Involvement of calpain in hypoxia-induced damage in rat retina in vitro

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 131, Issue 2, 2002, Pages 221-225

  Tamada, Yoshiyuki ^a   Fukiage, Chiho ^a,b   Daibo, Sayaka ^a   Yoshida, Yukuo ^a   Azuma, Mitsuyoshi ^a,b   Shearer, Thomas R ^b  

^a SENJU PHARMACEUTICAL CO LTD   (Japan)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Calpain inhibitor SJA6017; Cell damage; Hypoxia; m Calpain; Rat; Retina; Spectrin; Calpain

Indexed keywords

CALPAIN; CALPASTATIN; CARBON DIOXIDE; CASEIN; FODRIN; GLUCOSE; LACTATE DEHYDROGENASE; N (4 FLUOROPHENYLSULFONYL)VALYLLEUCINAL; NITROGEN; OXYGEN; SJA 6017; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPOXIA; IMMUNOBLOTTING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RETINA GANGLION CELL; ZYMOGRAPHY;

EID: 0036161807     PISSN: 10964959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-4959(01)00489-4     Document Type: Article

References (29)

1. Activation of calpain in lens: A review and proposed mechanism
2. Identification and characterization of a retina-specific calpain (Rt88) from rat
3. Calcium-activated neutral protease (Calpain) system: Structure, function, and regulation
4. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: Implications for calpain regulation and evolution
5. Effect of calpain on the composition and structure of postsynaptic densities
6. Isolation and sequence analysis of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease
7. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
8. Postischemic reperfusion induces α-fodrin proteolysis by m-calpain in the synaptosome and nucleus in rat brain
9. N-Methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture
10. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
11. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
12. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract
13. Ischemic cell death in brain neurons
14. Cloning and expression of mRNA for calpain Lp82 from rat lens: Splice variant of p94
15. Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82
16. Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene
17. Oxidation enhances calpain-induced turbidity in young rat lenses
18. Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
19. Casein zymography: A method of study μ-calpain, m-calpain, and their inhibitory agents
20. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat
21. Spatial resolution of fodrin proteolysis in postischemic brain
22. Selective neuronal cell death induced by activation of m-calpain under conditions of ischemia/reperfusion
23. Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina
24. Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle
25. A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain
26. Structure and physiological function of calpains
27. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
28. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective
29. Three distinct phases of fodrin proteolysis induced in postischemic hippocampus