L., Rosomoff R.S. Chronic pain-associated depression: antecedent or consequence of chronic pain? A review. Clin. J. Pain 1997, 13:116-137.
22. Goldenberg D.L. Pain/depression dyad: a key to a better understanding and treatment of functional somatic syndromes. Am. J. Med. 2010, 123:675-682.
23. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 1982, 126:131-138.
24. Gureje O., Von Korff M., Simon G.E., Gater R. Persistent pain and well-being: a World Health Organization Study in Primary Care. JAMA 1998, 280:147-151.
25. Hein G., Franke S. Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia?. Rheumatology (Oxford) 2002, 41:1163-1167.
26. Herken H., Gurel A., Selek S., Armutcu F., Ozen M.E., Bulut M., Kap O., Yumru M., Savas H.A., Akyol O. Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment. Arch. Med. Res. 2007, 38:247-252.
27. Huang Q.J., Jiang H., Hao X.L., Minor T.R. Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats. Acta Pharmacol. Sin. 2004, 25:293-296.
28. Jackson K.C., St Onge E.L. Antidepressant pharmacotherapy: considerations for the pain clinician. Pain Pract. 2003, 3:135-143.
29. Jain S.K., Rains J., Croad J., Larson B., Jones K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid. Redox. Signal. 2009, 11:241-249.
30. Jollow D.J., Mitchell J.R., Zampaglione N., Gillette J.R. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974, 11:151-169.
31. Joseph E.K., Levine J.D. Caspase signalling in neuropathic and inflammatory pain in the rat. Eur. J. Neurosci. 2004, 20:2896-2902.
32. Kadetoff D., Lampa J., Westman M., Gillis-Haegerstrand C. CNS inflammation in fibromyalgia-cerebrospinal production of TNF-alpha is related to fatigue and IL-8 to fibromyalgia impact. Eur. J. Pain 2009, 13:S150.
33. Khanzode S.D., Dakhale G.N., Khanzode S.S., Saoji A., Palasodkar R. Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox. Rep. 2003, 8:365-370.
34. Kislinger T., Fu C.F., Huber B., Qu W., Taguchi A., Yan S.D., Hofmann M., Yan S.F., Pischetsrieder M., Stern D., Schmidt A.M. N-epsilon-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J. Biol. Chem. 1999, 274:31740-31749.
35. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch. Biochem. Biophys. 1978, 186:189-195.
36. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G., Snavely D., Wyatt-Knowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., Rupniak N.M. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998, 281:1640-1645.
37. Kulkarni S.K., Bhutani M.K., Bishnoi M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl) 2008, 201:435-442.
38. Kulkarni S.K., Robert R.K. Reversal by serotonergic agents of reserpine-induced hyperalgesia in rats. Eur. J. Pharmacol. 1982, 83:325-328.
39. Kundermann B., Hemmeter-Spernal J., Strate P., Gebhardt S., Huber M.T., Krieg J.C., Lautenbacher S. Pain sensitivity in major depression and its relationship to central serotoninergic function as reflected by the neuroendocrine response to clomipramine. J. Psychiatr. Res. 2009, 43:1253-1261.
40. Landi F., Onder G., Cesari M., Russo A., Barillaro C., Bernabei R. Pain and its relation to depressive symptoms in frail older people living in the community: an observational study. J. Pain Symptom Manage. 2005, 29:255-262.
41. Larson A.A., Giovengo S.L., Russell I.J., Michalek J.E. Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways. Pain 2000, 87:201-211.
42. Lindsay P.G., Wyckoff M. The depression-pain syndrome and its response to antidepressants. Psychosomatics 1981, 22(571-3):576-577.
43. Lohr J.B., Kuczenski R., Niculescu A.B. Oxidative mechanisms and tardive dyskinesia. CNS drugs 2003, 17:47-62.
44. Maes M., Mihaylova I., Kubera M., Uytterhoeven M., Vrydags N., Bosmans E. Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease. J. Affect. Disord. 2010, 125:287-294.
45. Malmberg A.B., Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992, 257:1276-1279.
46. Mehla J., Reeta K.H., Gupta P., Gupta Y.K. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci. 2010, 87:596-603.
47. Miller L.R., Cano A. Comorbid chronic pain and depression: who is at risk?. J. Pain 2009, 10:619-627.
48. Mittal N., Joshi R., Hota D., Chakrabarti A. Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat. Phytother. Res. 2009, 23(4):507-512.
49. Moldofsky H. Rheumatic pain modulation syndrome: the interrelationships between sleep, central nervous system serotonin, and pain. Adv Neurol. 1982, 33:51-57.
50. Nagakura Y., Oe T., Aoki T., Matsuoka N. Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: a putative animal model of fibromyalgia. Pain 2009, 146:26-33.
51. Naranjo J.R., Arnedo A., Molinero M.T., Del Rio J. Involvement of spinal monoaminergic pathways in antinociception produced by substance P and neurotensin in rodents. Neuropharmacology 1989, 28:291-298.
52. Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 - inflammatory profile of pain syndromes. Med. Hypotheses 2007, 69:1169-1178.
53. Pall M.L. Nitric oxide synthase partial uncoupling as a key switching mechanism for the NO/ONOO-cycle. Med. Hypotheses 2007, 69:821-825.
54. Patel B.A., Arundell M., Parker K.H., Yeoman M.S., O'Hare D. Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci. 2005, 818:269-276.
55. Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266:730-732.
56. Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006, 27:24-31.
57. Russell I.J., Vaeroy H., Javors M., Nyberg F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum. 1992, 35:550-556.
58. Ruster M., Franke S., Spath M., Pongratz D.E., Stein G., Hein G.E. Detection of elevated N epsilon-carboxymethyllysine levels in muscular tissue and in serum of patients with fibromyalgia. Scand. J. Rheumatol. 2005, 34:460-463.
59. Sarandol A., Sarandol E., Eker S.S., Erdinc S., Vatansever E., Kirli S. Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum. Psychopharmacol. 2007, 22:67-73.
60. Sartorius N., Ustun T.B., Costa e Silva J.A., Goldberg D., Lecrubier Y., Ormel J., Von Korff M., Wittchen H.U. An international study of psychological problems in primary care. Preliminary report from the World Health Organization Collaborative Project on 'Psychological Problems in General Health Care'. Arch. Gen. Psychiatry 1993, 50:284-819.
61. Schwarz M.J., Spath M., Muller-Bardorff H., Pongratz D.E., Bondy B., Ackenheil M. Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients. Neurosci. Lett. 1999, 259:196-198.
62. Sharma S., Kulkarni S.K., Agrewala J.N., Chopra K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur. J. Pharmacol. 2006, 536:256-261.
63. Stahl S.M. Does depression hurt?. J. Clin. Psychiatry 2002, 63:273-274.
64. Staud R., Spaeth M. Psychophysical and neurochemical abnormalities of pain processing in fibromyalgia. CNS Spectr. 2008, 13:12-17.
65. Szelenyi J., Kiss J.P., Puskas E., Szelenyi M., Vizi E.S. Contribution of differently localized alpha 2- and beta-adrenoceptors in the modulation of TNF-alpha and IL-10 production in endotoxemic mice. Ann. N. Y. Acad. Sci. 2000, 917:145-153.
66. Uceyler N., Eberle T., Rolke R., Birklein F., Sommer C. Differential expression patterns of cytokines in complex regional pain syndrome. Pain 2007, 132:195-205.
67. Unnikrishnan M.K., Rao M.N. Curcumin inhibits nitrogen dioxide induced oxidation of hemoglobin. Mol. Cell Biochem. 1995, 146:35-37.
68. Wallace D.J. Is there a role for cytokine based therapies in fibromyalgia. Curr. Pharm. Des. 2006, 12:17-22.
69. Wills E.D. Mechanisms of lipid peroxide formation in tissues. Role of metals and haematin proteins in the catalysis of the oxidation unsaturated fatty acids. Biochim. Biophys. Acta 1965, 98:238-251.
70. Wu J., Fang L., Lin Q., Willis W.D. Nitric oxide synthase in spinal cord central sensitization following intradermal injection of capsaicin. Pain 2001, 94:47-58.
71. Xu Y., Ku B.S., Yao H.Y., Lin Y.H., Ma X., Zhang Y.H., Li X.J. The effects of curcumin on depressive-like behaviors in mice. Eur. J. Pharmacol. 2005, 518:40-46.
72. Yanik M., Erel O., Kati M. The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatr. 2004, 16:200-203.
73. Zeng Q., Wang S., Lim G., Yang L., Mao J., Sung B., Chang Y., Lim J.A., Guo G. Exacerbated mechanical allodynia in rats with depression-like behavior. Brain Res. 2008, 1200:27-38.