메뉴 건너뛰기




Volumn 1037, Issue 1-2, 2005, Pages 59-69

Calpain inhibitor MDL 28170 protects hypoxic-ischemic brain injury in neonatal rats by inhibition of both apoptosis and necrosis

Author keywords

Calpain; Caspase 3; Excitotoxicity; Immature brain; Neuronal cell death

Indexed keywords

ARACHIS OIL; CALPAIN; CASPASE 3; CYSTEINE PROTEINASE INHIBITOR; FODRIN; PROTEIN SUBUNIT; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER;

EID: 14944383996     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.12.050     Document Type: Article
Times cited : (68)

References (63)
  • 1
    • 0025985357 scopus 로고
    • Improved posthypoxic recovery with a membrane-permeable calpain inhibitor
    • L. Arlinghaus, S. Mehdi, and K.S. Lee Improved posthypoxic recovery with a membrane-permeable calpain inhibitor Eur. J. Pharmacol. 209 1991 123 125
    • (1991) Eur. J. Pharmacol. , vol.209 , pp. 123-125
    • Arlinghaus, L.1    Mehdi, S.2    Lee, K.S.3
  • 4
    • 0029100373 scopus 로고
    • Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices
    • E. Bednarski, P. Vanderklish, C. Gall, T.C. Saido, B.A. Bahr, and G. Lynch Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices Brain Res. 694 1995 147 157
    • (1995) Brain Res. , vol.694 , pp. 147-157
    • Bednarski, E.1    Vanderklish, P.2    Gall, C.3    Saido, T.C.4    Bahr, B.A.5    Lynch, G.6
  • 5
    • 0028941909 scopus 로고
    • Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: Evidence for apoptosis during selective neuronal loss
    • E.J. Beilharz, C.E. Williams, M. Dragunow, E.S. Sirimanne, and P.D. Gluckman Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss Brain Res. Mol. Brain Res. 29 1995 1 14
    • (1995) Brain Res. Mol. Brain Res. , vol.29 , pp. 1-14
    • Beilharz, E.J.1    Williams, C.E.2    Dragunow, M.3    Sirimanne, E.S.4    Gluckman, P.D.5
  • 6
    • 0024811768 scopus 로고
    • Developmental changes of calpain and calpastatin in rabbit brain
    • K. Blomgren, and J.O. Karlsson Developmental changes of calpain and calpastatin in rabbit brain Neurochem. Res. 14 1989 1149 1152
    • (1989) Neurochem. Res. , vol.14 , pp. 1149-1152
    • Blomgren, K.1    Karlsson, J.O.2
  • 7
    • 0029004414 scopus 로고
    • Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia
    • K. Blomgren, S. Kawashima, T.C. Saido, J.O. Karlsson, A. Elmered, and H. Hagberg Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia Brain Res. 684 1995 143 149
    • (1995) Brain Res. , vol.684 , pp. 143-149
    • Blomgren, K.1    Kawashima, S.2    Saido, T.C.3    Karlsson, J.O.4    Elmered, A.5    Hagberg, H.6
  • 8
    • 0035971091 scopus 로고    scopus 로고
    • Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: A mechanism of "pathological apoptosis"?
    • K. Blomgren, C. Zhu, X. Wang, J.O. Karlsson, A.L. Leverin, B.A. Bahr, C. Mallard, and H. Hagberg Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"? J. Biol. Chem. 276 2001 10191 10198
    • (2001) J. Biol. Chem. , vol.276 , pp. 10191-10198
    • Blomgren, K.1    Zhu, C.2    Wang, X.3    Karlsson, J.O.4    Leverin, A.L.5    Bahr, B.A.6    Mallard, C.7    Hagberg, H.8
  • 9
    • 0029015969 scopus 로고
    • Delayed antagonism of calpain reduces excitotoxicity in cultured neurons
    • J.R. Brorson, C.J. Marcuccilli, and R.J. Miller Delayed antagonism of calpain reduces excitotoxicity in cultured neurons Stroke 26 1995 1259 1266 (discussion 1267)
    • (1995) Stroke , vol.26 , pp. 1259-1266
    • Brorson, J.R.1    Marcuccilli, C.J.2    Miller, R.J.3
  • 10
    • 0027410425 scopus 로고
    • Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor
    • H. Caner, J.L. Collins, S.M. Harris, N.F. Kassell, and K.S. Lee Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor Brain Res. 607 1993 354 356
    • (1993) Brain Res. , vol.607 , pp. 354-356
    • Caner, H.1    Collins, J.L.2    Harris, S.M.3    Kassell, N.F.4    Lee, K.S.5
  • 11
    • 0033213973 scopus 로고    scopus 로고
    • Caspase and calpain substrates: Roles in synaptic plasticity and cell death
    • S.L. Chan, and M.P. Mattson Caspase and calpain substrates: roles in synaptic plasticity and cell death J. Neurosci. Res. 58 1999 167 190
    • (1999) J. Neurosci. Res. , vol.58 , pp. 167-190
    • Chan, S.L.1    Mattson, M.P.2
  • 14
    • 0025831476 scopus 로고
    • Calcium-activated neutral protease (calpain) system: Structure, function, and regulation
    • D.E. Croall, and G.N. DeMartino Calcium-activated neutral protease (calpain) system: structure, function, and regulation Physiol. Rev. 71 1991 813 847
    • (1991) Physiol. Rev. , vol.71 , pp. 813-847
    • Croall, D.E.1    Demartino, G.N.2
  • 15
    • 0031564831 scopus 로고    scopus 로고
    • Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain
    • C. de Torres, F. Munell, I. Ferrer, J. Reventos, and A. Macaya Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain Neurosci. Lett. 230 1997 1 4
    • (1997) Neurosci. Lett. , vol.230 , pp. 1-4
    • De Torres, C.1    Munell, F.2    Ferrer, I.3    Reventos, J.4    MacAya, A.5
  • 16
    • 0027517655 scopus 로고
    • Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor
    • K. Hiramatsu, N.F. Kassell, and K.S. Lee Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor Stroke 24 1993 1725 1728
    • (1993) Stroke , vol.24 , pp. 1725-1728
    • Hiramatsu, K.1    Kassell, N.F.2    Lee, K.S.3
  • 17
    • 0028098014 scopus 로고
    • Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia
    • S.C. Hong, Y. Goto, G. Lanzino, S. Soleau, N.F. Kassell, and K.S. Lee Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia Stroke 25 1994 663 669
    • (1994) Stroke , vol.25 , pp. 663-669
    • Hong, S.C.1    Goto, Y.2    Lanzino, G.3    Soleau, S.4    Kassell, N.F.5    Lee, K.S.6
  • 18
    • 85030816596 scopus 로고    scopus 로고
    • Write to the Help Desk NCBI|NLM|NIH Department of Health and Human Services Privacy Statement|Freedom of Information Act|Disclaimer.
    • S.T. Hou, J.P. MacManus, Molecular mechanisms of cerebral ischemia-induced neuronal death, 93-148. Write to the Help Desk NCBI|NLM|NIH Department of Health and Human Services Privacy Statement|Freedom of Information Act|Disclaimer.
    • Molecular Mechanisms of Cerebral Ischemia-induced Neuronal Death , pp. 93-148
    • Hou, S.T.1    MacManus, J.P.2
  • 19
    • 0034896809 scopus 로고    scopus 로고
    • Prolonged suppression of brain nitric oxide synthase activity by 7-nitroindazole protects against cerebral hypoxic-ischemic injury in neonatal rat
    • A. Ishida, W.H. Trescher, M.S. Lange, and M.V. Johnston Prolonged suppression of brain nitric oxide synthase activity by 7-nitroindazole protects against cerebral hypoxic-ischemic injury in neonatal rat Brain Dev. 23 2001 349 354
    • (2001) Brain Dev. , vol.23 , pp. 349-354
    • Ishida, A.1    Trescher, W.H.2    Lange, M.S.3    Johnston, M.V.4
  • 20
    • 0034090253 scopus 로고    scopus 로고
    • Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves
    • Q. Jiang, and P.K. Stys Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves J. Neurochem. 74 2000 2101 2107
    • (2000) J. Neurochem. , vol.74 , pp. 2101-2107
    • Jiang, Q.1    Stys, P.K.2
  • 23
    • 0030884358 scopus 로고    scopus 로고
    • Apoptosis and protein expression after focal cerebral ischemia in rat
    • Y. Li, M. Chopp, C. Powers, and N. Jiang Apoptosis and protein expression after focal cerebral ischemia in rat Brain Res. 765 1997 301 312
    • (1997) Brain Res. , vol.765 , pp. 301-312
    • Li, Y.1    Chopp, M.2    Powers, C.3    Jiang, N.4
  • 24
    • 0030293567 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • A. Macaya Apoptosis in the nervous system Rev. Neurol. 24 1996 1356 1360
    • (1996) Rev. Neurol. , vol.24 , pp. 1356-1360
    • MacAya, A.1
  • 25
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis. An overview of cell death
    • G. Majno, and I. Joris Apoptosis, oncosis, and necrosis. An overview of cell death Am. J. Pathol. 146 1995 3 15
    • (1995) Am. J. Pathol. , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 27
    • 0025970794 scopus 로고
    • Cell-penetrating inhibitors of calpain
    • S. Mehdi Cell-penetrating inhibitors of calpain Trends Biochem. Sci. 16 1991 150 153
    • (1991) Trends Biochem. Sci. , vol.16 , pp. 150-153
    • Mehdi, S.1
  • 28
    • 0024230246 scopus 로고
    • Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain
    • S. Mehdi, M.R. Angelastro, J.S. Wiseman, and P. Bey Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain Biochem. Biophys. Res. Commun. 157 1988 1117 1123
    • (1988) Biochem. Biophys. Res. Commun. , vol.157 , pp. 1117-1123
    • Mehdi, S.1    Angelastro, M.R.2    Wiseman, J.S.3    Bey, P.4
  • 29
    • 0028114708 scopus 로고
    • Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult
    • H. Mehmet, X. Yue, M.V. Squier, A. Lorek, E. Cady, J. Penrice, C. Sarraf, M. Wylezinska, V. Kirkbride, and C. Cooper Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult Neurosci. Lett. 181 1994 121 125
    • (1994) Neurosci. Lett. , vol.181 , pp. 121-125
    • Mehmet, H.1    Yue, X.2    Squier, M.V.3    Lorek, A.4    Cady, E.5    Penrice, J.6    Sarraf, C.7    Wylezinska, M.8    Kirkbride, V.9    Cooper, C.10
  • 32
    • 0029854806 scopus 로고    scopus 로고
    • Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
    • R. Nath, K.J. Raser, D. Stafford, I. Hajimohammadreza, A. Posner, H. Allen, R.V. Talanian, P. Yuen, R.B. Gilbertsen, and K.K. Wang Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme- like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis Biochem. J. 319 Pt 3 1996 683 690
    • (1996) Biochem. J. , vol.319 , Issue.3 PART , pp. 683-690
    • Nath, R.1    Raser, K.J.2    Stafford, D.3    Hajimohammadreza, I.4    Posner, A.5    Allen, H.6    Talanian, R.V.7    Yuen, P.8    Gilbertsen, R.B.9    Wang, K.K.10
  • 34
    • 0035742794 scopus 로고    scopus 로고
    • Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death
    • F.J. Northington, D.M. Ferriero, and L.J. Martin Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death Dev. Neurosci. 23 2001 186 191
    • (2001) Dev. Neurosci. , vol.23 , pp. 186-191
    • Northington, F.J.1    Ferriero, D.M.2    Martin, L.J.3
  • 35
    • 0142184241 scopus 로고    scopus 로고
    • Calpain inhibitors protect against axonal degeneration in a model of anti-ganglioside antibody-mediated motor nerve terminal injury
    • G.M. O'Hanlon, P.D. Humphreys, R.S. Goldman, S.K. Halstead, R.W. Bullens, J.J. Plomp, Y. Ushkaryov, and H.J. Willison Calpain inhibitors protect against axonal degeneration in a model of anti-ganglioside antibody-mediated motor nerve terminal injury Brain 126 2003 2497 2509
    • (2003) Brain , vol.126 , pp. 2497-2509
    • O'Hanlon, G.M.1    Humphreys, P.D.2    Goldman, R.S.3    Halstead, S.K.4    Bullens, R.W.5    Plomp, J.J.6    Ushkaryov, Y.7    Willison, H.J.8
  • 36
    • 0027501890 scopus 로고
    • Upregulation of calpain activity in neonatal rat brain after hypoxic-ischemia
    • K. Ostwald, H. Hagberg, P. Andine, and J.O. Karlsson Upregulation of calpain activity in neonatal rat brain after hypoxic-ischemia Brain Res. 630 1993 289 294
    • (1993) Brain Res. , vol.630 , pp. 289-294
    • Ostwald, K.1    Hagberg, H.2    Andine, P.3    Karlsson, J.O.4
  • 37
    • 0027934386 scopus 로고
    • Subcellular distribution of calpain and calpastatin immunoreactivity and fodrin proteolysis in rabbit hippocampus after hypoxia and glucocorticoid treatment
    • K. Ostwald, M. Hayashi, M. Nakamura, and S. Kawashima Subcellular distribution of calpain and calpastatin immunoreactivity and fodrin proteolysis in rabbit hippocampus after hypoxia and glucocorticoid treatment J. Neurochem. 63 1994 1069 1076
    • (1994) J. Neurochem. , vol.63 , pp. 1069-1076
    • Ostwald, K.1    Hayashi, M.2    Nakamura, M.3    Kawashima, S.4
  • 38
    • 0032479912 scopus 로고    scopus 로고
    • Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury
    • B.R. Pike, X. Zhao, J.K. Newcomb, R.M. Posmantur, K.K. Wang, and R.L. Hayes Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury NeuroReport 9 1998 2437 2442
    • (1998) NeuroReport , vol.9 , pp. 2437-2442
    • Pike, B.R.1    Zhao, X.2    Newcomb, J.K.3    Posmantur, R.M.4    Wang, K.K.5    Hayes, R.L.6
  • 39
    • 0032101643 scopus 로고    scopus 로고
    • Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures
    • B.R. Pike, X. Zhao, J.K. Newcomb, K.K. Wang, R.M. Posmantur, and R.L. Hayes Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures J. Neurosci. Res. 52 1998 505 520
    • (1998) J. Neurosci. Res. , vol.52 , pp. 505-520
    • Pike, B.R.1    Zhao, X.2    Newcomb, J.K.3    Wang, K.K.4    Posmantur, R.M.5    Hayes, R.L.6
  • 40
    • 0031029859 scopus 로고    scopus 로고
    • Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
    • C. Portera-Cailliau, D.L. Price, and L.J. Martin Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum J. Comp. Neurol. 378 1997 70 87
    • (1997) J. Comp. Neurol. , vol.378 , pp. 70-87
    • Portera-Cailliau, C.1    Price, D.L.2    Martin, L.J.3
  • 42
    • 0038725886 scopus 로고    scopus 로고
    • Ischemic neuronal death in the rat hippocampus: The calpain-calpastatin- caspase hypothesis
    • A. Rami Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis Neurobiol. Dis. 13 2003 75 88
    • (2003) Neurobiol. Dis. , vol.13 , pp. 75-88
    • Rami, A.1
  • 43
    • 0030934037 scopus 로고    scopus 로고
    • Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity
    • A. Rami, D. Ferger, and J. Krieglstein Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity Neurosci. Res. 27 1997 93 97
    • (1997) Neurosci. Res. , vol.27 , pp. 93-97
    • Rami, A.1    Ferger, D.2    Krieglstein, J.3
  • 45
    • 0031807548 scopus 로고    scopus 로고
    • A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: Morphological changes indicative of apoptosis
    • S. Renolleau, D. Aggoun-Zouaoui, Y. Ben-Ari, and C. Charriaut-Marlangue A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: morphological changes indicative of apoptosis Stroke 29 1998 1454 1460 (discussion 1461)
    • (1998) Stroke , vol.29 , pp. 1454-1460
    • Renolleau, S.1    Aggoun-Zouaoui, D.2    Ben-Ari, Y.3    Charriaut-Marlangue, C.4
  • 46
    • 0019366919 scopus 로고
    • The influence of immaturity on hypoxic-ischemic brain damage in the rat
    • J.E.d. Rice, R.C. Vannucci, and J.B. Brierley The influence of immaturity on hypoxic-ischemic brain damage in the rat Ann. Neurol. 9 1981 131 141
    • (1981) Ann. Neurol. , vol.9 , pp. 131-141
    • Rice, J.E.D.1    Vannucci, R.C.2    Brierley, J.B.3
  • 47
    • 0028282502 scopus 로고
    • Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
    • J.M. Roberts-Lewis, M.J. Savage, V.R. Marcy, L.R. Pinsker, and R. Siman Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain J. Neurosci. 14 1994 3934 3944
    • (1994) J. Neurosci. , vol.14 , pp. 3934-3944
    • Roberts-Lewis, J.M.1    Savage, M.J.2    Marcy, V.R.3    Pinsker, L.R.4    Siman, R.5
  • 48
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • S.M. Rothman, and J.W. Olney Glutamate and the pathophysiology of hypoxic-ischemic brain damage Ann. Neurol. 19 1986 105 111
    • (1986) Ann. Neurol. , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 51
    • 0024347477 scopus 로고
    • Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus
    • P. Seubert, K. Lee, and G. Lynch Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus Brain Res. 492 1989 366 370
    • (1989) Brain Res. , vol.492 , pp. 366-370
    • Seubert, P.1    Lee, K.2    Lynch, G.3
  • 52
    • 0031051736 scopus 로고    scopus 로고
    • Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats
    • R.S. Sidhu, U.I. Tuor, and M.R. Del Bigio Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats Neurosci Lett. 223 1997 129 132
    • (1997) Neurosci Lett. , vol.223 , pp. 129-132
    • Sidhu, R.S.1    Tuor, U.I.2    Del Bigio, M.R.3
  • 53
    • 0024020782 scopus 로고
    • Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo
    • R. Siman, and J.C. Noszek Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo Neuron 1 1988 279 287
    • (1988) Neuron , vol.1 , pp. 279-287
    • Siman, R.1    Noszek, J.C.2
  • 54
    • 0031452173 scopus 로고    scopus 로고
    • Structure and physiological function of calpains
    • H. Sorimachi, S. Ishiura, and K. Suzuki Structure and physiological function of calpains Biochem. J. 328 Pt. 3 1997 721 732
    • (1997) Biochem. J. , vol.328 , Issue.3 PART , pp. 721-732
    • Sorimachi, H.1    Ishiura, S.2    Suzuki, K.3
  • 56
    • 0029121617 scopus 로고
    • Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: A light microscopic study
    • J. Towfighi, N. Zec, J. Yager, C. Housman, and R.C. Vannucci Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study Acta Neuropathol. (Berl.) 90 1995 375 386
    • (1995) Acta Neuropathol. (Berl.) , vol.90 , pp. 375-386
    • Towfighi, J.1    Zec, N.2    Yager, J.3    Housman, C.4    Vannucci, R.C.5
  • 57
    • 0030862806 scopus 로고    scopus 로고
    • Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury
    • W.H. Trescher, S. Ishiwa, and M.V. Johnston Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury Brain Dev. 19 1997 326 338
    • (1997) Brain Dev. , vol.19 , pp. 326-338
    • Trescher, W.H.1    Ishiwa, S.2    Johnston, M.V.3
  • 58
    • 14944355121 scopus 로고    scopus 로고
    • Cell death mode switch from necrosis to apoptosis in brain
    • H. Ueda, and R. Fujita Cell death mode switch from necrosis to apoptosis in brain Biol. Pharm. Bull. 27 2004 950 955
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 950-955
    • Ueda, H.1    Fujita, R.2
  • 59
    • 0033956278 scopus 로고    scopus 로고
    • Calpain and caspase: Can you tell the difference?
    • K.K. Wang Calpain and caspase: can you tell the difference? Trends Neurosci. 23 2000 20 26
    • (2000) Trends Neurosci. , vol.23 , pp. 20-26
    • Wang, K.K.1
  • 61
    • 3042717151 scopus 로고    scopus 로고
    • Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats
    • N. Yasuoka, W. Nakajima, A. Ishida, and G. Takada Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats Brain Res. Dev. Brain Res. 151 2004 129 139
    • (2004) Brain Res. Dev. Brain Res. , vol.151 , pp. 129-139
    • Yasuoka, N.1    Nakajima, W.2    Ishida, A.3    Takada, G.4
  • 63
    • 0031690836 scopus 로고    scopus 로고
    • Calpain inhibitors: Novel neuroprotectants and potential anticataract agents
    • P. Yuen, and K.K. Wang Calpain inhibitors: novel neuroprotectants and potential anticataract agents Drugs Future 23 1998 741 749
    • (1998) Drugs Future , vol.23 , pp. 741-749
    • Yuen, P.1    Wang, K.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.